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Recent advance of peptide-based molecules and nonpeptidic small-molecules modulating PD-1/PD-L1 protein-protein interaction or targeting PD-L1 protein degradation

European journal of medicinal chemistry, 2021-03, Vol.213, p.113170, Article 113170

2021

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Small Molecule Agents Targeting PD-1 Checkpoint Pathway for Cancer Immunotherapy: Mechanisms of Action and Other Considerations for Their Advanced Development

Frontiers in immunology, 2022-05, Vol.13, p.752065-752065

2022

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Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1

European journal of medicinal chemistry, 2020-08, Vol.199, p.112377, Article 112377

2020

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Design, synthesis, and optimization of novel PD-L1 inhibitors and the identification of a highly potent and orally bioavailable PD-L1 inhibitor

European journal of medicinal chemistry, 2024-11, Vol.277, p.116730, Article 116730

2024

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Synergistic enhancement of immunological responses triggered by hyperthermia sensitive Pt NPs via NIR laser to inhibit cancer relapse and metastasis

Bioactive materials, 2022-01, Vol.7, p.389-400

2022

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Synthesis and pharmacological evaluation of novel resorcinol biphenyl ether analogs as small molecule inhibitors of PD-1/PD-L1 with benign toxicity profiles for cancer treatment

Biochemical pharmacology, 2021-06, Vol.188, p.114522, Article 114522

2021

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Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Molecules (Basel, Switzerland), 2021-06, Vol.26 (11), p.3347

2021

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Molecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors

Bioorganic & medicinal chemistry, 2022-01, Vol.54, p.116579-116579, Article 116579

2022

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Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway

Acta pharmacologica Sinica, 2021-01, Vol.42 (1), p.1-9

2021

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Development of the Inhibitors that Target the PD-1/PD-L1 Interaction-A Brief Look at Progress on Small Molecules, Peptides and Macrocycles

Molecules (Basel, Switzerland), 2019-05, Vol.24 (11), p.2071

2019

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Immunomodulators targeting the PD‐1/PD‐L1 protein‐protein interaction: From antibodies to small molecules

Medicinal research reviews, 2019-01, Vol.39 (1), p.265-301

2019

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CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?

Molecules (Basel, Switzerland), 2019-08, Vol.24 (15), p.2804

2019

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Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction

European journal of medicinal chemistry, 2021-11, Vol.223, p.113637-113637, Article 113637

2021

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A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy

Frontiers in immunology, 2021-05, Vol.12, p.654463-654463

2021

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Advance investigation on synthetic small-molecule inhibitors targeting PD-1/PD-L1 signaling pathway

Life sciences (1973), 2021-10, Vol.282, p.119813-119813, Article 119813

2021

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Development of small-molecule immune checkpoint inhibitors of PD-1/PD-L1 as a new therapeutic strategy for tumour immunotherapy

Journal of drug targeting, 2019-03, Vol.27 (3), p.244-256

2019

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Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

Oncotarget, 2017-09, Vol.8 (42), p.72167-72181

2017

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Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules

European journal of medicinal chemistry, 2020-01, Vol.186, p.111876-111876, Article 111876

2020

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Identification of the FDA‐Approved Drug Pyrvinium as a Small‐Molecule Inhibitor of the PD‐1/PD‐L1 Interaction

ChemMedChem, 2021-09, Vol.16 (18), p.2769-2774

2021

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Novel therapies emerging in oncology to target the TGF-β pathway

Journal of hematology and oncology, 2021-04, Vol.14 (1), p.55-55, Article 55

2021

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Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review

Cancer cell international, 2021-04, Vol.21 (1), p.239-239, Article 239

2021

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Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

Cancer cell, 2019-11, Vol.36 (5), p.483-497.e15

2019

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Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?

European journal of medicinal chemistry, 2019-01, Vol.161, p.378-398

2019

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Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

Structure (London), 2017-08, Vol.25 (8), p.1163-1174

2017

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Molecular Mechanism of Small-Molecule Inhibitors in Blocking the PD-1/PD-L1 Pathway through PD-L1 Dimerization

International journal of molecular sciences, 2021-04, Vol.22 (9), p.4766

2021

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Recent advance of peptide-based molecules and nonpeptidic small-molecules modulating PD-1/PD-L1 protein-protein interaction or targeting PD-L1 protein degradation

Small Molecule Agents Targeting PD-1 Checkpoint Pathway for Cancer Immunotherapy: Mechanisms of Action and Other Considerations for Their Advanced Development

Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1

Design, synthesis, and optimization of novel PD-L1 inhibitors and the identification of a highly potent and orally bioavailable PD-L1 inhibitor

Synergistic enhancement of immunological responses triggered by hyperthermia sensitive Pt NPs via NIR laser to inhibit cancer relapse and metastasis

Synthesis and pharmacological evaluation of novel resorcinol biphenyl ether analogs as small molecule inhibitors of PD-1/PD-L1 with benign toxicity profiles for cancer treatment

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Molecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors

Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway

Development of the Inhibitors that Target the PD-1/PD-L1 Interaction-A Brief Look at Progress on Small Molecules, Peptides and Macrocycles

Immunomodulators targeting the PD‐1/PD‐L1 protein‐protein interaction: From antibodies to small molecules

CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?

Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction

A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy

Advance investigation on synthetic small-molecule inhibitors targeting PD-1/PD-L1 signaling pathway

Development of small-molecule immune checkpoint inhibitors of PD-1/PD-L1 as a new therapeutic strategy for tumour immunotherapy

Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules

Identification of the FDA‐Approved Drug Pyrvinium as a Small‐Molecule Inhibitor of the PD‐1/PD‐L1 Interaction

Novel therapies emerging in oncology to target the TGF-β pathway

Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review

Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?

Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

Molecular Mechanism of Small-Molecule Inhibitors in Blocking the PD-1/PD-L1 Pathway through PD-L1 Dimerization

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