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In Vitro and In Silico Characterization of Lemborexant (E2006), a Novel Dual Orexin Receptor Antagonist

The Journal of pharmacology and experimental therapeutics, 2017-08, Vol.362 (2), p.287-295

2017

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Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

Nature communications, 2021-02, Vol.12 (1), p.815-11, Article 815

2021

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Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5119-5138

2020

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Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA

Structure (London), 2018-01, Vol.26 (1), p.7-19.e5

2018

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Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.11045-11053

2020

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Orexin-A attenuated motion sickness through modulating neural activity in hypothalamus nuclei

British journal of pharmacology, 2024-05, Vol.181 (9), p.1474-1493

2024

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Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (3), p.126893-126893, Article 126893

2020

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Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure–Activity Relationships, and Sleep‐Promoting Properties in Rats

ChemMedChem, 2019-07, Vol.14 (13), p.1257-1270

2019

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Sleep modulates haematopoiesis and protects against atherosclerosis

Nature (London), 2019-02, Vol.566 (7744), p.383-387

2019

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Possible neuronal mechanisms of sleep disturbances in patients with autism spectrum disorders and attention deficit hyperactivity disorder

Medical hypotheses, 2016-12, Vol.97, p.131-133

Kohyama, Jun

2016

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

Cell metabolism, 2013-09, Vol.18 (3), p.416-430

2013

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A genetically encoded sensor for in vivo imaging of orexin neuropeptides

Nature methods, 2022-02, Vol.19 (2), p.231

2022

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Orexin prevents depressive-like behavior by promoting stress resilience

Molecular psychiatry, 2019-02, Vol.24 (2), p.282-293

2019

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Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Nature (London), 2015-03, Vol.519 (7542), p.247-250

2015

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Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates

Scientific reports, 2024-04, Vol.14 (1), p.7690-7690, Article 7690

2024

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Structure-based development of a subtype-selective orexin 1 receptor antagonist

Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (30), p.18059-18067

2020

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Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice

Nature communications, 2021-10, Vol.12 (1), p.6137-6137, Article 6137

2021

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Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks

Nature communications, 2016-04, Vol.7 (1), p.11395-11395, Article 11395

2016

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Activation of orexin system facilitates anesthesia emergence and pain control

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (45), p.E10740-E10747

2018

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Orexin modulates behavioral fear expression through the locus coeruleus

Nature communications, 2017-11, Vol.8 (1), p.1606-14, Article 1606

2017

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Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

Nature communications, 2021-09, Vol.12 (1), p.5249-5249, Article 5249

2021

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Orexin receptor antagonists in the pathophysiology and treatment of sleep disorders and epilepsy

Neuropeptides (Edinburgh), 2023-06, Vol.99, p.102335-102335, Article 102335

2023

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Orexin/hypocretin role in reward: implications for opioid and other addictions

British journal of pharmacology, 2015-01, Vol.172 (2), p.334-348

2015

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Investigating the role of the amygdala orexin receptor 1 in memory acquisition and extinction in a rat model of PTSD

Behavioural brain research, 2020-04, Vol.384, p.112455-112455, Article 112455

2020

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The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion

Genetics (Austin), 2016-11, Vol.204 (3), p.1151-1159

2016

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In Vitro and In Silico Characterization of Lemborexant (E2006), a Novel Dual Orexin Receptor Antagonist

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity

Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA

Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor

Orexin-A attenuated motion sickness through modulating neural activity in hypothalamus nuclei

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group

Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure–Activity Relationships, and Sleep‐Promoting Properties in Rats

Sleep modulates haematopoiesis and protects against atherosclerosis

Possible neuronal mechanisms of sleep disturbances in patients with autism spectrum disorders and attention deficit hyperactivity disorder

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

A genetically encoded sensor for in vivo imaging of orexin neuropeptides

Orexin prevents depressive-like behavior by promoting stress resilience

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates

Structure-based development of a subtype-selective orexin 1 receptor antagonist

Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice

Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks

Activation of orexin system facilitates anesthesia emergence and pain control

Orexin modulates behavioral fear expression through the locus coeruleus

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

Orexin receptor antagonists in the pathophysiology and treatment of sleep disorders and epilepsy

Orexin/hypocretin role in reward: implications for opioid and other addictions

Investigating the role of the amygdala orexin receptor 1 in memory acquisition and extinction in a rat model of PTSD

The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion

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