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Monoamine transporters: structure, intrinsic dynamics and allosteric regulation

Nature structural & molecular biology, 2019-07, Vol.26 (7), p.545

2019

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α-PPP and its derivatives are selective partial releasers at the human norepinephrine transporter: A pharmacological characterization of interactions between pyrrolidinopropiophenones and high and low affinity monoamine transporters

Neuropharmacology, 2021-06, Vol.190, p.108570

2021

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Substituted methcathinones differ in transporter and receptor interactions

Biochemical pharmacology, 2013-06, Vol.85 (12), p.1803-1815

2013

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LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake

Science (American Association for the Advancement of Science), 2007-09, Vol.317 (5843), p.1390-1393

2007

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Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET

Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (38), p.15810-15815

2011

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What Contributes to Serotonin–Norepinephrine Reuptake Inhibitors’ Dual-Targeting Mechanism? The Key Role of Transmembrane Domain 6 in Human Serotonin and Norepinephrine Transporters Revealed by Molecular Dynamics Simulation

ACS chemical neuroscience, 2018-05, Vol.9 (5), p.1128-1140

2018

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Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

The Journal of biological chemistry, 2012-12, Vol.287 (52), p.43694-43707

2012

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Dopamine and serotonin signaling during two sensitive developmental periods differentially impact adult aggressive and affective behaviors in mice

Molecular psychiatry, 2014-06, Vol.19 (6), p.688-698

2014

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How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers

Biochemical Society transactions, 2019-06, Vol.47 (3), p.861-874

2019

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Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters

Psychopharmacology, 2019-03, Vol.236 (3), p.939-952

2019

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Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)

Neuropharmacology, 2014-12, Vol.87, p.206-213

2014

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Opioid‐induced inhibition of the human 5‐HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome

British journal of pharmacology, 2018-02, Vol.175 (3), p.532-543

2018

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The Designer Methcathinone Analogs, Mephedrone and Methylone, are Substrates for Monoamine Transporters in Brain Tissue

Neuropsychopharmacology (New York, N.Y.), 2012-04, Vol.37 (5), p.1192-1203

2012

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Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2‑[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.1000-1013

2014

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Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models

Nature communications, 2022-11, Vol.13 (1), p.7032-17, Article 7032

2022

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Disturbed neurotransmitter homeostasis in ether lipid deficiency

Human molecular genetics, 2019-06, Vol.28 (12), p.2046-2061

2019

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Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD

Molecular psychiatry, 2018-09, Vol.23 (9), p.1929-1936

2018

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Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function

PloS one, 2022-09, Vol.17 (9), p.e0275182

2022

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Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue

PLoS biology, 2019-01, Vol.17 (1), p.e2006571-e2006571

2019

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Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (29), p.12137-12142

2011

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Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro

The Journal of pharmacology and experimental therapeutics, 2006-11, Vol.319 (2), p.561

2006

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The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats

Psychopharmacology, 2020-12, Vol.237 (12), p.3703-3714

2020

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Regulation of monoamine transporters: Role of transporter phosphorylation

Pharmacology & therapeutics (Oxford), 2011-02, Vol.129 (2), p.220-238

2011

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Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters

The Journal of pharmacology and experimental therapeutics, 2016-10, Vol.359 (1), p.159

2016

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Using a collection of MUPP1 domains to investigate the similarities of neurotransmitter transporters C-terminal PDZ motifs

Biochemical and biophysical research communications, 2014-11, Vol.454 (1), p.25-29

2014

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Monoamine transporters: structure, intrinsic dynamics and allosteric regulation

α-PPP and its derivatives are selective partial releasers at the human norepinephrine transporter: A pharmacological characterization of interactions between pyrrolidinopropiophenones and high and low affinity monoamine transporters

Substituted methcathinones differ in transporter and receptor interactions

LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake

Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET

What Contributes to Serotonin–Norepinephrine Reuptake Inhibitors’ Dual-Targeting Mechanism? The Key Role of Transmembrane Domain 6 in Human Serotonin and Norepinephrine Transporters Revealed by Molecular Dynamics Simulation

Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

Dopamine and serotonin signaling during two sensitive developmental periods differentially impact adult aggressive and affective behaviors in mice

How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers

Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters

Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)

Opioid‐induced inhibition of the human 5‐HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome

The Designer Methcathinone Analogs, Mephedrone and Methylone, are Substrates for Monoamine Transporters in Brain Tissue

Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2‑[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues

Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models

Disturbed neurotransmitter homeostasis in ether lipid deficiency

Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD

Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue

Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters

Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro

The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats

Regulation of monoamine transporters: Role of transporter phosphorylation

Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters

Using a collection of MUPP1 domains to investigate the similarities of neurotransmitter transporters C-terminal PDZ motifs

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