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Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis

The Journal of immunology (1950), 2017-09, Vol.199 (5), p.1543-1552

Suvas, Susmit

2017

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Selective G protein signaling driven by substance P-neurokinin receptor dynamics

Nature chemical biology, 2022-01, Vol.18 (1), p.109

2022

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Substance P and pain chronicity

Cell and tissue research, 2019-01, Vol.375 (1), p.227-241

Zieglgänsberger, W.

2019

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The neurokinin-1 receptor is involved in the mediation of endotoxin-induced fever in mice

Neuropeptides (Edinburgh), 2017-10, Vol.65, p.148-149

2017

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A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Nature nanotechnology, 2019-12, Vol.14 (12), p.1150-1159

2019

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Targeting the neurokinin-1 receptor inhibits growth of human pancreatic cancer cells

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2021-07, Vol.21, p.S75-S76

2021

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Substance P activates Mas-related G protein–coupled receptors to induce itch

Journal of allergy and clinical immunology, 2017-08, Vol.140 (2), p.447-453.e3

2017

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SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors

Proceedings of the National Academy of Sciences - PNAS, 2017-05, Vol.114 (20), p.E4002-E4009

2017

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Evaluation of Efficacy of Adding Aprepitant to Palonosetron and Dexamethasone in Carboplatin and Etoposide Therapy

Biological and Pharmaceutical Bulletin, 2024/06/19, Vol.47(6), pp.1189-1195

2024

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Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

Nature communications, 2019-01, Vol.10 (1), p.17-11, Article 17

2019

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PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk

Cancer research (Chicago, Ill.), 2017-04, Vol.77 (8), p.1868-1879

2017

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Clinical presentation, management, and pathophysiology of neuropathic itch

Lancet neurology, 2018-08, Vol.17 (8), p.709-720

2018

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Comment on "Dexamethasone-sparing on days 2-4 with combined palonosteron, neurokinin-1 receptor antagonist, and olanzapine in cisplatin: a randomized phase III trial (SPARED Trial)"

British journal of cancer, 2024-04, Vol.130 (6), p.895-896

2024

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Illuminating the structural basis of human neurokinin 1 receptor (NK1R) antagonism through classical all-atoms molecular dynamics simulations

Journal of cellular biochemistry, 2023-11, Vol.124 (11), p.1848-1869

2023

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Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

Nature communications, 2019-02, Vol.10 (1), p.638-638, Article 638

2019

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Chronic itch: emerging treatments following new research concepts

British journal of pharmacology, 2021-12, Vol.178 (24), p.4775-4791

2021

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Characterisation of lamina I anterolateral system neurons that express Cre in a Phox2a-Cre mouse line

Scientific reports, 2021-09, Vol.11 (1), p.17912-17912, Article 17912

2021

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A phase 3 safety study of fosnetupitant as an antiemetic in patients receiving anthracycline and cyclophosphamide: CONSOLE‐BC

Cancer, 2022-04, Vol.128 (8), p.1692-1698

2022

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Neuronal Activities in the Rostral Ventromedial Medulla Associated with Experimental Occlusal Interference-Induced Orofacial Hyperalgesia

The Journal of neuroscience, 2022-07, Vol.42 (27), p.5314-5329

2022

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Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief

Proceedings of the National Academy of Sciences - PNAS, 2023-05, Vol.120 (22), p.e2220979120-e2220979120

2023

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Comparing the Efficacy of Fosnetupitant, an NK1 Receptor Antagonist in CDDP-Based Regimens, with That of Fosaprepitant and Aprepitant: A Retrospective Observational Study

Biological and Pharmaceutical Bulletin, 2024/03/25, Vol.47(3), pp.692-697

2024

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A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFNγ

Scientific reports, 2017-08, Vol.7 (1), p.9417-19, Article 9417

2017

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Pain Inhibits GRPR Neurons via GABAergic Signaling in the Spinal Cord

Scientific reports, 2019-11, Vol.9 (1), p.15804-11, Article 15804

2019

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Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis

Selective G protein signaling driven by substance P-neurokinin receptor dynamics

Substance P and pain chronicity

The neurokinin-1 receptor is involved in the mediation of endotoxin-induced fever in mice

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Targeting the neurokinin-1 receptor inhibits growth of human pancreatic cancer cells

Substance P activates Mas-related G protein–coupled receptors to induce itch

SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors

Evaluation of Efficacy of Adding Aprepitant to Palonosetron and Dexamethasone in Carboplatin and Etoposide Therapy

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk

Clinical presentation, management, and pathophysiology of neuropathic itch

Comment on "Dexamethasone-sparing on days 2-4 with combined palonosteron, neurokinin-1 receptor antagonist, and olanzapine in cisplatin: a randomized phase III trial (SPARED Trial)"

Illuminating the structural basis of human neurokinin 1 receptor (NK1R) antagonism through classical all-atoms molecular dynamics simulations

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

Chronic itch: emerging treatments following new research concepts

Characterisation of lamina I anterolateral system neurons that express Cre in a Phox2a-Cre mouse line

A phase 3 safety study of fosnetupitant as an antiemetic in patients receiving anthracycline and cyclophosphamide: CONSOLE‐BC

Neuronal Activities in the Rostral Ventromedial Medulla Associated with Experimental Occlusal Interference-Induced Orofacial Hyperalgesia

Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief

Comparing the Efficacy of Fosnetupitant, an NK1 Receptor Antagonist in CDDP-Based Regimens, with That of Fosaprepitant and Aprepitant: A Retrospective Observational Study

A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFNγ

Dexamethasone-sparing on days 2-4 with combined palonosetron, neurokinin-1 receptor antagonist, and olanzapine in cisplatin: a randomized phase III trial (SPARED Trial)

Integrated safety profile of selinexor in multiple myeloma: experience from 437 patients enrolled in clinical trials

Pain Inhibits GRPR Neurons via GABAergic Signaling in the Spinal Cord

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