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Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide

British journal of anaesthesia : BJA, 2014-12, Vol.113 (6), p.935-944

2014

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A review of morphine and morphine-6-glucuronide’s pharmacokinetic–pharmacodynamic relationships in experimental and clinical pain

European journal of pharmaceutical sciences, 2015-07, Vol.74, p.45-62

2015

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Pharmacokinetic and neuroimmune pharmacogenetic impacts on slow-release morphine cancer pain control and adverse effects

The pharmacogenomics journal, 2024-06, Vol.24 (3), p.18

2024

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Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats

Vaccine, 2012-06, Vol.30 (31), p.4617-4624

2012

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Metabolism and pharmacokinetics of morphine in neonates: A review

Clinics (São Paulo, Brazil), 2016-08, Vol.71 (8), p.474-480

Pacifici, Gian Maria

2016

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Predictive Performance of a Recently Developed Population Pharmacokinetic Model for Morphine and its Metabolites in New Datasets of (Preterm) Neonates, Infants and Children

Clinical pharmacokinetics, 2011, Vol.50 (1), p.51-63

2011

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No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients

Basic & clinical pharmacology & toxicology, 2022-01, Vol.130 (1), p.93-102

2022

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Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication

The pharmacogenomics journal, 2007-08, Vol.7 (4), p.257-265

2007

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Relative contribution of morphine and morphine-6-glucuronide to the analgesic effect after morphine administration

British journal of anaesthesia : BJA, 2015-06, Vol.114 (6), p.1007-1007

2015

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Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo

Drug metabolism and disposition, 2016-07, Vol.44 (7), p.1123-1138

2016

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Morphine metabolism, transport and brain disposition

Metabolic brain disease, 2012-03, Vol.27 (1), p.1-5

2012

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Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.S132-S139

2017

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Time-dependent postmortem redistribution of morphine and its metabolites in blood and alternative matrices—application of CT-guided biopsy sampling

International journal of legal medicine, 2017-03, Vol.131 (2), p.379-389

2017

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Mice Lacking Multidrug Resistance Protein 3 Show Altered Morphine Pharmacokinetics and Morphine-6-Glucuronide Antinociception

Proceedings of the National Academy of Sciences - PNAS, 2005-05, Vol.102 (20), p.7274-7279

2005

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Post-mortem levels and tissue distribution of codeine, codeine-6-glucuronide, norcodeine, morphine and morphine glucuronides in a series of codeine-related deaths

Forensic science international, 2016-05, Vol.262, p.128-137

2016

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A Randomized, Crossover Study on the Effect of Food on the Pharmacokinetic Characteristics of Morphine ARER (MorphaBond™ ER), an Abuse-Deterrent Formulation of Extended-Release Morphine

Advances in therapy, 2019-09, Vol.36 (9), p.2394-2401

2019

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Morphine is not a prodrug

British journal of anaesthesia : BJA, 2015-06, Vol.114 (6), p.1005-1006

2015

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Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC–MS assay for delayed analyses of pharmacokinetic samples in rats

Journal of pharmaceutical and biomedical analysis, 2013-02, Vol.74, p.291-297

2013

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Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients

Clinical pharmacokinetics, 2016-06, Vol.55 (6), p.697-709

2016

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Postmortem redistribution of the heroin metabolites morphine and morphine-3-glucuronide in rabbits over 24 h

International journal of legal medicine, 2016-03, Vol.130 (2), p.519-531

2016

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Naloxone Reversal of Morphine- and Morphine-6-Glucuronide-induced Respiratory Depression in Healthy Volunteers: A Mechanism-based Pharmacokinetic-Pharmacodynamic Modeling Study

Anesthesiology (Philadelphia), 2010-06, Vol.112 (6), p.1417-1427

2010

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Pharmacokinetic modeling of subcutaneous heroin and its metabolites in blood and brain of mice

Addiction biology, 2013-01, Vol.18 (1), p.1-7

2013

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Disappearance of 6-acetylmorphine, morphine and codeine from human scalp hair after discontinuation of opiate abuse

Forensic science international, 2013-04, Vol.227 (1), p.64-68

2013

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Melanocortin-1 receptor gene variants affect pain and μ-opioid analgesia in mice and humans

Journal of medical genetics, 2005-07, Vol.42 (7), p.583-587

2005

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Morphine induces hyperalgesia without involvement of μ-opioid receptor or morphine-3-glucuronide

Molecular medicine (Cambridge, Mass.), 2012-12, Vol.18 (9), p.1320-1326

2012

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Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide

A review of morphine and morphine-6-glucuronide’s pharmacokinetic–pharmacodynamic relationships in experimental and clinical pain

Pharmacokinetic and neuroimmune pharmacogenetic impacts on slow-release morphine cancer pain control and adverse effects

Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats

Metabolism and pharmacokinetics of morphine in neonates: A review

Predictive Performance of a Recently Developed Population Pharmacokinetic Model for Morphine and its Metabolites in New Datasets of (Preterm) Neonates, Infants and Children

No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients

Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication

Relative contribution of morphine and morphine-6-glucuronide to the analgesic effect after morphine administration

Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo

Morphine metabolism, transport and brain disposition

Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite

Time-dependent postmortem redistribution of morphine and its metabolites in blood and alternative matrices—application of CT-guided biopsy sampling

Mice Lacking Multidrug Resistance Protein 3 Show Altered Morphine Pharmacokinetics and Morphine-6-Glucuronide Antinociception

Post-mortem levels and tissue distribution of codeine, codeine-6-glucuronide, norcodeine, morphine and morphine glucuronides in a series of codeine-related deaths

A Randomized, Crossover Study on the Effect of Food on the Pharmacokinetic Characteristics of Morphine ARER (MorphaBond™ ER), an Abuse-Deterrent Formulation of Extended-Release Morphine

Morphine is not a prodrug

Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC–MS assay for delayed analyses of pharmacokinetic samples in rats

Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients

Postmortem redistribution of the heroin metabolites morphine and morphine-3-glucuronide in rabbits over 24 h

Naloxone Reversal of Morphine- and Morphine-6-Glucuronide-induced Respiratory Depression in Healthy Volunteers: A Mechanism-based Pharmacokinetic-Pharmacodynamic Modeling Study

Pharmacokinetic modeling of subcutaneous heroin and its metabolites in blood and brain of mice

Disappearance of 6-acetylmorphine, morphine and codeine from human scalp hair after discontinuation of opiate abuse

Melanocortin-1 receptor gene variants affect pain and μ-opioid analgesia in mice and humans

Morphine induces hyperalgesia without involvement of μ-opioid receptor or morphine-3-glucuronide

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