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Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

Cell reports (Cambridge), 2021-08, Vol.36 (9), p.109648-109648, Article 109648

2021

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Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5

Molecular pharmacology, 2014-12, Vol.86 (6), p.774-785

2014

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An allosteric modulator to control endogenous G protein-coupled receptors with light

Nature chemical biology, 2014-10, Vol.10 (10), p.813-815

2014

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Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment

Neuropharmacology, 2017-03, Vol.115, p.73-91

2017

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Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery

Neuropharmacology, 2017-03, Vol.115, p.60-72

2017

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Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site

Biochemical pharmacology, 2020-07, Vol.177, p.114013, Article 114013

2020

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Structural insights into the activation of metabotropic glutamate receptors

Nature (London), 2019-02, Vol.566 (7742), p.79-84

2019

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Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)

The Journal of biological chemistry, 2014-10, Vol.289 (41), p.28460-28477

2014

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Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract

World journal of gastroenterology : WJG, 2017-07, Vol.23 (25), p.4500-4507

2017

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Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

Nature chemical biology, 2015-02, Vol.11 (2), p.134-140

2015

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Activation of type 5 metabotropic glutamate receptor promotes the proliferation of rat retinal progenitor cell via activation of the PI-3-K and MAPK signaling pathways

Neuroscience, 2016-05, Vol.322, p.138-151

2016

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Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to descending pain facilitation in healthy and arthritic animals

Neuroscience, 2016-01, Vol.312, p.108-119

2016

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Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis

Cell metabolism, 2019-11, Vol.30 (5), p.877

2019

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Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors

Acta pharmacologica Sinica, 2021-08, Vol.42 (8), p.1354-1367

2021

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Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

Current neuropharmacology, 2016-07, Vol.14 (5), p.441-454

2016

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Accumbens nNOS Interneurons Regulate Cocaine Relapse

The Journal of neuroscience, 2017-01, Vol.37 (4), p.742-756

2017

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Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation

Neuron (Cambridge, Mass.), 2019-10, Vol.104 (2), p.338-352.e7

2019

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Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease

Brain (London, England : 1878), 2016-02, Vol.139 (Pt 2), p.526-546

2016

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Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

PLoS pathogens, 2017-11, Vol.13 (11), p.e1006733

2017

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An antagonist-based two-photon fluorogenic probe for imaging metabotropic glutamate receptor 5 in neuronal cells

Talanta (Oxford), 2024-08, Vol.275, p.126167-126167, Article 126167

2024

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Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5

Nature communications, 2024-08, Vol.15 (1), p.7519-14, Article 7519

2024

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Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

Journal of neurochemistry, 2021-01, Vol.156 (2), p.225-248

2021

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Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer

Archives of biochemistry and biophysics, 2023-08, Vol.744, p.109698-109698, Article 109698

2023

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Inhibition of mGluR5 ameliorates lipid accumulation and inflammation in HepG2 cells

Biochemical and biophysical research communications, 2023-04, Vol.653, p.1-11

2023

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Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Bioorganic & medicinal chemistry letters, 2017-11, Vol.27 (21), p.4858-4866

2017

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Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5

An allosteric modulator to control endogenous G protein-coupled receptors with light

Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery

Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site

Structural insights into the activation of metabotropic glutamate receptors

Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)

Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

Activation of type 5 metabotropic glutamate receptor promotes the proliferation of rat retinal progenitor cell via activation of the PI-3-K and MAPK signaling pathways

Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to descending pain facilitation in healthy and arthritic animals

Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis

Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

Accumbens nNOS Interneurons Regulate Cocaine Relapse

Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation

Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

An antagonist-based two-photon fluorogenic probe for imaging metabotropic glutamate receptor 5 in neuronal cells

Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5

Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer

Inhibition of mGluR5 ameliorates lipid accumulation and inflammation in HepG2 cells

Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

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