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Clinical Studies on Drug–Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation

Clinical pharmacology and therapeutics, 2019-06, Vol.105 (6), p.1345-1361

2019

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Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism

Anesthesiology (Philadelphia), 2015-11, Vol.123 (5), p.1142-1153

2015

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Pharmacokinetics

Biochemical pharmacology, 2014-01, Vol.87 (1), p.93-120

2014

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From Endogenous Compounds as Biomarkers to Plasma‐Derived Nanovesicles as Liquid Biopsy; Has the Golden Age of Translational Pharmacokinetics‐Absorption, Distribution, Metabolism, Excretion‐Drug–Drug Interaction Science Finally Arrived?

Clinical pharmacology and therapeutics, 2019-06, Vol.105 (6), p.1407-1420

2019

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Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?

Clinical pharmacokinetics, 2017-03, Vol.56 (3), p.273-285

2017

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Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates

Clinical pharmacology and therapeutics, 2019-03, Vol.105 (3), p.719-729

2019

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Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?

Critical care (London, England), 2013-05, Vol.17 (3), p.R84-R84

2013

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Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

The Journal of pharmacology and experimental therapeutics, 2017-03, Vol.360 (3), p.484-495

2017

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Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Anesthesiology (Philadelphia), 2022-02, Vol.136 (2), p.279-292

2022

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Fast intracellular dissolution and persistent cellular uptake of silver nanoparticles in CHO-K1 cells: implication for cytotoxicity

Nanotoxicology, 2015-03, Vol.9 (2), p.181-189

2015

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Renal Clearance and Degradation of Glutathione-Coated Copper Nanoparticles

Bioconjugate chemistry, 2015-03, Vol.26 (3), p.511-519

2015

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Renal Clearance in Newborns and Infants: Predictive Performance of Population‐Based Modeling for Drug Development

Clinical pharmacology and therapeutics, 2019-06, Vol.105 (6), p.1462-1470

2019

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Are Standard Dosing Regimens of Ceftriaxone Adapted for Critically Ill Patients with Augmented Creatinine Clearance?

Antimicrobial agents and chemotherapy, 2019-03, Vol.63 (3)

2019

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Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists

Drug metabolism and disposition, 2015-12, Vol.43 (12), p.1917-1928

2015

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Identification of the Rate-Determining Process in the Hepatic Clearance of Atorvastatin in a Clinical Cassette Microdosing Study

Clinical pharmacology and therapeutics, 2011-10, Vol.90 (4), p.575-581

2011

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Vancomycin population pharmacokinetics during extracorporeal membrane oxygenation therapy: a matched cohort study

Critical care (London, England), 2014-11, Vol.18 (6), p.632-632, Article 632

2014

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Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity

Drug metabolism and disposition, 2021-04, Vol.49 (4), p.305-313

2021

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Allometry Is a Reasonable Choice in Pediatric Drug Development

Journal of clinical pharmacology, 2017-04, Vol.57 (4), p.469-475

2017

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Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients: a population pharmacokinetic analysis

Pharmacogenetics and genomics, 2013-05, Vol.23 (5), p.251-261

2013

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Clinical Investigation of Metabolic and Renal Clearance Pathways Contributing to the Elimination of Fevipiprant Using Probenecid as Perpetrator

Drug metabolism and disposition, 2021-05, Vol.49 (5), p.389-394

2021

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Emerging Evidence of the Impact of Kidney Disease on Drug Metabolism and Transport

Clinical pharmacology and therapeutics, 2008-06, Vol.83 (6), p.898-903

2008

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Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

European journal of pharmaceutical sciences, 2016-10, Vol.94, p.59-71

2016

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Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans

Toxicology and applied pharmacology, 2018-07, Vol.351, p.32-45

2018

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Concepts of Lactate Metabolic Clearance Rate and Lactate Clamp for Metabolic Inquiry: A Mini-Review

Nutrients, 2023-07, Vol.15 (14), p.3213

2023

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Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds

Critical care (London, England), 2014-11, Vol.18 (6), p.657-657, Article 657

2014

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Clinical Studies on Drug–Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation

Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism

Pharmacokinetics

From Endogenous Compounds as Biomarkers to Plasma‐Derived Nanovesicles as Liquid Biopsy; Has the Golden Age of Translational Pharmacokinetics‐Absorption, Distribution, Metabolism, Excretion‐Drug–Drug Interaction Science Finally Arrived?

Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?

Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates

Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Fast intracellular dissolution and persistent cellular uptake of silver nanoparticles in CHO-K1 cells: implication for cytotoxicity

Renal Clearance and Degradation of Glutathione-Coated Copper Nanoparticles

Renal Clearance in Newborns and Infants: Predictive Performance of Population‐Based Modeling for Drug Development

Are Standard Dosing Regimens of Ceftriaxone Adapted for Critically Ill Patients with Augmented Creatinine Clearance?

Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists

Identification of the Rate-Determining Process in the Hepatic Clearance of Atorvastatin in a Clinical Cassette Microdosing Study

Vancomycin population pharmacokinetics during extracorporeal membrane oxygenation therapy: a matched cohort study

Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity

Allometry Is a Reasonable Choice in Pediatric Drug Development

Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients: a population pharmacokinetic analysis

Clinical Investigation of Metabolic and Renal Clearance Pathways Contributing to the Elimination of Fevipiprant Using Probenecid as Perpetrator

Emerging Evidence of the Impact of Kidney Disease on Drug Metabolism and Transport

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans

Concepts of Lactate Metabolic Clearance Rate and Lactate Clamp for Metabolic Inquiry: A Mini-Review

Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds

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