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From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology

Medicinal research reviews, 2021-09, Vol.41 (5), p.2606-2633

2021

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Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

European journal of medicinal chemistry, 2022-10, Vol.240, p.114606-114606, Article 114606

2022

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Coumarin linked heterocyclic hybrids: A promising approach to develop multi target drugs for Alzheimer's disease

Journal of molecular structure, 2021-10, Vol.1241, p.130618, Article 130618

2021

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Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer’s disease

Bioorganic & medicinal chemistry, 2022-10, Vol.71, p.116952-116952, Article 116952

2022

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A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease

European journal of medicinal chemistry, 2018-05, Vol.152, p.570-589

2018

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A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease

European journal of medicinal chemistry, 2017-03, Vol.128, p.332-345

2017

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Targeting Lewy body dementia with neflamapimod‐rasagiline hybrids

Archiv der Pharmazie (Weinheim), 2024-06, Vol.357 (6), p.e2300525-n/a

2024

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Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives

International journal of molecular sciences, 2021-06, Vol.22 (12), p.6359

2021

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Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds

European journal of medicinal chemistry, 2018-05, Vol.152, p.600-614

2018

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Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

European journal of medicinal chemistry, 2018-10, Vol.158, p.463-477

2018

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Tacrine – Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems

Bioorganic chemistry, 2021-02, Vol.107, p.104596, Article 104596

2021

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Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer’s Disease Drug Discovery

ACS medicinal chemistry letters, 2018-03, Vol.9 (3), p.171-176

2018

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Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases

Current neuropharmacology, 2020-01, Vol.18 (5), p.348-407

2020

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Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

European journal of medicinal chemistry, 2019-01, Vol.162, p.234-248

2019

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Multi-Target Directed Drugs as a Modern Approach for Drug Design Towards Alzheimer's Disease: An Update

Current medicinal chemistry, 2018-01, Vol.25 (29), p.3491-3525

2018

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Inhibition of BACE1, MAO‐B, cholinesterase enzymes, and anti‐amyloidogenic potential of selected natural phytoconstituents: Multi‐target‐directed ligand approach

Journal of food biochemistry, 2021-01, Vol.45 (1), p.e13571-n/a

2021

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Design, synthesis and biological evaluation of novel indanones derivatives as potent acetylcholinesterase/monoamine oxidase B inhibitors

Future medicinal chemistry, 2023-10, Vol.15 (20), p.1823-1841

2023

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Multi-Target-Directed Ligands as an Effective Strategy for the Treatment of Alzheimer’s Disease

Current medicinal chemistry, 2022-01, Vol.29 (10), p.1757-1803

2022

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Development of quinazolinone and vanillin acrylamide hybrids as multi-target directed ligands against Alzheimer's disease and mechanistic insights into their binding with acetylcholinesterase

Journal of biomolecular structure & dynamics, 2023-12, Vol.ahead-of-print (ahead-of-print), p.1-18

2023

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Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents

European journal of medicinal chemistry, 2022-03, Vol.231, p.114152-114152, Article 114152

2022

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Hybridization Approach to Drug Discovery Inhibiting Mycobacterium tuberculosis-An Overview

Current topics in medicinal chemistry, 2021-04, Vol.21 (9), p.777-788

2021

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Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease

European journal of medicinal chemistry, 2023-03, Vol.250, p.115169-115169, Article 115169

2023

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Editorial: Multi-target directed ligands for the treatment of cancer

Frontiers in oncology, 2022-08, Vol.12, p.980141-980141

2022

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From tryptamine to the discovery of efficient multi-target directed ligands against cholinesterase-associated neurodegenerative disorders

Frontiers in pharmacology, 2022-11, Vol.13, p.1036030-1036030

2022

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Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors

European journal of medicinal chemistry, 2020-11, Vol.205, p.112650-112650, Article 112650

2020

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From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

Coumarin linked heterocyclic hybrids: A promising approach to develop multi target drugs for Alzheimer's disease

Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer’s disease

A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease

A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease

Targeting Lewy body dementia with neflamapimod‐rasagiline hybrids

Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives

Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

Tacrine – Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems

Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer’s Disease Drug Discovery

Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

Multi-Target Directed Drugs as a Modern Approach for Drug Design Towards Alzheimer's Disease: An Update

Inhibition of BACE1, MAO‐B, cholinesterase enzymes, and anti‐amyloidogenic potential of selected natural phytoconstituents: Multi‐target‐directed ligand approach

Design, synthesis and biological evaluation of novel indanones derivatives as potent acetylcholinesterase/monoamine oxidase B inhibitors

Multi-Target-Directed Ligands as an Effective Strategy for the Treatment of Alzheimer’s Disease

Development of quinazolinone and vanillin acrylamide hybrids as multi-target directed ligands against Alzheimer's disease and mechanistic insights into their binding with acetylcholinesterase

Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents

Hybridization Approach to Drug Discovery Inhibiting Mycobacterium tuberculosis-An Overview

Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease

Editorial: Multi-target directed ligands for the treatment of cancer

From tryptamine to the discovery of efficient multi-target directed ligands against cholinesterase-associated neurodegenerative disorders

Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors

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