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Targeting the Proprotein Convertase Subtilisin/Kexin Type 9 for the Treatment of Dyslipidemia and Atherosclerosis

Journal of the American College of Cardiology, 2013-10, Vol.62 (16), p.1401-1408

2013

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Non-oxidative vs Oxidative Forms of Modified Low-density Lipoprotein: What is More Important in Atherogenesis?

Current medicinal chemistry, 2024-01, Vol.31 (17), p.2309-2313

2024

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The LDL receptor

Arteriosclerosis, thrombosis, and vascular biology, 2009-04, Vol.29 (4), p.431-438

2009

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Existing and emerging therapies for the treatment of familial hypercholesterolemia

Journal of lipid research, 2021-01, Vol.62, p.100060, Article 100060

Rosenson, Robert S.

2021

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Proteolysis of the low‐density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases

FEBS letters, 2023-06, Vol.597 (11), p.1489-1502

2023

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ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia

The New England journal of medicine, 2017-07, Vol.377 (3), p.296-297

2017

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Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen

Journal of lipid research, 2022-01, Vol.63 (1), p.100160, Article 100160

2022

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TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: Crosstalk between NF-κB and PPAR-γ

Journal of molecular and cellular cardiology, 2014-07, Vol.72, p.85-94

2014

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Clinical implications of discordance between low-density lipoprotein cholesterol and particle number

Journal of clinical lipidology, 2011-03, Vol.5 (2), p.105-113

2011

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The Reelin Receptors Apolipoprotein E receptor 2 (ApoER2) and VLDL Receptor

International journal of molecular sciences, 2018-10, Vol.19 (10), p.3090

2018

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Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis

Circulation (New York, N.Y.), 2022-03, Vol.145 (9), p.675-687

2022

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Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels: Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers and Hypercholesterolemic Subjects on Statins

Journal of the American College of Cardiology, 2012-11, Vol.60 (19), p.1888-1898

2012

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A novel insight into the nature of modified low-density lipoproteins and their role in atherosclerosis

Vessel Plus, 2023, Vol.7, p.3

2023

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Modified low-density lipoproteins as biomarkers in diabetes and metabolic syndrome

Frontiers in bioscience, 2018-01, Vol.23 (7), p.1220-1240, Article 4640

2018

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Macrophage Sortilin Promotes LDL Uptake, Foam Cell Formation, and Atherosclerosis

Circulation research, 2015-02, Vol.116 (5), p.789-796

2015

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Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis

Oxidative medicine and cellular longevity, 2020, Vol.2020 (2020), p.1-14

2020

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LDL binding to cell receptors and extracellular matrix is proatherogenic in obesity but improves after bariatric surgery

Journal of lipid research, 2023-11, Vol.64 (11), p.100451-100451, Article 100451

2023

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New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol

Arteriosclerosis, thrombosis, and vascular biology, 2023-07, Vol.43 (7), p.1219-1233

2023

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Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation

The Journal of biological chemistry, 2013-03, Vol.288 (12), p.8279-8288

2013

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The Mediterranean Diet decreases LDL atherogenicity in high cardiovascular risk individuals: a randomized controlled trial

Molecular nutrition & food research, 2017-09, Vol.61 (9), p.1601015-n/a

2017

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The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

European heart journal, 2015-01, Vol.36 (1), p.51-59

2015

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Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders

Journal of Molecular Medicine, 2016-07, Vol.94 (7), p.739-746

Mahley, Robert W.

2016

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Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

Diabetes (New York, N.Y.), 2016-10, Vol.65 (10), p.3171-3184

2016

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A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake

The Journal of biological chemistry, 2010-04, Vol.285 (17), p.12882-12891

2010

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Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis

JAMA : the journal of the American Medical Association, 2016-09, Vol.316 (12), p.1289

2016

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Targeting the Proprotein Convertase Subtilisin/Kexin Type 9 for the Treatment of Dyslipidemia and Atherosclerosis

Non-oxidative vs Oxidative Forms of Modified Low-density Lipoprotein: What is More Important in Atherogenesis?

The LDL receptor

Existing and emerging therapies for the treatment of familial hypercholesterolemia

Proteolysis of the low‐density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia

Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen

TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: Crosstalk between NF-κB and PPAR-γ

Clinical implications of discordance between low-density lipoprotein cholesterol and particle number

The Reelin Receptors Apolipoprotein E receptor 2 (ApoER2) and VLDL Receptor

Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis

Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels: Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers and Hypercholesterolemic Subjects on Statins

A novel insight into the nature of modified low-density lipoproteins and their role in atherosclerosis

Modified low-density lipoproteins as biomarkers in diabetes and metabolic syndrome

Macrophage Sortilin Promotes LDL Uptake, Foam Cell Formation, and Atherosclerosis

Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis

LDL binding to cell receptors and extracellular matrix is proatherogenic in obesity but improves after bariatric surgery

New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol

Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation

The Mediterranean Diet decreases LDL atherogenicity in high cardiovascular risk individuals: a randomized controlled trial

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders

Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake

Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis

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