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Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs

Molecular cell, 2021-01, Vol.81 (1), p.25-37.e4

2021

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KCNQ-Encoded Potassium Channels as Therapeutic Targets

Annual review of pharmacology and toxicology, 2018-01, Vol.58, p.625

2018

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The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss

Human mutation, 2006-08, Vol.27 (8), p.786-795

2006

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Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy

American journal of human genetics, 2017-07, Vol.101 (1), p.65-74

2017

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Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

Nature genetics, 2013-03, Vol.45 (3), p.314-318

2013

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Neural KCNQ (Kv7) channels

British journal of pharmacology, 2009-04, Vol.156 (8), p.1185-1195

2009

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The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

Epilepsia (Copenhagen), 2012-03, Vol.53 (3), p.412-424

2012

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Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp

The Journal of neuroscience, 2019-01, Vol.39 (3), p.382-392

2019

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Voltage-gated potassium channels KCNQs: Structures, mechanisms, and modulations

Biochemical and biophysical research communications, 2023-12, Vol.689, p.149218-149218, Article 149218

2023

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Atomic basis for therapeutic activation of neuronal potassium channels

Nature communications, 2015-09, Vol.6 (1), p.8116, Article 8116

2015

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Functional and behavioral signatures of Kv7 activator drug subtypes

Epilepsia (Copenhagen), 2020-08, Vol.61 (8), p.1678-1690

2020

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KCNQ5 Controls Perivascular Adipose Tissue-Mediated Vasodilation

Hypertension (Dallas, Tex. 1979), 2024-03, Vol.81 (3), p.561

2024

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Driving with no brakes: molecular pathophysiology of Kv7 potassium channels

Physiology (Bethesda, Md.), 2011-10, Vol.26 (5), p.365-376

2011

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Oxidative modulation of voltage-gated potassium channels

Antioxidants & redox signaling, 2014-08, Vol.21 (6), p.933

2014

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KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3

Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (13), p.e2117640119-e2117640119

2022

Volltextzugriff (PDF)

Autism-associated mutations in K V 7 channels induce gating pore current

Proceedings of the National Academy of Sciences - PNAS, 2021-11, Vol.118 (45)

2021

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Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus

The Journal of neuroscience, 2015-06, Vol.35 (23), p.8829-8842

2015

Volltextzugriff (PDF)

Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype

Bioorganic & medicinal chemistry letters, 2022-09, Vol.71, p.128841-128841, Article 128841

2022

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Astroglial gap junctions strengthen hippocampal network activity by sustaining afterhyperpolarization via KCNQ channels

Cell reports (Cambridge), 2024-05, Vol.43 (5), p.114158, Article 114158

2024

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Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly

Arteriosclerosis, thrombosis, and vascular biology, 2020-05, Vol.40 (5), p.1207

2020

Volltextzugriff (PDF)

Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity

Arteriosclerosis, thrombosis, and vascular biology, 2014-04, Vol.34 (4), p.887

2014

Volltextzugriff (PDF)

SMIT (Sodium-Myo-Inositol Transporter) 1 Regulates Arterial Contractility Through the Modulation of Vascular Kv7 Channels

Arteriosclerosis, thrombosis, and vascular biology, 2020-10, Vol.40 (10), p.2468

2020

Volltextzugriff (PDF)

Treatment during a vulnerable developmental period rescues a genetic epilepsy

Nature medicine, 2015-12, Vol.21 (12), p.1436-1444

2015

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KV7 channelopathies

Pflügers Archiv, 2010-07, Vol.460 (2), p.277-288

2010

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Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries

Arteriosclerosis, thrombosis, and vascular biology, 2016-12, Vol.36 (12), p.2404

2016

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Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs

KCNQ-Encoded Potassium Channels as Therapeutic Targets

The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

Neural KCNQ (Kv7) channels

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp

Voltage-gated potassium channels KCNQs: Structures, mechanisms, and modulations

Atomic basis for therapeutic activation of neuronal potassium channels

Functional and behavioral signatures of Kv7 activator drug subtypes

KCNQ5 Controls Perivascular Adipose Tissue-Mediated Vasodilation

Driving with no brakes: molecular pathophysiology of Kv7 potassium channels

Oxidative modulation of voltage-gated potassium channels

KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3

Autism-associated mutations in K V 7 channels induce gating pore current

Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus

Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype

Astroglial gap junctions strengthen hippocampal network activity by sustaining afterhyperpolarization via KCNQ channels

Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly

Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity

SMIT (Sodium-Myo-Inositol Transporter) 1 Regulates Arterial Contractility Through the Modulation of Vascular Kv7 Channels

Treatment during a vulnerable developmental period rescues a genetic epilepsy

KV7 channelopathies

Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries

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