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Design and Synthesis of 4-flurophthalimides as potential anticonvulsant agents

Iranian journal of pharmaceutical research : IJPR, 2018-01, Vol.17 (3), p.896-905

2018

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Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors

European journal of medicinal chemistry, 2021-02, Vol.212, p.113122, Article 113122

2021

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Oral Tecovirimat for the Treatment of Smallpox

The New England journal of medicine, 2018-07, Vol.379 (1), p.44-53

2018

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[3 + 1] Mixed Cyclization: A Synthetic Route to Prepare Low-Symmetry Phthalocyanines

Journal of organic chemistry, 2022-06, Vol.87 (11), p.7213-7218

2022

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Synthesis, Antimicrobial, Antiquorum-Sensing, and Cytotoxic Activities of New Series of Isoindoline-1,3-dione, Pyrazolo[5,1-a]isoindole, and Pyridine Derivatives

Archiv der Pharmazie (Weinheim), 2015-09, Vol.348 (9), p.666-680

2015

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Tecovirimat: First Global Approval

Drugs (New York, N.Y.), 2018-09, Vol.78 (13), p.1377-1382

Hoy, Sheridan M.

2018

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Continuous flow synthesis of the antiviral drug tecovirimat and related sp 3 -rich scaffolds

Organic & biomolecular chemistry, 2024-10, Vol.22 (41), p.8323-8327

2024

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C 64 Nanographene Tetraimide-A Receptor for Phthalocyanines with Subnanomolar Affinity

Angewandte Chemie International Edition, 2023-06, Vol.62 (25), p.e202302032

2023

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CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia

Journal of medicinal chemistry, 2021-02, Vol.64 (4), p.1835-1843

2021

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Rhodium-Catalyzed [3 + 2] Annulation of Cyclic N‑Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones

Journal of organic chemistry, 2017-04, Vol.82 (7), p.3359-3367

2017

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An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy

Nature communications, 2016-11, Vol.7 (1), p.13443-13443, Article 13443

2016

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AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13807-13829

2021

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A Coupling of Benzamides and Donor/Acceptor Diazo Compounds To Form γ‑Lactams via Rh(III)-Catalyzed C–H Activation

Journal of the American Chemical Society, 2013-04, Vol.135 (14), p.5364-5367

2013

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Copper-Mediated Tandem Oxidative C(sp2)–H/C(sp)–H Alkynylation and Annulation of Arenes with Terminal Alkynes

Organic letters, 2014-06, Vol.16 (11), p.2884-2887

2014

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.4071-4088

2021

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The Mpro structure-based modifications of ebselen derivatives for improved antiviral activity against SARS-CoV-2 virus

Bioorganic chemistry, 2021-12, Vol.117, p.105455-105455, Article 105455

2021

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Synthesis, characterization, anticancer, antimicrobial and carbonic anhydrase inhibition profiles of novel (3aR,4S,7R,7aS)-2-(4-((E)-3-(3-aryl)acryloyl) phenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione derivatives

Bioorganic chemistry, 2017-02, Vol.70, p.118-125

2017

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Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity

The Journal of pharmacology and experimental therapeutics, 2010-07, Vol.334 (1), p.171

2010

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Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys

PloS one, 2011-08, Vol.6 (8), p.e23237

2011

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Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy

Nano letters, 2018-05, Vol.18 (5), p.3250-3258

2018

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Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line

Drug development research, 2022-09, Vol.83 (6), p.1331-1341

2022

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Recent Developments in Isoindole Chemistry

Synthesis (Stuttgart), 2023-02, Vol.55 (4), p.519-546

2023

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Inhibitory interactions of the 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one scaffold with Bunyavirales cap-snatching endonucleases expose relevant drug design features

European journal of medicinal chemistry, 2024-06, Vol.272, p.116467-116467, Article 116467

2024

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Structural basis for allosteric PARP-1 retention on DNA breaks

Science (American Association for the Advancement of Science), 2020-04, Vol.368 (6486)

2020

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First clinical study using HCV protease inhibitor danoprevir to treat COVID-19 patients

Medicine (Baltimore), 2020-11, Vol.99 (48), p.e23357

2020

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Design and Synthesis of 4-flurophthalimides as potential anticonvulsant agents

Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors

Oral Tecovirimat for the Treatment of Smallpox

[3 + 1] Mixed Cyclization: A Synthetic Route to Prepare Low-Symmetry Phthalocyanines

Synthesis, Antimicrobial, Antiquorum-Sensing, and Cytotoxic Activities of New Series of Isoindoline-1,3-dione, Pyrazolo[5,1-a]isoindole, and Pyridine Derivatives

Tecovirimat: First Global Approval

Continuous flow synthesis of the antiviral drug tecovirimat and related sp 3 -rich scaffolds

C 64 Nanographene Tetraimide-A Receptor for Phthalocyanines with Subnanomolar Affinity

CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia

Rhodium-Catalyzed [3 + 2] Annulation of Cyclic N‑Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones

An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy

AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2

A Coupling of Benzamides and Donor/Acceptor Diazo Compounds To Form γ‑Lactams via Rh(III)-Catalyzed C–H Activation

Copper-Mediated Tandem Oxidative C(sp2)–H/C(sp)–H Alkynylation and Annulation of Arenes with Terminal Alkynes

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

The Mpro structure-based modifications of ebselen derivatives for improved antiviral activity against SARS-CoV-2 virus

Synthesis, characterization, anticancer, antimicrobial and carbonic anhydrase inhibition profiles of novel (3aR,4S,7R,7aS)-2-(4-((E)-3-(3-aryl)acryloyl) phenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione derivatives

Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity

Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys

Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy

Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line

Recent Developments in Isoindole Chemistry

Inhibitory interactions of the 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one scaffold with Bunyavirales cap-snatching endonucleases expose relevant drug design features

Structural basis for allosteric PARP-1 retention on DNA breaks

First clinical study using HCV protease inhibitor danoprevir to treat COVID-19 patients

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