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Perfluorooctane sulfonate acute exposure stimulates insulin secretion via GPR40 pathway

The Science of the total environment, 2020-07, Vol.726, p.138498-138498, Article 138498

2020

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GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson’s disease animal models

Pharmacological research, 2024-11, Vol.209, p.107432, Article 107432

2024

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The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections

Frontiers in immunology, 2020-09, Vol.11, p.573019-573019

2020

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Lauric Acid Alleviates Neuroinflammatory Responses by Activated Microglia: Involvement of the GPR40-Dependent Pathway

Neurochemical research, 2018-09, Vol.43 (9), p.1723-1735

2018

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Effect of medium chain fatty acid in human health and disease

Journal of functional foods, 2021-12, Vol.87, p.104724, Article 104724

2021

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A high-fat diet enriched in medium chain triglycerides triggers hepatic thermogenesis and improves metabolic health in lean and obese mice

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020-03, Vol.1865 (3), p.158582-158582, Article 158582

2020

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Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis

Cell metabolism, 2018-02, Vol.27 (2), p.419-427.e4

2018

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Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner

Molecular and cellular endocrinology, 2018-09, Vol.472, p.117-125

2018

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Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation

Bioorganic & medicinal chemistry letters, 2019-07, Vol.29 (14), p.1761-1764

2019

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FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity

Bioorganic & medicinal chemistry letters, 2021-06, Vol.41, p.127969-127969, Article 127969

2021

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Docosahexaenoic acid modulates brain-derived neurotrophic factor via GPR40 in the brain and alleviates diabesity-associated learning and memory deficits in mice

Neurobiology of disease, 2018-10, Vol.118, p.94-107

2018

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(1R,2R,4R)-N-((4-((4-(2-Carboxyethyl)phenoxy)methyl)thiophen-2-yl)methyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-aminium Chloride

MolBank, 2023-06, Vol.2023 (2), p.M1617

2023

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GW9508 ameliorates cognitive dysfunction via autophagy pathway in streptozotocin-induced mouse model of Alzheimer's disease

Fundamental & clinical pharmacology, 2024-03, Vol.38 (5), p.906-923

2024

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Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold

European journal of medicinal chemistry, 2019-10, Vol.179, p.608-622

2019

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Nutritional Signaling via Free Fatty Acid Receptors

International Journal of Molecular Sciences, 2016-03, Vol.17 (4), p.450-450

2016

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Free fatty acid receptors as therapeutic targets for the treatment of diabetes

Frontiers in pharmacology, 2014-11, Vol.5, p.236-236

2014

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Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice

Journal of endocrinology, 2019-02, Vol.240 (2), p.195-214

2019

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Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges

Medicinal research reviews, 2018-03, Vol.38 (2), p.381-425

2018

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Oral administration of linoleic acid immediately before glucose load ameliorates postprandial hyperglycemia

Frontiers in pharmacology, 2023-07, Vol.14, p.1197743-1197743

2023

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PPARγ signaling and emerging opportunities for improved therapeutics

Pharmacological research, 2016-09, Vol.111, p.76-85

2016

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G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

Diabetologia, 2012-10, Vol.55 (10), p.2682-2692

2012

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Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

Expert opinion on therapeutic patents, 2009-02, Vol.19 (2), p.237-264

2009

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Dipeptidyl peptidase-4 and GLP-1 interplay in STC-1 and GLUTag cell lines

Peptides (New York, N.Y. : 1980), 2020-12, Vol.134, p.170419-170419, Article 170419

2020

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Learn from failures and stay hopeful to GPR40, a GPCR target with robust efficacy, for therapy of metabolic disorders

Frontiers in pharmacology, 2022-10, Vol.13, p.1043828

2022

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First‐in‐human study of CPL207280, a novel G‐protein‐coupled receptor 40/free fatty acid receptor 1 agonist, in healthy volunteers after single and multiple administration

Diabetes, obesity & metabolism, 2024-04, Vol.26 (4), p.1376-1385

2024

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Perfluorooctane sulfonate acute exposure stimulates insulin secretion via GPR40 pathway

GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson’s disease animal models

The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections

Lauric Acid Alleviates Neuroinflammatory Responses by Activated Microglia: Involvement of the GPR40-Dependent Pathway

Effect of medium chain fatty acid in human health and disease

A high-fat diet enriched in medium chain triglycerides triggers hepatic thermogenesis and improves metabolic health in lean and obese mice

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis

Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner

Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation

FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity

Docosahexaenoic acid modulates brain-derived neurotrophic factor via GPR40 in the brain and alleviates diabesity-associated learning and memory deficits in mice

(1R,2R,4R)-N-((4-((4-(2-Carboxyethyl)phenoxy)methyl)thiophen-2-yl)methyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-aminium Chloride

GW9508 ameliorates cognitive dysfunction via autophagy pathway in streptozotocin-induced mouse model of Alzheimer's disease

Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold

Nutritional Signaling via Free Fatty Acid Receptors

Free fatty acid receptors as therapeutic targets for the treatment of diabetes

Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice

Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges

Oral administration of linoleic acid immediately before glucose load ameliorates postprandial hyperglycemia

PPARγ signaling and emerging opportunities for improved therapeutics

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

Dipeptidyl peptidase-4 and GLP-1 interplay in STC-1 and GLUTag cell lines

Learn from failures and stay hopeful to GPR40, a GPCR target with robust efficacy, for therapy of metabolic disorders

First‐in‐human study of CPL207280, a novel G‐protein‐coupled receptor 40/free fatty acid receptor 1 agonist, in healthy volunteers after single and multiple administration

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