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Inhibition of Dimethylarginine Dimethylaminohydrolase (DDAH) Enzymes as an Emerging Therapeutic Strategy to Target Angiogenesis and Vasculogenic Mimicry in Cancer

Frontiers in oncology, 2020-01, Vol.9, p.1455-1455

2020

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Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice

Frontiers in physiology, 2020-11, Vol.11, p.597559-597559

2020

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Molecular dynamics simulations of adsorption behavior of DDAH, NaOL and mixed DDAH/NaOL surfactants on muscovite (001) surface in aqueous solution

Journal of molecular graphics & modelling, 2022-06, Vol.113, p.108161-108161, Article 108161

2022

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Molecular dynamics simulation study of the interaction of mixed cationic/anionic surfactants with muscovite

Applied surface science, 2015-02, Vol.327, p.364-370

2015

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Esomeprazole covalently interacts with the cardiovascular enzyme dimethylarginine dimethylaminohydrolase: Insights into the cardiovascular risk of proton pump inhibitors

Biochimica et biophysica acta. General subjects, 2022-08, Vol.1866 (8), p.130149-130149, Article 130149

2022

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Renal asymmetric dimethylarginine inhibits fibrosis

FEBS open bio, 2020-10, Vol.10 (10), p.2003-2009

2020

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Dietary Supplementation of Caulerpa racemosa Ameliorates Cardiometabolic Syndrome via Regulation of PRMT-1/DDAH/ADMA Pathway and Gut Microbiome in Mice

Nutrients, 2023-02, Vol.15 (4), p.909

2023

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The Second Life of Methylarginines as Cardiovascular Targets

International journal of molecular sciences, 2019-09, Vol.20 (18), p.4592

2019

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Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings

International journal of molecular sciences, 2020-02, Vol.21 (5), p.1641

2020

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The iridoid loganic acid and anthocyanins from the cornelian cherry (Cornus mas L.) fruit increase the plasma l-arginine/ADMA ratio and decrease levels of ADMA in rabbits fed a high-cholesterol diet

Phytomedicine (Stuttgart), 2019-01, Vol.52, p.1-11

2019

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Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAH II/eNOS/NO pathway

Chinese journal of natural medicines, 2022-01, Vol.20 (1), p.22-32

2022

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Altered expression of the L-arginine/nitric oxide pathway in ovarian cancer: metabolic biomarkers and biological implications

BMC cancer, 2023-09, Vol.23 (1), p.1-844, Article 844

2023

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miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia

Biochemical journal, 2014-08, Vol.462 (1), p.103-112

2014

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Cornelian cherry consumption increases the l-arginine/ADMA ratio, lowers ADMA and SDMA levels in the plasma, and enhances the aorta glutathione level in rabbits fed a high-cholesterol diet

Journal of functional foods, 2017-07, Vol.34, p.189-196

2017

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Role of the PRMT–DDAH–ADMA axis in the regulation of endothelial nitric oxide production

Pharmacological research, 2009-12, Vol.60 (6), p.461-465

2009

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The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer's Disease

Journal of clinical medicine, 2017-05, Vol.6 (5), p.55

2017

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Curcumin attenuates endothelial cell fibrosis through inhibiting endothelial–interstitial transformation

Clinical and experimental pharmacology & physiology, 2020-07, Vol.47 (7), p.1182-1192

2020

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Esophageal Squamous Cell Carcinoma Is Accompanied by Local and Systemic Changes in L-arginine/NO Pathway

International journal of molecular sciences, 2020-08, Vol.21 (17), p.6282

2020

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Asymmetric dimethylarginine, endothelial dysfunction and renal disease

International Journal of Molecular Sciences, 2012-09, Vol.13 (9), p.11288-11311

2012

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Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo

Angiogenesis (London), 2018-11, Vol.21 (4), p.737-749

2018

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Amidine-based bioactive compounds for the regulation of arginine metabolism

Mini reviews in medicinal chemistry, 2013-07, Vol.13 (9), p.1305-1310

2013

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Positive Effects of Melatonin on Renal Nitric Oxide-Asymmetric Dimethylarginine Metabolism in Fructose-Fed Rats

Metabolic syndrome and related disorders, 2021-04, Vol.19 (3), p.120-126

2021

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Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension

The FASEB journal, 2005-07, Vol.19 (9), p.1175-1177

2005

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The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis

The Journal of pathology, 2013-01, Vol.229 (2), p.242-249

2013

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Inhibition of Dimethylarginine Dimethylaminohydrolase (DDAH) Enzymes as an Emerging Therapeutic Strategy to Target Angiogenesis and Vasculogenic Mimicry in Cancer

Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice

Molecular dynamics simulations of adsorption behavior of DDAH, NaOL and mixed DDAH/NaOL surfactants on muscovite (001) surface in aqueous solution

Molecular dynamics simulation study of the interaction of mixed cationic/anionic surfactants with muscovite

Esomeprazole covalently interacts with the cardiovascular enzyme dimethylarginine dimethylaminohydrolase: Insights into the cardiovascular risk of proton pump inhibitors

Renal asymmetric dimethylarginine inhibits fibrosis

Dietary Supplementation of Caulerpa racemosa Ameliorates Cardiometabolic Syndrome via Regulation of PRMT-1/DDAH/ADMA Pathway and Gut Microbiome in Mice

The Second Life of Methylarginines as Cardiovascular Targets

Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings

The iridoid loganic acid and anthocyanins from the cornelian cherry (Cornus mas L.) fruit increase the plasma l-arginine/ADMA ratio and decrease levels of ADMA in rabbits fed a high-cholesterol diet

L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs

Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAH II/eNOS/NO pathway

Altered expression of the L-arginine/nitric oxide pathway in ovarian cancer: metabolic biomarkers and biological implications

miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia

Cornelian cherry consumption increases the l-arginine/ADMA ratio, lowers ADMA and SDMA levels in the plasma, and enhances the aorta glutathione level in rabbits fed a high-cholesterol diet

Role of the PRMT–DDAH–ADMA axis in the regulation of endothelial nitric oxide production

The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer's Disease

Curcumin attenuates endothelial cell fibrosis through inhibiting endothelial–interstitial transformation

Esophageal Squamous Cell Carcinoma Is Accompanied by Local and Systemic Changes in L-arginine/NO Pathway

Asymmetric dimethylarginine, endothelial dysfunction and renal disease

Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo

Amidine-based bioactive compounds for the regulation of arginine metabolism

Positive Effects of Melatonin on Renal Nitric Oxide-Asymmetric Dimethylarginine Metabolism in Fructose-Fed Rats

Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension

The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis

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