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Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.92

2010

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Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1217-1228

2016

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Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

Drug metabolism and disposition, 2009-10, Vol.37 (10), p.2087

2009

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Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P‐Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Clinical pharmacology and therapeutics, 2018-12, Vol.104 (6), p.1249-1259

2018

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The Potential for Pharmacokinetic Interactions Between Cannabis Products and Conventional Medications

Journal of clinical psychopharmacology, 2019-09, Vol.39 (5), p.462

2019

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Evaluation of Mutual Drug–Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method

Basic & clinical pharmacology & toxicology, 2016-09, Vol.119 (3), p.284-290

2016

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Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

PloS one, 2015-07, Vol.10 (7), p.e0132992

2015

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A Highly Selective Ratiometric Two-Photon Fluorescent Probe for Human Cytochrome P450 1A

Journal of the American Chemical Society, 2015-11, Vol.137 (45), p.14488-14495

2015

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Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors

Journal of medicinal chemistry, 2017-08, Vol.60 (15), p.6678-6692

2017

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Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone

Drug metabolism and disposition, 2015-02, Vol.43 (2), p.182-189

2015

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3D Spheroid Primary Human Hepatocytes for Prediction of Cytochrome P450 and Drug Transporter Induction

Clinical pharmacology and therapeutics, 2023-06, Vol.113 (6), p.1284-1294

2023

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Structure−Function Relationships of Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 Flavonoid Derivatives

Chemical research in toxicology, 2010-12, Vol.23 (12), p.1921-1935

2010

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Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke

Molecular and cellular biochemistry, 2014-06, Vol.391 (1-2), p.127-136

2014

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Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity

The pharmacogenomics journal, 2020-04, Vol.20 (2), p.192-201

2020

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Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450s

PloS one, 2014-02, Vol.9 (2), p.e87058-e87058

2014

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The inhibition of CYP1A2, CYP2C9, and CYP2D6 by pterostilbene in human liver microsomes

Pharmazie, 2021-04, Vol.76 (4), p.155-158

2021

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants

Clinical pharmacology and therapeutics, 2023-07, Vol.114 (1), p.51-68

2023

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Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro

Drug metabolism and disposition, 2023-03, Vol.51 (3), p.293-305

2023

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CYP450 Genotype/Phenotype Concordance in Mexican Amerindian Indigenous Populations-Where to from Here for Global Precision Medicine?

Omics (Larchmont, N.Y.), 2017-09, Vol.21 (9), p.509

2017

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Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

Biochemistry (Easton), 2018-02, Vol.57 (5), p.817-826

2018

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Pogostone inhibits the activity of CYP3A4, 2C9, and 2E1 in vitro

Pharmaceutical biology, 2021-01, Vol.59 (1), p.530-534

2021

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Differential expression of cytochrome P450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma

PloS one, 2014-04, Vol.9 (4), p.e93261-e93261

2014

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Prediction of Cytochrome P450 Inhibition Using a Deep Learning Approach and Substructure Pattern Recognition

Journal of chemical information and modeling, 2024-04, Vol.64 (7), p.2528-2538

2024

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Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of the aryl hydrocarbon receptor

Toxicology and applied pharmacology, 2021-05, Vol.419, p.115502-115502, Article 115502

2021

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Inhibitory effects of sanguinarine on human liver cytochrome P450 enzymes

Food and chemical toxicology, 2013-06, Vol.56, p.392-397

2013

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