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The Rational Design of Selective Benzoxazepin Inhibitors of the α‑Isoform of Phosphoinositide 3‑Kinase Culminating in the Identification of (S)‑2-((2-(1-Isopropyl‑1H‑1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

Journal of medicinal chemistry, 2016-02, Vol.59 (3), p.985-1002

2016

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Gold-Catalyzed Synthesis of Tropone and Its Analogues via Oxidative Ring Expansion of Alkynyl Quinols

Organic letters, 2015-12, Vol.17 (23), p.5926-5929

2015

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Total Synthesis of Ovafolinins A and B: Unique Polycyclic Benzoxepin Lignans through a Cascade Cyclization

Angewandte Chemie International Edition, 2017-08, Vol.56 (32), p.9483-9486

2017

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One-Pot Synthesis of 5‑Amino-2,5-dihydro-1-benzoxepines: Access to Pharmacologically Active Heterocyclic Scaffolds

Journal of organic chemistry, 2015-05, Vol.80 (9), p.4683-4696

2015

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Sudachinoid- and Ichangensin-Type Limonoids from Citrus junos Downregulate Pro-Inflammatory Cytokines

International journal of molecular sciences, 2020-09, Vol.21 (18), p.6963

2020

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Pestalachlorides A–C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta

Bioorganic & medicinal chemistry, 2008-09, Vol.16 (17), p.7894-7899

2008

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FeCl3-catalyzed synthesis of functionally diverse dibenzo[b,f]oxepines and benzo[b]oxepines via alkyne-aldehyde metathesis

Organic & biomolecular chemistry, 2014-01, Vol.12 (1), p.57-61

2014

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Convenient one-pot synthesis, anti-mycobacterial and anticancer activities of novel benzoxepinoisoxazolones and pyrazolones

European journal of medicinal chemistry, 2014-04, Vol.76, p.460-469

2014

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Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs

European journal of medicinal chemistry, 2013-04, Vol.62, p.28-39

2013

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Subchronic Toxicity Studies of Cortex Dictamni Extracts in Mice and Its Potential Hepatotoxicity Mechanisms in Vitro

Molecules (Basel, Switzerland), 2018-09, Vol.23 (10), p.2486

2018

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A Novel Approach for C–C, C–N, and C–O Bond Formation Reactions: A Facile Synthesis of Benzophenazine, Quinoxaline, and Phenoxazine Derivatives via Ring Opening of Benzoxepines

Organic letters, 2014-01, Vol.16 (2), p.420-423

2014

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α‑Glucosidase Inhibitors from Malbranchea flavorosea

Journal of natural products (Washington, D.C.), 2017-01, Vol.80 (1), p.190-195

2017

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Psoromic Acid, a Lichen-Derived Molecule, Inhibits the Replication of HSV-1 and HSV-2, and Inactivates HSV-1 DNA Polymerase: Shedding Light on Antiherpetic Properties

Molecules (Basel, Switzerland), 2019-08, Vol.24 (16), p.2912

2019

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Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform

Journal of medicinal chemistry, 2011-11, Vol.54 (22), p.7815-7833

2011

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Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B

Organic letters, 2017-07, Vol.19 (13), p.3414-3417

2017

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Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.514-534

2018

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Nomilin targets the Keap1‐Nrf2 signalling and ameliorates the development of osteoarthritis

Journal of cellular and molecular medicine, 2020-08, Vol.24 (15), p.8579-8588

2020

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Cytochrome P450 Can Epoxidize an Oxepin to a Reactive 2,3-Epoxyoxepin Intermediate: Potential Insights into Metabolic Ring-Opening of Benzene

Molecules (Basel, Switzerland), 2020-10, Vol.25 (19), p.4542

2020

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New Metabolites and Bioactive Chlorinated Benzophenone Derivatives Produced by a Marine-Derived Fungus Pestalotiopsis heterocornis

Marine drugs, 2017-03, Vol.15 (3), p.69

2017

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hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala

Journal of natural products (Washington, D.C.), 2015-07, Vol.78 (7), p.1697-1707

2015

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Photocycloaddition of Arenes and Allenes

Journal of organic chemistry, 2013-07, Vol.78 (14), p.6890-6910

2013

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Synthesis of New Benzocyclotrimer Analogues: New Receptors for Tetramethylammonium Ion Recognition

Organic letters, 2015-06, Vol.17 (12), p.2912-2915

2015

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Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase

Journal of the American Chemical Society, 2012-05, Vol.134 (17), p.7384-7391

2012

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Dibenz[b,f]oxepin and Antimycobacterial Chalcone Constituents of Empetrum nigrum

Journal of natural products (Washington, D.C.), 2015-11, Vol.78 (11), p.2837-2840

2015

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Synthesis of Dibenzoxepine Lactams via a Cu-Catalyzed One-Pot Etherification/Aldol Condensation Cascade Reaction: Application toward the Total Synthesis of Aristoyagonine

Organic letters, 2013-09, Vol.15 (18), p.4718-4721

2013

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The Rational Design of Selective Benzoxazepin Inhibitors of the α‑Isoform of Phosphoinositide 3‑Kinase Culminating in the Identification of (S)‑2-((2-(1-Isopropyl‑1H‑1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

Gold-Catalyzed Synthesis of Tropone and Its Analogues via Oxidative Ring Expansion of Alkynyl Quinols

Total Synthesis of Ovafolinins A and B: Unique Polycyclic Benzoxepin Lignans through a Cascade Cyclization

One-Pot Synthesis of 5‑Amino-2,5-dihydro-1-benzoxepines: Access to Pharmacologically Active Heterocyclic Scaffolds

Sudachinoid- and Ichangensin-Type Limonoids from Citrus junos Downregulate Pro-Inflammatory Cytokines

Pestalachlorides A–C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta

FeCl3-catalyzed synthesis of functionally diverse dibenzo[b,f]oxepines and benzo[b]oxepines via alkyne-aldehyde metathesis

Convenient one-pot synthesis, anti-mycobacterial and anticancer activities of novel benzoxepinoisoxazolones and pyrazolones

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs

Subchronic Toxicity Studies of Cortex Dictamni Extracts in Mice and Its Potential Hepatotoxicity Mechanisms in Vitro

A Novel Approach for C–C, C–N, and C–O Bond Formation Reactions: A Facile Synthesis of Benzophenazine, Quinoxaline, and Phenoxazine Derivatives via Ring Opening of Benzoxepines

α‑Glucosidase Inhibitors from Malbranchea flavorosea

Psoromic Acid, a Lichen-Derived Molecule, Inhibits the Replication of HSV-1 and HSV-2, and Inactivates HSV-1 DNA Polymerase: Shedding Light on Antiherpetic Properties

Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform

Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B

Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity

Nomilin targets the Keap1‐Nrf2 signalling and ameliorates the development of osteoarthritis

Cytochrome P450 Can Epoxidize an Oxepin to a Reactive 2,3-Epoxyoxepin Intermediate: Potential Insights into Metabolic Ring-Opening of Benzene

New Metabolites and Bioactive Chlorinated Benzophenone Derivatives Produced by a Marine-Derived Fungus Pestalotiopsis heterocornis

hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala

Photocycloaddition of Arenes and Allenes

Synthesis of New Benzocyclotrimer Analogues: New Receptors for Tetramethylammonium Ion Recognition

Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase

Dibenz[b,f]oxepin and Antimycobacterial Chalcone Constituents of Empetrum nigrum

Synthesis of Dibenzoxepine Lactams via a Cu-Catalyzed One-Pot Etherification/Aldol Condensation Cascade Reaction: Application toward the Total Synthesis of Aristoyagonine

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