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Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway

Molecular cell, 2017-01, Vol.65 (2), p.247-259

2017

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Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

Nature communications, 2018-06, Vol.9 (1), p.2280-14, Article 2280

2018

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Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome

Science translational medicine, 2016-05, Vol.8 (338), p.338ra67

2016

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Structure of the FA core ubiquitin ligase closing the ID clamp on DNA

Nature structural & molecular biology, 2021-03, Vol.28 (3), p.300-309

2021

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Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age

American journal of hematology, 2013-11, Vol.88 (11), p.E283-E285

2013

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Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination

The EMBO journal, 2023-02, Vol.42 (3), p.e111898-n/a

2023

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Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

Science (American Association for the Advancement of Science), 2009-12, Vol.326 (5960), p.1698-1701

2009

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Zebrafish erythropoiesis and the utility of fish as models of anemia

Stem cell research & therapy, 2012-12, Vol.3 (6), p.55-55, Article 55

2012

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Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

Cell reports (Cambridge), 2019-01, Vol.26 (3), p.564-572.e5

2019

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A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2

Nucleic acids research, 2019-08, Vol.47 (14), p.7532-7547

2019

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Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

Cell stem cell, 2012-07, Vol.11 (1), p.36-49

2012

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Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair

Cell, 2007-04, Vol.129 (2), p.289-301

2007

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Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis

Haematologica (Roma), 2009-03, Vol.94 (3), p.395-408

2009

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The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

Nature cell biology, 2009-06, Vol.11 (6), p.761-768

2009

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The Prevalence of Anemia and Moderate-Severe Anemia in the US Population (NHANES 2003-2012)

PloS one, 2016-11, Vol.11 (11), p.e0166635

2016

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HIV-1 exploits the Fanconi anemia pathway for viral DNA integration

Cell reports (Cambridge), 2022-05, Vol.39 (8), p.110840-110840, Article 110840

2022

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Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

Nature (London), 2013-01, Vol.493 (7432), p.356-363

2013

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Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

Leukemia, 2019-07, Vol.33 (7), p.1759-1772

2019

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The diagnosis and management of the haematologic manifestations of lupus

Journal of autoimmunity, 2016-11, Vol.74, p.139-160

2016

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The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks

Nature communications, 2024-08, Vol.15 (1), p.7076-17

2024

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Evidence for subcomplexes in the Fanconi anemia pathway

Blood, 2006-09, Vol.108 (6), p.2072-2080

2006

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Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors

The Journal of cell biology, 2017-12, Vol.216 (12), p.4007-4026

2017

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Cyclin-Dependent Kinase-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity

Molecular and cellular biology, 2021-08, Vol.41 (8), p.e0023421-e0023421

2021

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Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

Nature (London), 2018-01, Vol.553 (7687), p.171-177

2018

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The RPA inhibitor HAMNO sensitizes Fanconi anemia pathway-deficient cells

Cell cycle (Georgetown, Tex.), 2022-07, Vol.21 (14), p.1468-1478

2022

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Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome

Structure of the FA core ubiquitin ligase closing the ID clamp on DNA

Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age

Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination

Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

Zebrafish erythropoiesis and the utility of fish as models of anemia

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair

Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

The Prevalence of Anemia and Moderate-Severe Anemia in the US Population (NHANES 2003-2012)

HIV-1 exploits the Fanconi anemia pathway for viral DNA integration

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

The diagnosis and management of the haematologic manifestations of lupus

The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks

Evidence for subcomplexes in the Fanconi anemia pathway

Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors

Cyclin-Dependent Kinase-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

The RPA inhibitor HAMNO sensitizes Fanconi anemia pathway-deficient cells

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