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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

Cell chemical biology, 2018-01, Vol.25 (1), p.88-99.e6

2018

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Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors

The New England journal of medicine, 2022-02, Vol.386 (8), p.735-743

2022

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PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies

Cell research, 2018-07, Vol.28 (7), p.779-781

2018

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Degradation of Bruton's tyrosine kinase mutants by PROTACs for potential treatment of ibrutinib-resistant non-Hodgkin lymphomas

Leukemia, 2019-08, Vol.33 (8), p.2105-2110

2019

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Role of Bruton's tyrosine kinase in B cells and malignancies

Molecular cancer, 2018-02, Vol.17 (1), p.57-57, Article 57

2018

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Targeting the C481S Ibrutinib-Resistance Mutation in Bruton’s Tyrosine Kinase Using PROTAC-Mediated Degradation

Biochemistry (Easton), 2018-07, Vol.57 (26), p.3564-3575

2018

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The Development of BTK Inhibitors: A Five-Year Update

Molecules (Basel, Switzerland), 2021-12, Vol.26 (23), p.7411

2021

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Clinical and biological implications of target occupancy in CLL treated with the BTK inhibitor acalabrutinib

Blood, 2020-07, Vol.136 (1), p.93-105

2020

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Structural mechanism for Bruton’s tyrosine kinase activation at the cell membrane

Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (19), p.9390-9399

2019

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Inhibition of Bruton’s Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer’s Disease

Journal of neuroimmune pharmacology, 2019-09, Vol.14 (3), p.448-461

2019

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Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL

Blood, 2018-09, Vol.132 (10), p.1039-1049

2018

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Scaffold‐Oriented Asymmetric Catalysis: Conformational Modulation of Transition State Multivalency during a Catalyst‐Controlled Assembly of a Pharmaceutically Relevant Atropisomer

Chemistry : a European journal, 2024-05, Vol.30 (30), p.e202401109-n/a

2024

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Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (3), p.126877-126877, Article 126877

2020

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New Means and Challenges in the Targeting of BTK

Clinical cancer research, 2024-06, Vol.30 (11), p.2333

2024

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BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID‐19 therapy

Journal of leukocyte biology, 2021-01, Vol.109 (1), p.49-53

2021

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Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI

Haematologica (Roma), 2018-12, Vol.103 (12), p.2097

2018

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Computational Investigation of the Covalent Inhibition Mechanism of Bruton’s Tyrosine Kinase by Ibrutinib

Journal of chemical information and modeling, 2024-04, Vol.64 (8), p.3488-3502

2024

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Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors

Leukemia, 2019-01, Vol.33 (1), p.75-87

2019

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Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (43), p.21539-21544

2019

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Bruton’s tyrosine kinase: an emerging targeted therapy in myeloid cells within the tumor microenvironment

Cancer Immunology, Immunotherapy, 2021-09, Vol.70 (9), p.2439-2451

2021

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IL‐6/p‐BTK/p‐ERK signaling mediates calcium phosphate‐induced pruritus

The FASEB journal, 2019-11, Vol.33 (11), p.12036-12046

2019

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Structure-Function Relationships of Covalent and Non-Covalent BTK Inhibitors

Frontiers in immunology, 2021-07, Vol.12, p.694853-694853

2021

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A Chemoproteomics Approach to Determine the Mechanism of Testicular Toxicity for the Bruton's Tyrosine Kinase Inhibitor CC-292

The Journal of pharmacology and experimental therapeutics, 2021-11, Vol.379 (2), p.166

2021

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Covalent docking-driven virtual screening of extensive small-molecule libraries against Bruton tyrosine kinase for the identification of highly selective and potent novel therapeutic candidates

Journal of molecular graphics & modelling, 2024-07, Vol.130, p.108762-108762, Article 108762

2024

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Resistance Mutations to BTK Inhibitors Originate From the NF-κB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway

Frontiers in immunology, 2021-06, Vol.12, p.689472-689472

2021

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