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Detection of Acetaminophen-Protein Adducts in Decedents with Suspected Opioid-Acetaminophen Combination Product Overdose

Journal of forensic sciences, 2016-09, Vol.61 (5), p.1301-1306

2016

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Removal of Acetaminophen-Protein Adducts by Autophagy Protects Against Acetaminophen-Induced Liver Injury in Mice

Journal of hepatology, 2016-08, Vol.65 (2), p.354-362

2016

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Role and mechanisms of autophagy in acetaminophen‐induced liver injury

Liver international, 2018-08, Vol.38 (8), p.1363-1374

2018

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Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

Toxicology and applied pharmacology, 2014-09, Vol.279 (3), p.266-274

2014

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Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver

Life sciences (1973), 2019-08, Vol.230, p.97-103

2019

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Population Pharmacokinetic Modeling of Acetaminophen Protein Adducts in Adults and Children

Journal of clinical pharmacology, 2020-05, Vol.60 (5), p.595-604

2020

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Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen

Journal of clinical pharmacology, 2019-10, Vol.59 (10), p.1291-1299

2019

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The Relationship Between Circulating Acetaminophen-Protein Adduct Concentrations and Alanine Aminotransferase Activities in Patients With and Without Acetaminophen Overdose and Toxicity

Journal of medical toxicology, 2019-07, Vol.15 (3), p.143-155

2019

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Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen

Clinical toxicology (Philadelphia, Pa.), 2016-03, Vol.54 (3), p.282-285

2016

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Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury

Cell biology and toxicology, 2022-06, Vol.38 (3), p.505-530

2022

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Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

Toxicology and applied pharmacology, 2013-06, Vol.269 (3), p.240-249

2013

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4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

Human & experimental toxicology, 2018-12, Vol.37 (12), p.1310-1322

2018

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Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

Archives of toxicology, 2021-04, Vol.95 (4), p.1463-1473

2021

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Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

Toxicology and applied pharmacology, 2012-11, Vol.264 (3), p.387-394

2012

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Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (52), p.18757-18762

2014

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The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice

Archives of toxicology, 2024-06, Vol.98 (6), p.1843-1858

2024

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Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options

Journal of Zhejiang University. B. Science, 2022-04, Vol.23 (4), p.265-285

2022

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Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

Liver international, 2012-01, Vol.32 (1), p.8-20

2012

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4-methylpyrazole protects against acetaminophen-induced acute kidney injury

Toxicology and applied pharmacology, 2020-12, Vol.409, p.115317-115317, Article 115317

2020

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Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing

British journal of clinical pharmacology, 2016-03, Vol.81 (3), p.562-568

2016

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Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?

Gene expression, 2021-06, Vol.20 (3), p.169-178

2021

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The development and hepatotoxicity of acetaminophen: reviewing over a century of progress

Drug metabolism reviews, 2020-10, Vol.52 (4), p.472-500

2020

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Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase

Toxicology and applied pharmacology, 2014-11, Vol.281 (1), p.58-66

2014

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Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5)

Journal of hepatology, 2020-03, Vol.72 (3), p.450-462

2020

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Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice

Toxicology letters, 2021-03, Vol.338, p.21-31

2021

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Detection of Acetaminophen-Protein Adducts in Decedents with Suspected Opioid-Acetaminophen Combination Product Overdose

Removal of Acetaminophen-Protein Adducts by Autophagy Protects Against Acetaminophen-Induced Liver Injury in Mice

Role and mechanisms of autophagy in acetaminophen‐induced liver injury

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver

Population Pharmacokinetic Modeling of Acetaminophen Protein Adducts in Adults and Children

Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen

The Relationship Between Circulating Acetaminophen-Protein Adduct Concentrations and Alanine Aminotransferase Activities in Patients With and Without Acetaminophen Overdose and Toxicity

Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen

Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice

Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

4-methylpyrazole protects against acetaminophen-induced acute kidney injury

Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing

Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?

The development and hepatotoxicity of acetaminophen: reviewing over a century of progress

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase

Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5)

Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice

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