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Pharmaco-metabonomic phenotyping and personalized drug treatment

Nature, 2006-04, Vol.440 (7087), p.1073-1077

2006

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Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

Pharmaceutical research, 2013-09, Vol.30 (9), p.2174-2187

2013

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Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away?

Journal of hepatology, 2017-12, Vol.67 (6), p.1324-1331

Lee, William M.

2017

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PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses

Pharmacogenetics and genomics, 2015-08, Vol.25 (8), p.416-426

2015

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Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (34), p.14728-14733

2009

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Enzyme‐MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy

Angewandte Chemie (International ed.), 2018-05, Vol.57 (20), p.5725-5730

International ed. in English, 2018

Volltextzugriff (PDF)

Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women

Clinical pharmacokinetics, 2020-01, Vol.59 (1), p.97-110

2020

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Cytochrome P450 2E1 and its roles in disease

Chemico-biological interactions, 2020-05, Vol.322, p.109056-109056, Article 109056

Guengerich, F. Peter

2020

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Determination of acetaminophen and its main metabolites in urine by capillary electrophoresis hyphenated to mass spectrometry

Talanta (Oxford), 2019-12, Vol.205, p.120108-120108, Article 120108

2019

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Simultaneous Voltammetric Determination of Acetaminophen and Isoniazid (Hepatotoxicity-Related Drugs) Utilizing Bismuth Oxide Nanorod Modified Screen-Printed Electrochemical Sensing Platforms

Analytical chemistry (Washington), 2017-02, Vol.89 (3), p.2170-2178

2017

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Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers

The Journal of pharmacology and experimental therapeutics, 2017-09, Vol.362 (3), p.431

2017

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Acetaminophen detoxification in cucumber plants via induction of glutathione S-transferases

The Science of the total environment, 2019-02, Vol.649, p.431-439

2019

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Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing

Toxicological sciences, 2021-08, Vol.182 (2), p.327-345

2021

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Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

Toxicology and applied pharmacology, 2013-06, Vol.269 (3), p.240-249

2013

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Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice

Archives of toxicology, 2022-01, Vol.96 (1), p.305-320

2022

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A systems approach reveals species differences in hepatic stress response capacity

Toxicological sciences, 2023-10, Vol.196 (1), p.112-125

2023

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Mechanisms of acetaminophen-induced liver necrosis

Handbook of experimental pharmacology, 2010 (196), p.369

2010

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Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease

Liver international, 2014-08, Vol.34 (7), p.e171-e179

2014

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Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway

Ecotoxicology and environmental safety, 2022-08, Vol.241, p.113773, Article 113773

2022

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Reactive Metabolites: Current and Emerging Risk and Hazard Assessments

Chemical research in toxicology, 2016-04, Vol.29 (4), p.505-533

2016

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Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2

Toxicological sciences, 2024-01, Vol.197 (1), p.53-68

2024

Volltextzugriff (PDF)

Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure

Toxicological sciences, 2021-02, Vol.180 (1), p.186-195

2021

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Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

Clinical pharmacokinetics, 2016-07, Vol.55 (7), p.833-847

2016

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St. John's Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation

Toxicological sciences, 2022-10, Vol.190 (1), p.54-63

2022

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On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay

Analytical chemistry (Washington), 2016-02, Vol.88 (3), p.1719-1727

2016

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Pharmaco-metabonomic phenotyping and personalized drug treatment

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away?

PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

Enzyme‐MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy

Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women

Cytochrome P450 2E1 and its roles in disease

Determination of acetaminophen and its main metabolites in urine by capillary electrophoresis hyphenated to mass spectrometry

Simultaneous Voltammetric Determination of Acetaminophen and Isoniazid (Hepatotoxicity-Related Drugs) Utilizing Bismuth Oxide Nanorod Modified Screen-Printed Electrochemical Sensing Platforms

Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers

Acetaminophen detoxification in cucumber plants via induction of glutathione S-transferases

Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice

A systems approach reveals species differences in hepatic stress response capacity

Mechanisms of acetaminophen-induced liver necrosis

Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease

Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway

Reactive Metabolites: Current and Emerging Risk and Hazard Assessments

Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2

Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure

Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

St. John's Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation

On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay

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