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Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

Cancer cell, 2012-12, Vol.22 (6), p.825-837

2012

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Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo

ChemMedChem, 2015-05, Vol.10 (5), p.815-826

2015

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Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

Cell, 2011-08, Vol.146 (3), p.471-484

2011

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Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

eLife, 2019-07, Vol.8

2019

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Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

PloS one, 2018-06, Vol.13 (6), p.e0198492-e0198492

2018

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7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase

eLife, 2024-06, Vol.13

2024

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

eLife, 2023-10, Vol.12

2023

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Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (20), p.7275-7280

2008

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Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

PloS one, 2018-12, Vol.13 (12), p.e0208641-e0208641

2018

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Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (9), p.3554-3559

2011

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Large-scale microRNA functional high-throughput screening identifies miR-515-3p and miR-519e-3p as inducers of human cardiomyocyte proliferation

iScience, 2023-05, Vol.26 (5), p.106593-106593, Article 106593

2023

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Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells

Cancer letters, 2020-06, Vol.479, p.61-70

2020

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A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

Cancer research (Chicago, Ill.), 2012-06, Vol.72 (11), p.2822-2832

2012

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Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4

PloS one, 2024-07, Vol.19 (7), p.e0302704

2024

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Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1

PLoS biology, 2017-06, Vol.15 (6), p.e2000784-e2000784

2017

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Substance P - a regulatory peptide with defense and repair functions. Results and perspectives for the fight against COVID-19

Frontiers in neurology, 2024-05, Vol.15, p.1370454

2024

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Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4

European journal of medicinal chemistry, 2021-01, Vol.209, p.112901-112901, Article 112901

2021

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Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

PloS one, 2023-02, Vol.18 (2), p.e0278325-e0278325

2023

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A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug‐Resistant Staphylococcus aureus

Angewandte Chemie International Edition, 2017-12, Vol.56 (49), p.15746-15750

International ed. in English, 2017

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Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

Sensors (Basel, Switzerland), 2009-07, Vol.9 (7), p.5423-5445

2009

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Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases

Biochemical journal, 2006-05, Vol.395 (3), p.483-491

2006

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Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth

Cancer research (Chicago, Ill.), 2011, Vol.71 (1), p.197-205

2011

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Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids

Chembiochem : a European journal of chemical biology, 2016-01, Vol.17 (1), p.90-101

2016

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Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach

Journal of medicinal chemistry, 2017-12, Vol.60 (24), p.10013-10025

2017

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Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo

Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis

Large-scale microRNA functional high-throughput screening identifies miR-515-3p and miR-519e-3p as inducers of human cardiomyocyte proliferation

Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells

A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1

Substance P - a regulatory peptide with defense and repair functions. Results and perspectives for the fight against COVID-19

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4

Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug‐Resistant Staphylococcus aureus

Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases

Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth

Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids

Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

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