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Protein Quantification by LC–MS: A Decade of Progress Through the Pages of Bioanalysis

Bioanalysis, 2019-04, Vol.11 (7), p.629-644

van de Merbel, Nico C

2019

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Analytical and pharmacological consequences of the in vivo deamidation of trastuzumab and pertuzumab

Analytical and bioanalytical chemistry, 2022-02, Vol.414 (4), p.1513-1524

2022

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LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma

Analytical chemistry (Washington), 2016-02, Vol.88 (3), p.1871-1877

2016

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Non-Antibody-Based Binders for the Enrichment of Proteins for Analysis by Mass Spectrometry

Biomolecules (Basel, Switzerland), 2021-11, Vol.11 (12), p.1791

2021

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High-Sensitivity LC-MS/MS Quantification of Peptides and Proteins in Complex Biological Samples: The Impact of Enzymatic Digestion and Internal Standard Selection on Method Performance

Analytical chemistry (Washington), 2013-10, Vol.85 (20), p.9528-9535

2013

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An antibody-free LC-MS/MS method for the quantification of sex hormone binding globulin in human serum and plasma

Clinical chemistry and laboratory medicine, 2023-06, Vol.61 (7), p.1266-1274

2023

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Intact protein bioanalysis by liquid chromatography – High-resolution mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2019-03, Vol.1110-1111, p.155-167

2019

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A fully validated liquid chromatography-mass spectrometry method for the quantification of the soluble receptor of advanced glycation end-products (sRAGE) in serum using immunopurification in a 96-well plate format

Talanta (Oxford), 2018-05, Vol.182, p.414-421

2018

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Very complex internal standard response variation in LC–MS/MS bioanalysis: root cause analysis and impact assessment

Bioanalysis, 2019-09, Vol.11 (18), p.1693-1700

2019

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Quantification of biopharmaceuticals and biomarkers in complex biological matrices: a comparison of liquid chromatography coupled to tandem mass spectrometry and ligand binding assays

Expert review of proteomics, 2015-08, Vol.12 (4), p.355-374

2015

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Quantification of free and total desmosine and isodesmosine in human urine by liquid chromatography tandem mass spectrometry: A comparison of the surrogate-analyte and the surrogate-matrix approach for quantitation

Journal of Chromatography A, 2014-01, Vol.1326, p.13-19

2014

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Effect of Trastuzumab-HER2 Complex Formation on Stress-Induced Modifications in the CDRs of Trastuzumab

Frontiers in chemistry, 2022-01, Vol.9, p.794247-794247

2022

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Analytical tools for the characterization of deamidation in monoclonal antibodies

Journal of Chromatography Open, 2022-11, Vol.2, p.100025, Article 100025

2022

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Antibody-free workflows for protein quantification by LC-MS/MS

Bioanalysis, 2015-04, Vol.7 (6), p.763-779

2015

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Pertuzumab Charge Variant Analysis and Complementarity-Determining Region Stability Assessment to Deamidation

Analytical chemistry (Washington), 2023-02, Vol.95 (8), p.3951-3958

2023

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Internal standards in the quantitative determination of protein biopharmaceuticals using liquid chromatography coupled to mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012-04, Vol.893-894, p.1-14

2012

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Monitoring of the deuterated and nondeuterated forms of levodopa and five metabolites in plasma and urine by LC-MS/MS

Bioanalysis, 2019-02, Vol.11 (4), p.279-293

2019

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Enrichment and Liquid Chromatography–Mass Spectrometry Analysis of Trastuzumab and Pertuzumab Using Affimer Reagents

Analytical chemistry (Washington), 2021-10, Vol.93 (40), p.13597-13605

2021

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Determination of Binding Sites on Trastuzumab and Pertuzumab to Selective Affimers Using Hydrogen–Deuterium Exchange Mass Spectrometry

Journal of the American Society for Mass Spectrometry, 2023-04, Vol.34 (4), p.775-783

2023

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SHBG gene polymorphisms and their influence on serum SHBG, total and free testosterone concentrations in men

The journal of clinical endocrinology and metabolism, 2024-04

2024

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Intact protein quantification in biological samples by liquid chromatography – high-resolution mass spectrometry: somatropin in rat plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020-05, Vol.1144, p.122079-122079, Article 122079

2020

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Revealing charge heterogeneity of stressed trastuzumab at the subunit level

Analytical and bioanalytical chemistry, 2023-03, Vol.415 (8), p.1505-1513

2023

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Quantitative bioanalysis of proteins by digestion and LC–MS/MS: the use of multiple signature peptides

Bioanalysis, 2023-10, Vol.15 (19), p.1203-1216

2023

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Simultaneous quantification of the 22-kDa isoforms of human growth hormone 1 and 2 in human plasma by multiplexed immunocapture and LC-MS/MS

Clinica chimica acta, 2024-02, Vol.554, p.117736-117736, Article 117736

2024

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Selective quantification of the 22-kDa isoform of human growth hormone 1 in serum and plasma by immunocapture and LC–MS/MS

Analytical and bioanalytical chemistry, 2022-08, Vol.414 (20), p.6187-6200

2022

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Protein Quantification by LC–MS: A Decade of Progress Through the Pages of Bioanalysis

Analytical and pharmacological consequences of the in vivo deamidation of trastuzumab and pertuzumab

LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma

Non-Antibody-Based Binders for the Enrichment of Proteins for Analysis by Mass Spectrometry

High-Sensitivity LC-MS/MS Quantification of Peptides and Proteins in Complex Biological Samples: The Impact of Enzymatic Digestion and Internal Standard Selection on Method Performance

An antibody-free LC-MS/MS method for the quantification of sex hormone binding globulin in human serum and plasma

Intact protein bioanalysis by liquid chromatography – High-resolution mass spectrometry

A fully validated liquid chromatography-mass spectrometry method for the quantification of the soluble receptor of advanced glycation end-products (sRAGE) in serum using immunopurification in a 96-well plate format

Very complex internal standard response variation in LC–MS/MS bioanalysis: root cause analysis and impact assessment

Quantification of biopharmaceuticals and biomarkers in complex biological matrices: a comparison of liquid chromatography coupled to tandem mass spectrometry and ligand binding assays

Quantification of free and total desmosine and isodesmosine in human urine by liquid chromatography tandem mass spectrometry: A comparison of the surrogate-analyte and the surrogate-matrix approach for quantitation

Effect of Trastuzumab-HER2 Complex Formation on Stress-Induced Modifications in the CDRs of Trastuzumab

Analytical tools for the characterization of deamidation in monoclonal antibodies

Antibody-free workflows for protein quantification by LC-MS/MS

Pertuzumab Charge Variant Analysis and Complementarity-Determining Region Stability Assessment to Deamidation

Internal standards in the quantitative determination of protein biopharmaceuticals using liquid chromatography coupled to mass spectrometry

Monitoring of the deuterated and nondeuterated forms of levodopa and five metabolites in plasma and urine by LC-MS/MS

Enrichment and Liquid Chromatography–Mass Spectrometry Analysis of Trastuzumab and Pertuzumab Using Affimer Reagents

Determination of Binding Sites on Trastuzumab and Pertuzumab to Selective Affimers Using Hydrogen–Deuterium Exchange Mass Spectrometry

SHBG gene polymorphisms and their influence on serum SHBG, total and free testosterone concentrations in men

Intact protein quantification in biological samples by liquid chromatography – high-resolution mass spectrometry: somatropin in rat plasma

Revealing charge heterogeneity of stressed trastuzumab at the subunit level

Quantitative bioanalysis of proteins by digestion and LC–MS/MS: the use of multiple signature peptides

Simultaneous quantification of the 22-kDa isoforms of human growth hormone 1 and 2 in human plasma by multiplexed immunocapture and LC-MS/MS

Selective quantification of the 22-kDa isoform of human growth hormone 1 in serum and plasma by immunocapture and LC–MS/MS

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