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Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy

Metabolomics, 2017-01, Vol.13 (1), p.9, Article 9

2017

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Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagement

British journal of clinical pharmacology, 2021-12, Vol.87 (12), p.4658-4669

2021

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A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery

Nature communications, 2019-07, Vol.10 (1), p.3118-6, Article 3118

2019

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The power of modelling pulsatile profiles

Journal of pharmacokinetics and pharmacodynamics, 2021-06, Vol.48 (3), p.439-444

2021

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Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers

European journal of clinical pharmacology, 2021-08, Vol.77 (8), p.1181-1192

2021

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Theoretical Performance of Nonlinear Mixed-Effect Models Incorporating Saliva as an Alternative Sampling Matrix for Therapeutic Drug Monitoring in Pediatrics: A Simulation Study

Therapeutic drug monitoring, 2021-08, Vol.43 (4), p.546-554

2021

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Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling

Journal of pharmacokinetics and pharmacodynamics, 2020-06, Vol.47 (3), p.229-239

2020

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Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

Alzheimer's & dementia : translational research & clinical interventions, 2020, Vol.6 (1), p.e12093-n/a

2020

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Dose escalations in phase I studies: Feasibility of interpreting blinded pharmacodynamic data

British journal of clinical pharmacology, 2022-12, Vol.88 (12), p.5412-5419

2022

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First-in-Human Assessment of cRGD-ZW800-1, a Zwitterionic, Integrin-Targeted, Near-Infrared Fluorescent Peptide in Colon Carcinoma

Clinical cancer research, 2020-08, Vol.26 (15), p.3990-3998

2020

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Model informed quantification of the feed‐forward stimulation of growth hormone by growth hormone‐releasing hormone

British journal of clinical pharmacology, 2020-08, Vol.86 (8), p.1575-1584

2020

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Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study

Clinical pharmacology and therapeutics, 2022-11, Vol.112 (5), p.1008-1019

2022

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Impact of enantiomer‐specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis

British journal of clinical pharmacology, 2021-03, Vol.87 (3), p.1443-1454

2021

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Population pharmacokinetics of clonazepam in saliva and plasma: Steps towards noninvasive pharmacokinetic studies in vulnerable populations

British journal of clinical pharmacology, 2022-05, Vol.88 (5), p.2236-2245

2022

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Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial

British journal of clinical pharmacology, 2022-03, Vol.88 (3), p.1054-1062

2022

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A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation

British journal of clinical pharmacology, 2024-04, Vol.90 (4), p.1027-1035

2024

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Comprehensive evaluation of microneedle‐based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial

British journal of clinical pharmacology, 2021-08, Vol.87 (8), p.3162-3176

2021

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Accelerating vaccine trial conduct in a pandemic with a hot spot‐based inclusion strategy using trial and epidemic simulation

Clinical and translational science, 2021-11, Vol.14 (6), p.2391-2398

2021

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Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: An exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis

British journal of clinical pharmacology, 2020-01, Vol.86 (1), p.175-181

2020

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The Oral Pheneticillin Absorption Test: An Accurate Method to Identify Patients with Inadequate Oral Pheneticillin Absorption

Antibiotics (Basel), 2019-08, Vol.8 (3), p.119

2019

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Biperiden Challenge Model in Healthy Elderly as Proof‐of‐Pharmacology Tool: A Randomized, Placebo‐Controlled Trial

Journal of clinical pharmacology, 2021-11, Vol.61 (11), p.1466-1478

2021

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A Novel Somatostatin-Dopamine Chimera (BIM23B065) Reduced GH Secretion in a First-in-Human Clinical Trial

The journal of clinical endocrinology and metabolism, 2019-03, Vol.104 (3), p.883-891

2019

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Item Response Theory in Early Phase Clinical Trials: Utilization of a Reference Model to Analyse the Montgomery-Åsberg Depression Rating Scale (MADRS)

CPT: pharmacometrics and systems pharmacology, 2023-10, Vol.12 (10), p.1425-1436

2023

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How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review

Pituitary, 2018-06, Vol.21 (3), p.310-322

2018

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Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy

Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagement

A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery

The power of modelling pulsatile profiles

Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers

Theoretical Performance of Nonlinear Mixed-Effect Models Incorporating Saliva as an Alternative Sampling Matrix for Therapeutic Drug Monitoring in Pediatrics: A Simulation Study

Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling

Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

Dose escalations in phase I studies: Feasibility of interpreting blinded pharmacodynamic data

First-in-Human Assessment of cRGD-ZW800-1, a Zwitterionic, Integrin-Targeted, Near-Infrared Fluorescent Peptide in Colon Carcinoma

Model informed quantification of the feed‐forward stimulation of growth hormone by growth hormone‐releasing hormone

Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study

Impact of enantiomer‐specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis

Population pharmacokinetics of clonazepam in saliva and plasma: Steps towards noninvasive pharmacokinetic studies in vulnerable populations

Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial

A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation

Comprehensive evaluation of microneedle‐based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial

Accelerating vaccine trial conduct in a pandemic with a hot spot‐based inclusion strategy using trial and epidemic simulation

Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: An exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis

The Oral Pheneticillin Absorption Test: An Accurate Method to Identify Patients with Inadequate Oral Pheneticillin Absorption

Biperiden Challenge Model in Healthy Elderly as Proof‐of‐Pharmacology Tool: A Randomized, Placebo‐Controlled Trial

A Novel Somatostatin-Dopamine Chimera (BIM23B065) Reduced GH Secretion in a First-in-Human Clinical Trial

Item Response Theory in Early Phase Clinical Trials: Utilization of a Reference Model to Analyse the Montgomery-Åsberg Depression Rating Scale (MADRS)

How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review

Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial

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