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Transgenic animal models in toxicology: historical perspectives and future outlook

Toxicological sciences, 2011-06, Vol.121 (2), p.207-233

2011

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Strategies in genotoxicology: Acceptance of innovative scientific methods in a regulatory context and from an industrial perspective

Mutation research. Genetic toxicology and environmental mutagenesis, 2020-05, Vol.853, p.503171, Article 503171

2020

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Hazardous compounds in tobacco smoke

International journal of environmental research and public health, 2011-02, Vol.8 (2), p.613-628

2011

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Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data

Environmental and molecular mutagenesis, 2023-01, Vol.64 (1), p.4-15

2023

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Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment

Environmental and molecular mutagenesis, 2024-01, Vol.65 (1-2), p.4-24

2024

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Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

Mutation research, 2009-09, Vol.682 (2), p.94-109

2009

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Application of the adverse outcome pathway framework to genotoxic modes of action

Environmental and molecular mutagenesis, 2020-01, Vol.61 (1), p.114-134

2020

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In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing?

Environmental and molecular mutagenesis, 2020-01, Vol.61 (1), p.55-65

2020

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Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review

Environmental and molecular mutagenesis, 2022-12, Vol.63 (8-9), p.376-388

2022

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Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene

Environmental and molecular mutagenesis, 2020-01, Vol.61 (1), p.94-113

2020

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Main issues addressed in the 2014–2015 revisions to the OECD Genetic Toxicology Test Guidelines

Environmental and molecular mutagenesis, 2017-06, Vol.58 (5), p.284-295

2017

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Approaches for identifying germ cell mutagens: Report of the 2013 IWGT workshop on germ cell assays

Mutation research. Genetic toxicology and environmental mutagenesis, 2015-05, Vol.783, p.36-54

2015

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A mode-of-action approach for the identification of genotoxic carcinogens

PloS one, 2013-05, Vol.8 (5), p.e64532

2013

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ECVAM retrospective validation of in vitro micronucleus test (MNT)

Mutagenesis, 2008-07, Vol.23 (4), p.271-283

2008

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Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488

Mutation research. Genetic toxicology and environmental mutagenesis, 2018-08, Vol.832-833, p.19-28

2018

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Clarification of some aspects related to genotoxicity assessment

EFSA journal, 2017-12, Vol.15 (12), p.e05113-n/a

2017

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Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data

Regulatory toxicology and pharmacology, 2016-11, Vol.81, p.242-249

2016

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Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells

BMC genomics, 2010-01, Vol.11 (1), p.24-24, Article 24

2010

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Differential Contributions of Mammalian Rad54 Paralogs to Recombination, DNA Damage Repair, and Meiosis

Molecular and Cellular Biology, 2006-02, Vol.26 (3), p.976-989

2006

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Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop

Mutation research, 2009-11, Vol.680 (1), p.31-42

2009

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Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells

Toxicological sciences, 2011-01, Vol.119 (1), p.218-223

2011

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Detection of genotoxic and non-genotoxic carcinogens in Xpc−/−p53+/− mice

Toxicology and applied pharmacology, 2013-01, Vol.266 (2), p.289-297

2013

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Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro

Environmental and molecular mutagenesis, 2012-06, Vol.53 (5), p.376-383

2012

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Strategies in case of positive in vivo results in genotoxicity testing

Mutation research, 2011-08, Vol.723 (2), p.121-128

2011

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Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests

Mutation research. Genetic toxicology and environmental mutagenesis, 2016-01, Vol.795, p.7-30

2016

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Transgenic animal models in toxicology: historical perspectives and future outlook

Strategies in genotoxicology: Acceptance of innovative scientific methods in a regulatory context and from an industrial perspective

Hazardous compounds in tobacco smoke

Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data

Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

Application of the adverse outcome pathway framework to genotoxic modes of action

In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing?

Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review

Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene

Main issues addressed in the 2014–2015 revisions to the OECD Genetic Toxicology Test Guidelines

Approaches for identifying germ cell mutagens: Report of the 2013 IWGT workshop on germ cell assays

A mode-of-action approach for the identification of genotoxic carcinogens

ECVAM retrospective validation of in vitro micronucleus test (MNT)

Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488

Clarification of some aspects related to genotoxicity assessment

Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data

Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells

Differential Contributions of Mammalian Rad54 Paralogs to Recombination, DNA Damage Repair, and Meiosis

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop

Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells

Detection of genotoxic and non-genotoxic carcinogens in Xpc−/−p53+/− mice

Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro

Strategies in case of positive in vivo results in genotoxicity testing

Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests

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