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Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment

Environment international, 2019-07, Vol.128, p.417-429

2019

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Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach methodologies

Archives of toxicology, 2021-06, Vol.95 (6), p.1867-1897

2021

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Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

Archives of toxicology, 2020-08, Vol.94 (8), p.2899-2923

2020

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Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment

Archives of toxicology, 2021-06, Vol.95 (6), p.1971-1993

2021

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Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy

Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (24), p.8215-8220

2008

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Analyses of Transcriptomics Cell Signalling for Pre-Screening Applications in the Integrated Approach for Testing and Assessment of Non-Genotoxic Carcinogens

International journal of molecular sciences, 2022-11, Vol.23 (21), p.12718

2022

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Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index

Cancer research (Chicago, Ill.), 2010-02, Vol.70 (4), p.1564-1572

2010

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In vitro genotoxicity testing–Can the performance be enhanced?

Food and chemical toxicology, 2017-08, Vol.106 (Pt B), p.600-608

2017

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Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals

Critical reviews in toxicology, 2020-10, Vol.50 (9), p.725-739

2020

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Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension

PLoS genetics, 2009-05, Vol.5 (5), p.e1000467-e1000467

2009

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A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals

Regulatory toxicology and pharmacology, 2020-12, Vol.118, p.104789, Article 104789

2020

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Making better use of toxicity studies for human health by extrapolating across endpoints_suppl

ALTEX, alternatives to animal experimentation, 2020

Madia, Federica

2020

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Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system

The Journal of cell biology, 2008-01, Vol.180 (1), p.67-81

2008

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Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells

Toxicology letters, 2004-12, Vol.154 (1), p.11-21

2004

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Early Developmental Exposure to BDE 99 or Aroclor 1254 Affects Neurobehavioural Profile: Interference from the Administration Route

Neurotoxicology (Park Forest South), 2005-03, Vol.26 (2), p.183-192

2005

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EURL ECVAM Genotoxicity and Carcinogenicity Database of Substances Eliciting Negative Results in the Ames Test: Construction of the Database

Mutation research, 2020-06, Vol.854-855, p.503199, Article 503199

2020

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Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests

Mutation research. Genetic toxicology and environmental mutagenesis, 2016-01, Vol.795, p.7-30

2016

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Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

Cell metabolism, 2014-03, Vol.19 (3), p.407-417

2014

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Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

Science translational medicine, 2011-02, Vol.3 (70), p.70ra13

2011

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Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? II. Construction and analysis of a consolidated database

Mutation research. Genetic toxicology and environmental mutagenesis, 2014-12, Vol.775-776, p.69-80

2014

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Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Environmental health perspectives, 2023-10, Vol.131 (10), p.105001-105001

2023

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Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

Toxicology in vitro, 2017-12, Vol.45 (Pt 3), p.278-286

2017

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Corrigendum to “EURL ECVAM genotoxicity and carcinogenicity database of substances eliciting negative results in the Ames test: Construction of the database” [Mutat. Res. 854–855 June–July (2020) 503199]

Mutation research. Genetic toxicology and environmental mutagenesis, 2020-10, Vol.858-860, p.503274, Article 503274

2020

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Carcinogenicity of occupational exposure as a firefighter

The lancet oncology, 2022-08, Vol.23 (8), p.985-986

2022

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Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop

Regulatory toxicology and pharmacology, 2022-11, Vol.135, p.105261-105261, Article 105261

2022

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Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment

Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach methodologies

Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy

Analyses of Transcriptomics Cell Signalling for Pre-Screening Applications in the Integrated Approach for Testing and Assessment of Non-Genotoxic Carcinogens

Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index

In vitro genotoxicity testing–Can the performance be enhanced?

Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals

Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension

A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals

Making better use of toxicity studies for human health by extrapolating across endpoints_suppl

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system

Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells

Early Developmental Exposure to BDE 99 or Aroclor 1254 Affects Neurobehavioural Profile: Interference from the Administration Route

EURL ECVAM Genotoxicity and Carcinogenicity Database of Substances Eliciting Negative Results in the Ames Test: Construction of the Database

Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? II. Construction and analysis of a consolidated database

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

Corrigendum to “EURL ECVAM genotoxicity and carcinogenicity database of substances eliciting negative results in the Ames test: Construction of the database” [Mutat. Res. 854–855 June–July (2020) 503199]

Carcinogenicity of occupational exposure as a firefighter

Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop

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