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CRISPR/Cas9 Mediated KO Studies Identified Essential Genes for Fertilization and Oocyte Activation

Fertility & reproduction, 2023-12, Vol.5 (4), p.295-295

Ikawa, Masahito

2023

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Eukaryotic fertilization and gamete fusion at a glance

Journal of cell science, 2022-11, Vol.135 (22)

2022

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Adhesion G protein-coupled receptor G2 is dispensable for lumicrine signaling regulating epididymal initial segment differentiation and gene expression

Biology of reproduction, 2023-10, Vol.109 (4), p.474-481

2023

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Structural insights into tetraspanin CD9 function

Nature communications, 2020-03, Vol.11 (1), p.1606-1606, Article 1606

2020

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GPI-AP release in cellular, developmental, and reproductive biology

Journal of lipid research, 2016-04, Vol.57 (4), p.538-545

2016

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MiR-200b and miR-429 Function in Mouse Ovulation and Are Essential for Female Fertility

Science (American Association for the Advancement of Science), 2013-07, Vol.341 (6141), p.71-73

2013

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Engineered CRISPR-Cas9 nuclease with expanded targeting space

Science (American Association for the Advancement of Science), 2018-09, Vol.361 (6408), p.1259-1262

2018

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Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA

Scientific reports, 2013-11, Vol.3 (1), p.3355, Article 3355

2013

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Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1

Journal of cell science, 2012-11, Vol.125 (Pt 21), p.4985-4990

2012

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An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility

Journal of Reproduction and Development, 2019, Vol.65(2), pp.121-128

2019

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Astrocytic cAMP modulates memory via synaptic plasticity

Proceedings of the National Academy of Sciences - PNAS, 2021-01, Vol.118 (3), p.1-10

2021

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Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis

Journal of Reproduction and Development, 2019, Vol.65(2), pp.155-162

2019

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Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice

PLoS genetics, 2020-01, Vol.16 (1), p.e1008585-e1008585

2020

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TESMIN, METALLOTHIONEIN-LIKE 5, is Required for Spermatogenesis in Mice

Biology of reproduction, 2020-04, Vol.102 (4), p.975-983

2020

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ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (6), p.1-12

2021

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Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice

PLoS genetics, 2022-06, Vol.18 (6), p.e1010241

2022

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Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis

Nature communications, 2021-06, Vol.12 (1), p.3386-3386, Article 3386

2021

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Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility

American journal of human genetics, 2020-08, Vol.107 (2), p.330-341

2020

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CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy

Clinical cancer research, 2019-03, Vol.25 (6), p.1936-1947

2019

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FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice

Development (Cambridge), 2021-11, Vol.148 (21)

2021

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Physiological function of seminal vesicle secretions on male fecundity

Reproductive medicine and biology, 2019-07, Vol.18 (3), p.241-246

2019

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Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

eLife, 2024-03, Vol.12

2024

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Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

Proceedings of the National Academy of Sciences - PNAS, 2011-01, Vol.108 (4), p.1451-1455

2011

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Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension

The American journal of pathology, 2018-11, Vol.188 (11), p.2474-2486

2018

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Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads

PLoS genetics, 2024-06, Vol.20 (6), p.e1011337

2024

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CRISPR/Cas9 Mediated KO Studies Identified Essential Genes for Fertilization and Oocyte Activation

Eukaryotic fertilization and gamete fusion at a glance

Adhesion G protein-coupled receptor G2 is dispensable for lumicrine signaling regulating epididymal initial segment differentiation and gene expression

Structural insights into tetraspanin CD9 function

GPI-AP release in cellular, developmental, and reproductive biology

MiR-200b and miR-429 Function in Mouse Ovulation and Are Essential for Female Fertility

Engineered CRISPR-Cas9 nuclease with expanded targeting space

Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA

Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1

An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility

Astrocytic cAMP modulates memory via synaptic plasticity

Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis

Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice

TESMIN, METALLOTHIONEIN-LIKE 5, is Required for Spermatogenesis in Mice

ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility

Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice

Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis

Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility

CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy

FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice

Physiological function of seminal vesicle secretions on male fecundity

Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension

Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads

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