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Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Molecular pharmaceutics, 2019-07, Vol.16 (7), p.3261-3274

2019

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Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches

Second edition., 2022

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In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant

Trends in pharmacological sciences (Regular ed.), 2016-10, Vol.37 (10), p.831-842

2016

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Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model

Neurobiology of disease, 2022-07, Vol.169, p.105741-105741, Article 105741

2022

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The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions

Pharmaceutical research, 2020-07, Vol.37 (7), p.137, Article 137

2020

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Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

Trends in pharmacological sciences (Regular ed.), 2008-04, Vol.29 (4), p.186-191

2008

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Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals

International journal of molecular sciences, 2020-04, Vol.21 (9), p.3158

2020

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Effects of daily L-dopa administration on learning and brain structure in older adults undergoing cognitive training: a randomised clinical trial

Scientific reports, 2020-03, Vol.10 (1), p.5227, Article 5227

2020

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High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: Application to pharmacokinetic/pharmacodynamic studies in rats

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-08, Vol.822 (1), p.230-237

2005

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Prediction of methotrexate CNS distribution in different species – Influence of disease conditions

European journal of pharmaceutical sciences, 2014-06, Vol.57, p.11-24

2014

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P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice

Epilepsy & behavior, 2002-10, Vol.3 (5), p.427-432

2002

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T lymphocytes impair P-glycoprotein function during neuroinflammation

Journal of autoimmunity, 2010-06, Vol.34 (4), p.416-425

2010

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Methodological issues in microdialysis sampling for pharmacokinetic studies

Advanced drug delivery reviews, 2000-12, Vol.45 (2), p.125-148

2000

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Understanding Drug Delivery to the Brain Using Liposome-Based Strategies: Studies that Provide Mechanistic Insights Are Essential

The AAPS journal, 2021-10, Vol.23 (6), p.114, Article 114

2021

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Blood‐Based Biomarkers of Quinpirole Pharmacology: Cluster‐Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain

CPT: pharmacometrics and systems pharmacology, 2019-02, Vol.8 (2), p.107-117

2019

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Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring

International journal of molecular sciences, 2021-02, Vol.22 (4), p.2110

2021

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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

The Journal of clinical investigation, 2000-02, Vol.105 (3), p.279-285

2000

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Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

Fluids and barriers of the CNS, 2012-02, Vol.9 (1), p.4-4, Article 4

2012

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Understanding the Blood‐Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

Clinical pharmacology and therapeutics, 2022-04, Vol.111 (4), p.758-773

2022

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The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments

Journal of pharmacological and toxicological methods, 2008-03, Vol.57 (2), p.114-130

2008

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Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference?

European journal of pharmaceutics and biopharmaceutics, 2019-06, Vol.139, p.197-204

2019

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The need for mathematical modelling of spatial drug distribution within the brain

Fluids and barriers of the CNS, 2019-05, Vol.16 (1), p.12-33, Article 12

2019

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CNS Viral Infections—What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches

CNS drugs, 2024-05, Vol.38 (5), p.349-373

2024

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Status of Metabolomic Measurement for Insights in Alzheimer's Disease Progression-What Is Missing?

International journal of molecular sciences, 2023-03, Vol.24 (5), p.4960

2023

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Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology

Journal of Alzheimer's disease, 2022-01, Vol.87 (1), p.51

2022

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Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches

In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant

Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model

The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals

Effects of daily L-dopa administration on learning and brain structure in older adults undergoing cognitive training: a randomised clinical trial

High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: Application to pharmacokinetic/pharmacodynamic studies in rats

Prediction of methotrexate CNS distribution in different species – Influence of disease conditions

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice

T lymphocytes impair P-glycoprotein function during neuroinflammation

Methodological issues in microdialysis sampling for pharmacokinetic studies

Understanding Drug Delivery to the Brain Using Liposome-Based Strategies: Studies that Provide Mechanistic Insights Are Essential

Blood‐Based Biomarkers of Quinpirole Pharmacology: Cluster‐Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain

Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

Understanding the Blood‐Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments

Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference?

The need for mathematical modelling of spatial drug distribution within the brain

CNS Viral Infections—What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches

Status of Metabolomic Measurement for Insights in Alzheimer's Disease Progression-What Is Missing?

Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology

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