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Improving the Prediction of Local Drug Distribution Profiles in the Brain with a New 2D Mathematical Model

Bulletin of mathematical biology, 2019-09, Vol.81 (9), p.3477-3507

2019

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Population pharmacokinetic modelling of non‐linear brain distribution of morphine: influence of active saturable influx and P‐glycoprotein mediated efflux

British journal of pharmacology, 2007-07, Vol.151 (5), p.701-712

2007

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Influence of biophase distribution and P‐glycoprotein interaction on pharmacokinetic‐pharmacodynamic modelling of the effects of morphine on the EEG

British journal of pharmacology, 2007-07, Vol.151 (5), p.713-720

2007

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Translational aspects of blood-brain barrier transport and central nervous system effects of drugs: From discovery to patients

Clinical pharmacology and therapeutics, 2015-04, Vol.97 (4), p.380-394

2015

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P-glycoprotein protein expression versus functionality at the blood-brain barrier using immunohistochemistry, microdialysis and mathematical modeling

European journal of pharmaceutical sciences, 2018-11, Vol.124, p.61-70

2018

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The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.S83-S89

2017

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Application of ED-optimality to screening experiments for analgesic compounds in an experimental model of neuropathic pain

Journal of pharmacokinetics and pharmacodynamics, 2012-12, Vol.39 (6), p.673-681

2012

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Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.431-440

2017

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Analgosedation in paediatric severe traumatic brain injury (TBI): practice, pitfalls and possibilities

Child's nervous system, 2017-10, Vol.33 (10), p.1703-1710

2017

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Effect of altered AGP plasma binding on heart rate changes by S(−)‐propranolol in rats using mechanism‐based estimations of in vivo receptor affinity (KB,vivo)

Journal of pharmaceutical sciences, 2010-05, Vol.99 (5), p.2511-2520

2010

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Influence of Plasma Protein Binding on Pharmacodynamics: Estimation of In Vivo Receptor Affinities of β Blockers Using a New Mechanism-Based PK–PD Modelling Approach

Journal of pharmaceutical sciences, 2009-10, Vol.98 (10), p.3816-3828

2009

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Pharmacokinetic‐pharmacodynamic modelling of S(−)‐atenolol in rats: reduction of isoprenaline‐induced tachycardia as a continuous pharmacodynamic endpoint

British journal of pharmacology, 2007-06, Vol.151 (3), p.356-366

2007

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Bundling arrows: improving translational CNS drug development by integrated PK/PD-metabolomics

Expert opinion on drug discovery, 2018-06, Vol.13 (6), p.539-550

2018

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Multidrug Resistance P-Glycoprotein Hampers the Access of Cortisol But Not of Corticosterone to Mouse and Human Brain

Endocrinology (Philadelphia), 2001-06, Vol.142 (6), p.2686-2694

2001

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Adaptation of a non-ruminant nutrient-based growth model to rainbow trout (Oncorhynchus mykiss Walbaum)

The Journal of agricultural science, 2010-02, Vol.148 (1), p.17-29

2010

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The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone

Journal of endocrinology, 2002-10, Vol.175 (1), p.251-260

2002

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Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

European journal of pharmaceutical sciences, 2023-08, Vol.187, p.106482-106482, Article 106482

2023

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Antituberculosis drug-induced hepatotoxicity: Concise up-to-date review

Journal of gastroenterology and hepatology, 2008-02, Vol.23 (2), p.192-202

2008

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Online solid phase extraction with liquid chromatography–tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010-04, Vol.878 (13), p.969-975

2010

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Clinical relevance of non-tuberculous mycobacteria isolated in the Nijmegen-Arnhem region, The Netherlands

Thorax, 2009-06, Vol.64 (6), p.502-506

2009

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High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: Application to pharmacokinetic/pharmacodynamic studies in rats

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-08, Vol.822 (1), p.230-237

2005

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Mechanism-based pharmacokinetic -pharmacodynamic modeling : Biophase distribution, receptor theory, and dynamical systems analysis

Annual review of pharmacology and toxicology, 2007-01, Vol.47 (1), p.357-400

2007

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Preclinical Prediction of Human Brain Target Site Concentrations: Considerations in Extrapolating to the Clinical Setting

Journal of pharmaceutical sciences, 2011-09, Vol.100 (9), p.3577-3593

2011

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Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients

The European respiratory journal, 2013-12, Vol.42 (6), p.1614-1621

2013

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Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis

The European respiratory journal, 2014-03, Vol.43 (3), p.884-897

2014

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Improving the Prediction of Local Drug Distribution Profiles in the Brain with a New 2D Mathematical Model

Population pharmacokinetic modelling of non‐linear brain distribution of morphine: influence of active saturable influx and P‐glycoprotein mediated efflux

Influence of biophase distribution and P‐glycoprotein interaction on pharmacokinetic‐pharmacodynamic modelling of the effects of morphine on the EEG

Translational aspects of blood-brain barrier transport and central nervous system effects of drugs: From discovery to patients

P-glycoprotein protein expression versus functionality at the blood-brain barrier using immunohistochemistry, microdialysis and mathematical modeling

The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation

Application of ED-optimality to screening experiments for analgesic compounds in an experimental model of neuropathic pain

Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats

Analgosedation in paediatric severe traumatic brain injury (TBI): practice, pitfalls and possibilities

Effect of altered AGP plasma binding on heart rate changes by S(−)‐propranolol in rats using mechanism‐based estimations of in vivo receptor affinity (KB,vivo)

Influence of Plasma Protein Binding on Pharmacodynamics: Estimation of In Vivo Receptor Affinities of β Blockers Using a New Mechanism-Based PK–PD Modelling Approach

Pharmacokinetic‐pharmacodynamic modelling of S(−)‐atenolol in rats: reduction of isoprenaline‐induced tachycardia as a continuous pharmacodynamic endpoint

Bundling arrows: improving translational CNS drug development by integrated PK/PD-metabolomics

Multidrug Resistance P-Glycoprotein Hampers the Access of Cortisol But Not of Corticosterone to Mouse and Human Brain

Adaptation of a non-ruminant nutrient-based growth model to rainbow trout (Oncorhynchus mykiss Walbaum)

The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

Antituberculosis drug-induced hepatotoxicity: Concise up-to-date review

Online solid phase extraction with liquid chromatography–tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples

Clinical relevance of non-tuberculous mycobacteria isolated in the Nijmegen-Arnhem region, The Netherlands

High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: Application to pharmacokinetic/pharmacodynamic studies in rats

Mechanism-based pharmacokinetic -pharmacodynamic modeling : Biophase distribution, receptor theory, and dynamical systems analysis

Preclinical Prediction of Human Brain Target Site Concentrations: Considerations in Extrapolating to the Clinical Setting

Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients

Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis

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