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The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?

Genes, 2019-03, Vol.10 (3), p.208

de Cárcer, Guillermo

2019

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From Plk1 to Plk5: Functional evolution of polo-like kinases

Cell cycle (Georgetown, Tex.), 2011-07, Vol.10 (14), p.2255-2262

2011

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Plk1 overexpression induces chromosomal instability and suppresses tumor development

Nature communications, 2018-08, Vol.9 (1), p.3012-14, Article 3012

2018

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Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest

ACS nano, 2013-09, Vol.7 (9), p.7483-7494

2013

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Lights and Shadows on the Cancer Multi-Target Inhibitor Rigosertib (ON-01910.Na)

Pharmaceutics, 2023-04, Vol.15 (4), p.1232

2023

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HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

Molecular cell, 2012-12, Vol.48 (5), p.681-691

2012

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PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models

The Journal of clinical investigation, 2023-11, Vol.133 (21), p.1-16

2023

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Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis

Nature medicine, 2017-08, Vol.23 (8), p.964-974

2017

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Overcoming PLK1 inhibitor resistance by targeting mevalonate pathway to impair AXL-TWIST axis in colorectal cancer

Biomedicine & pharmacotherapy, 2021-12, Vol.144, p.112347-112347, Article 112347

2021

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Aurora A drives early signalling and vesicle dynamics during T-cell activation

Nature communications, 2016-04, Vol.7 (1), p.11389-11389, Article 11389

2016

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Targeting cell cycle kinases for cancer therapy

Current medicinal chemistry, 2007-04, Vol.14 (9), p.969-985

2007

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Whole-Genome Doubling as a source of cancer: how, when, where, and why?

Frontiers in cell and developmental biology, 2023-06, Vol.11, p.1209136-1209136

2023

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TRF1 Controls Telomere Length and Mitotic Fidelity in Epithelial Homeostasis

Molecular and Cellular Biology, 2009-03, Vol.29 (6), p.1608-1625

2009

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Heat shock protein 90 regulates the metaphase-anaphase transition in a polo-like kinase-dependent manner

Cancer research (Chicago, Ill.), 2004-08, Vol.64 (15), p.5106-5112

DE CARCER, Guillermo

2004

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Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia

Frontiers in oncology, 2021-11, Vol.11, p.752933-752933

2021

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Squamous differentiation requires G2/mitosis slippage to avoid apoptosis

Cell death and differentiation, 2020-08, Vol.27 (8), p.2451-2467

2020

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A centrosomal route for cancer genome instability

Nature cell biology, 2014-06, Vol.16 (6), p.504-506

2014

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A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

Carcinogenesis (New York), 2007-05, Vol.28 (5), p.899-912

2007

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Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies

BioEssays, 2016-07, Vol.38 (S1), p.S96-S106

2016

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A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells

Cell reports (Cambridge), 2019-07, Vol.28 (3), p.597-604.e4

2019

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Plk5, a Polo Box Domain-Only Protein with Specific Roles in Neuron Differentiation and Glioblastoma Suppression

Molecular and Cellular Biology, 2011-03, Vol.31 (6), p.1225-1239

2011

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Chromosome instability: From molecular mechanisms to disease

DNA repair, 2018-06, Vol.66-67, p.72-75

2018

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The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells

Gut, 2024-09, Vol.73 (9), p.1489-1508

2024

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TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signaling

Molecular oncology, 2024-06, Vol.18 (6), p.1531-1551

2024

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Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice

Blood, 2015-10, Vol.126 (14), p.1707-1714

2015

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The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?

From Plk1 to Plk5: Functional evolution of polo-like kinases

Plk1 overexpression induces chromosomal instability and suppresses tumor development

Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest

Lights and Shadows on the Cancer Multi-Target Inhibitor Rigosertib (ON-01910.Na)

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis

Overcoming PLK1 inhibitor resistance by targeting mevalonate pathway to impair AXL-TWIST axis in colorectal cancer

Aurora A drives early signalling and vesicle dynamics during T-cell activation

Targeting cell cycle kinases for cancer therapy

Whole-Genome Doubling as a source of cancer: how, when, where, and why?

TRF1 Controls Telomere Length and Mitotic Fidelity in Epithelial Homeostasis

Heat shock protein 90 regulates the metaphase-anaphase transition in a polo-like kinase-dependent manner

Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia

Squamous differentiation requires G2/mitosis slippage to avoid apoptosis

A centrosomal route for cancer genome instability

A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies

A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells

Plk5, a Polo Box Domain-Only Protein with Specific Roles in Neuron Differentiation and Glioblastoma Suppression

Chromosome instability: From molecular mechanisms to disease

The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells

TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signaling

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice

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