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A fresh look at an old problem

The Lancet infectious diseases, 2017-12, Vol.17 (12), p.1228-1230

Zydowsky, Thomas M

2017

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Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

Nature communications, 2018-09, Vol.9 (1), p.3881-9, Article 3881

2018

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Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus

Antimicrobial agents and chemotherapy, 2015-12, Vol.59 (12), p.7290-7298

2015

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Taking the daily grind out of HIV prevention

EBioMedicine, 2020-09, Vol.59, p.102934-102934, Article 102934

Zydowsky, Thomas M.

2020

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Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model

Marine drugs, 2021-07, Vol.19 (8), p.418

2021

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A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV

PloS one, 2014-04, Vol.9 (4), p.e94547

2014

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An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques

PloS one, 2011-01, Vol.6 (1), p.e15835

2011

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A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy

Journal of controlled release, 2015-09, Vol.213, p.57-68

2015

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A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo

PloS one, 2016-07, Vol.11 (7), p.e0159332-e0159332

2016

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Preclinical assessments of vaginal microbicide candidate safety and efficacy

Advanced drug delivery reviews, 2015-09, Vol.92, p.27-38

2015

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A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy

PloS one, 2009-11, Vol.4 (11), p.e8060-e8060

2009

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First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics

Journal of acquired immune deficiency syndromes (1999), 2016-12, Vol.73 (5), p.489-496

2016

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Zinc Acetate/Carrageenan Gels Exhibit Potent Activity In Vivo against High-Dose Herpes Simplex Virus 2 Vaginal and Rectal Challenge

Antimicrobial Agents and Chemotherapy, 2012, Vol.56 (1), p.358-368

2012

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A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants

PloS one, 2014-09, Vol.9 (9), p.e108109

2014

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Antiviral activity of aframomum melegueta against severe acute respiratory syndrome coronaviruses type 1 and 2

South African journal of botany, 2022-05, Vol.146, p.735-739

2022

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A Modified Zinc Acetate Gel, a Potential Nonantiretroviral Microbicide, Is Safe and Effective against Simian-Human Immunodeficiency Virus and Herpes Simplex Virus 2 Infection In Vivo

Antimicrobial Agents and Chemotherapy, 2013-08, Vol.57 (8), p.4001-4009

2013

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An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques

Science translational medicine, 2012-09, Vol.4 (150), p.150ra123

2012

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MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa

Journal of acquired immune deficiency syndromes (1999), 2017-03, Vol.74 (3), p.e67-e74

2017

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In Vitro Exposure to PC-1005 and Cervicovaginal Lavage Fluid from Women Vaginally Administered PC-1005 Inhibits HIV-1 and HSV-2 Infection in Human Cervical Mucosa

Antimicrobial agents and chemotherapy, 2016-09, Vol.60 (9), p.5459-5466

2016

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A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

PLoS pathogens, 2016-06, Vol.12 (6), p.e1005720

2016

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MIV-150/zinc acetate gel inhibits cell-associated simian-human immunodeficiency virus reverse transcriptase infection in a macaque vaginal explant model

Antimicrobial agents and chemotherapy, 2015-07, Vol.59 (7), p.3829-3837

2015

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MIV-150-Containing Intravaginal Rings Protect Macaque Vaginal Explants against SHIV-RT Infection

Antimicrobial agents and chemotherapy, 2014-05, Vol.58 (5), p.2841-2848

2014

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Topical formulations to prevent sexually transmitted infections: are we on track?

Future virology, 2019-08, Vol.14 (8), p.503-506

2019

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Results of a phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel

A fresh look at an old problem

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus

Taking the daily grind out of HIV prevention

Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model

A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV

An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques

A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy

A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo

Preclinical assessments of vaginal microbicide candidate safety and efficacy

A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy

First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics

Zinc Acetate/Carrageenan Gels Exhibit Potent Activity In Vivo against High-Dose Herpes Simplex Virus 2 Vaginal and Rectal Challenge

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques

A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants

Antiviral activity of aframomum melegueta against severe acute respiratory syndrome coronaviruses type 1 and 2

A Modified Zinc Acetate Gel, a Potential Nonantiretroviral Microbicide, Is Safe and Effective against Simian-Human Immunodeficiency Virus and Herpes Simplex Virus 2 Infection In Vivo

An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques

MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa

In Vitro Exposure to PC-1005 and Cervicovaginal Lavage Fluid from Women Vaginally Administered PC-1005 Inhibits HIV-1 and HSV-2 Infection in Human Cervical Mucosa

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

MIV-150/zinc acetate gel inhibits cell-associated simian-human immunodeficiency virus reverse transcriptase infection in a macaque vaginal explant model

MIV-150-Containing Intravaginal Rings Protect Macaque Vaginal Explants against SHIV-RT Infection

Topical formulations to prevent sexually transmitted infections: are we on track?

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