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The shedding protease ADAM17: Physiology and pathophysiology

Biochimica et biophysica acta. Molecular cell research, 2017-11, Vol.1864 (11), p.2059-2070

2017

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α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (7), p.1931-1936

2016

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Modeling neuronopathic storage diseases with patient-derived culture systems

Neurobiology of disease, 2019-07, Vol.127, p.147-162

2019

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ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling

The Journal of experimental medicine, 2018-04, Vol.215 (4), p.1205-1225

2018

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The role of lysosomes in alpha-synucleinopathies: a focus on glial cells

Neural regeneration research, 2022-07, Vol.17 (7), p.1486-1488

2022

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Molecular dynamics simulations of the delta and omicron SARS-CoV-2 spike – ACE2 complexes reveal distinct changes between both variants

Computational and structural biotechnology journal, 2022-01, Vol.20, p.1168-1176

2022

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The hexosamine biosynthetic pathway rescues lysosomal dysfunction in Parkinson's disease patient iPSC derived midbrain neurons

Nature communications, 2024-06, Vol.15 (1), p.5206-17, Article 5206

2024

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Therapeutic potential of lysosomal cathepsins for neurodegenerative diseases

Neural regeneration research, 2023-08, Vol.18 (8), p.1713-1714

2023

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LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (43), p.15573-15578

2014

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Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) is localized in lysosomes and mediates resistance against kinase inhibitors

Molecular pharmacology, 2022-12, Vol.102 (6), p.248-258

2022

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Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells

International journal of molecular sciences, 2022-02, Vol.23 (3), p.1812

2022

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Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide

Biomedicines, 2021-05, Vol.9 (5), p.525

2021

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Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties

Frontiers in cell and developmental biology, 2021-02, Vol.9, p.581805-581805

2021

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Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (14), p.3791-3796

2016

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Alpha Synuclein Connects the Gut-Brain Axis in Parkinson’s Disease Patients – A View on Clinical Aspects, Cellular Pathology and Analytical Methodology

Frontiers in cell and developmental biology, 2020-09, Vol.8, p.573696-573696

2020

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Functional Characterization of Colon Cancer-Associated Mutations in ADAM17 : Modifications in the Pro-Domain Interfere with Trafficking and Maturation

International journal of molecular sciences, 2019-05, Vol.20 (9), p.2198

2019

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Editorial: Intracellular Mechanisms of α-Synuclein Processing

Frontiers in cell and developmental biology, 2021-09, Vol.9, p.752378-752378

2021

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The Quest for Anti-α-Synuclein Antibody Specificity-Lessons Learnt From Flow Cytometry Analysis

Frontiers in neurology, 2022-07, Vol.13, p.869103

2022

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LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease

Acta neuropathologica communications, 2015-01, Vol.3 (1), p.6-6, Article 6

2015

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Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models

Translational neurodegeneration, 2023-06, Vol.12 (1), p.31-31, Article 31

2023

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Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson's Disease

Frontiers in medicine, 2021-07, Vol.8, p.655123-655123

2021

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Activation and Purification of ß‐Glucocerebrosidase by Exploiting its Transporter LIMP‐2 – Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease

Advanced science, 2024-07, Vol.11 (25), p.e2401641-n/a

2024

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Late‐onset Krabbe disease presenting as spastic paraplegia – implications of GCase and CTSB/D

Annals of clinical and translational neurology, 2024-07, Vol.11 (7), p.1715-1731

2024

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Proteolysis of CD44 at the cell surface controls a downstream protease network

Frontiers in molecular biosciences, 2023-02, Vol.10, p.1026810-1026810

2023

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Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries

British journal of pharmacology, 2012-06, Vol.166 (4), p.1377-1387

2012

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The shedding protease ADAM17: Physiology and pathophysiology

α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

Modeling neuronopathic storage diseases with patient-derived culture systems

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling

The role of lysosomes in alpha-synucleinopathies: a focus on glial cells

Molecular dynamics simulations of the delta and omicron SARS-CoV-2 spike – ACE2 complexes reveal distinct changes between both variants

The hexosamine biosynthetic pathway rescues lysosomal dysfunction in Parkinson's disease patient iPSC derived midbrain neurons

Therapeutic potential of lysosomal cathepsins for neurodegenerative diseases

LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) is localized in lysosomes and mediates resistance against kinase inhibitors

Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells

Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide

Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties

Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2

Alpha Synuclein Connects the Gut-Brain Axis in Parkinson’s Disease Patients – A View on Clinical Aspects, Cellular Pathology and Analytical Methodology

Functional Characterization of Colon Cancer-Associated Mutations in ADAM17 : Modifications in the Pro-Domain Interfere with Trafficking and Maturation

Editorial: Intracellular Mechanisms of α-Synuclein Processing

The Quest for Anti-α-Synuclein Antibody Specificity-Lessons Learnt From Flow Cytometry Analysis

LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease

Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models

Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson's Disease

Activation and Purification of ß‐Glucocerebrosidase by Exploiting its Transporter LIMP‐2 – Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease

Late‐onset Krabbe disease presenting as spastic paraplegia – implications of GCase and CTSB/D

Proteolysis of CD44 at the cell surface controls a downstream protease network

Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries

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