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Properties and functions of GAF domains in cyclic nucleotide phosphodiesterases and other proteins

Molecular pharmacology, 2004-02, Vol.65 (2), p.267-278

2004

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Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to the Phosphodiesterase-5 Catalytic Site Displays Potency, Specificity, Heterogeneity, and cGMP Stimulation

Molecular pharmacology, 2004-07, Vol.66 (1), p.144-152

2004

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Structural and Functional Features in Human PDE5A1 Regulatory Domain That Provide for Allosteric cGMP Binding, Dimerization, and Regulation

The Journal of biological chemistry, 2005-03, Vol.280 (12), p.12051-12063

2005

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Identification of Pyruvate Kinase in Methicillin-Resistant Staphylococcus aureus as a Novel Antimicrobial Drug Target

Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.2042-2053

2011

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Mapping the Protein Interaction Network in Methicillin-Resistant Staphylococcus aureus

Journal of proteome research, 2011-03, Vol.10 (3), p.1139-1150

2011

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The cAMP-Specific Phosphodiesterase TbPDE2C is an Essential Enzyme in Bloodstream Form Trypanosoma brucei

Proceedings of the National Academy of Sciences - PNAS, 2002-04, Vol.99 (7), p.4343-4348

2002

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A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiesterase-5 Dimerization

Molecular pharmacology, 2006-11, Vol.70 (5), p.1822-1831

2006

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Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors

The Journal of pharmacology and experimental therapeutics, 2007-11, Vol.323 (2), p.730

2007

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Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil

The Journal of pharmacology and experimental therapeutics, 2008-04, Vol.325 (1), p.62

2008

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Protein interaction networks as starting points to identify novel antimicrobial drug targets

Current opinion in microbiology, 2013-10, Vol.16 (5), p.566-572

2013

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Phosphodiesterase-5 Gln817 Is Critical for cGMP, Vardenafil, or Sildenafil Affinity

The Journal of biological chemistry, 2006-03, Vol.281 (9), p.5553-5558

2006

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Characterization of TbPDE2A, a Novel Cyclic Nucleotide-specific Phosphodiesterase from the Protozoan Parasite Trypanosoma brucei

The Journal of biological chemistry, 2001-04, Vol.276 (15), p.11559-11566

2001

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Methicillin-resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial Activities

The Journal of biological chemistry, 2011-12, Vol.286 (52), p.44716-44725

2011

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Multiple Conformations of Phosphodiesterase-5

The Journal of biological chemistry, 2006-07, Vol.281 (30), p.21469-21479

2006

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Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase

Journal of enzyme inhibition and medicinal chemistry, 2016-11, Vol.31 (6), p.1666-1671

2016

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Synthesis and MRSA PK inhibitory activity of thiazole containing deoxytopsentin analogues

Tetrahedron, 2014-10, Vol.70 (43), p.7845-7853

2014

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Multiple Conformations of Phosphodiesterase-5: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT

The Journal of biological chemistry, 2006-07, Vol.281 (30), p.21469-21479

2006

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Synthetic Analogues of the Marine Bisindole Deoxytopsentin: Potent Selective Inhibitors of MRSA Pyruvate Kinase

Journal of natural products (Washington, D.C.), 2015-03, Vol.78 (3), p.355-362

2015

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Functional Analysis, Overexpression, and Kinetic Characterization of Pyruvate Kinase from Methicillin-Resistant Staphylococcus aureus

Biochemistry (Easton), 2010-09, Vol.49 (35), p.7733-7747

2010

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Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections

Bioorganic & medicinal chemistry, 2014-03, Vol.22 (5), p.1708-1725

2014

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Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms

Bioorganic & medicinal chemistry letters, 2014-11, Vol.24 (21), p.5059-5062

2014

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Critical Amino Acids in Phosphodiesterase-5 Catalytic Site That Provide for High-Affinity Interaction with Cyclic Guanosine Monophosphate and Inhibitors

Biochemistry (Easton), 2007-11, Vol.46 (47), p.13554-13563

2007

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Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme

Cellular signalling, 2009-12, Vol.21 (12), p.1768-1774

2009

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Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents

Bioorganic & medicinal chemistry, 2012-12, Vol.20 (24), p.7069-7082

2012

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N-Terminal Domain of Phosphodiesterase-11A4 (PDE11A4) Decreases Affinity of the Catalytic Site for Substrates and Tadalafil, and is Involved in Oligomerization

Biochemistry (Easton), 2007-09, Vol.46 (36), p.10353-10364

2007

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Properties and functions of GAF domains in cyclic nucleotide phosphodiesterases and other proteins

Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to the Phosphodiesterase-5 Catalytic Site Displays Potency, Specificity, Heterogeneity, and cGMP Stimulation

Structural and Functional Features in Human PDE5A1 Regulatory Domain That Provide for Allosteric cGMP Binding, Dimerization, and Regulation

Identification of Pyruvate Kinase in Methicillin-Resistant Staphylococcus aureus as a Novel Antimicrobial Drug Target

Mapping the Protein Interaction Network in Methicillin-Resistant Staphylococcus aureus

The cAMP-Specific Phosphodiesterase TbPDE2C is an Essential Enzyme in Bloodstream Form Trypanosoma brucei

A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiesterase-5 Dimerization

Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors

Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil

Protein interaction networks as starting points to identify novel antimicrobial drug targets

Phosphodiesterase-5 Gln817 Is Critical for cGMP, Vardenafil, or Sildenafil Affinity

Characterization of TbPDE2A, a Novel Cyclic Nucleotide-specific Phosphodiesterase from the Protozoan Parasite Trypanosoma brucei

Methicillin-resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial Activities

Multiple Conformations of Phosphodiesterase-5

Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase

Synthesis and MRSA PK inhibitory activity of thiazole containing deoxytopsentin analogues

Multiple Conformations of Phosphodiesterase-5: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT

Synthetic Analogues of the Marine Bisindole Deoxytopsentin: Potent Selective Inhibitors of MRSA Pyruvate Kinase

Functional Analysis, Overexpression, and Kinetic Characterization of Pyruvate Kinase from Methicillin-Resistant Staphylococcus aureus

Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections

Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms

Critical Amino Acids in Phosphodiesterase-5 Catalytic Site That Provide for High-Affinity Interaction with Cyclic Guanosine Monophosphate and Inhibitors

Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme

Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents

N-Terminal Domain of Phosphodiesterase-11A4 (PDE11A4) Decreases Affinity of the Catalytic Site for Substrates and Tadalafil, and is Involved in Oligomerization

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