UB Paderborn / Katalog / Suche / in CDI

Quadruple Target Evaluation of Diversity-Optimized Halogen-Enriched Fragments (HEFLibs) Reveals Substantial Ligand Efficiency for AP2-Associated Protein Kinase 1 (AAK1)

Frontiers in chemistry, 2022-02, Vol.9, p.815567-815567

2022

Link zum Volltext

Verfügbarkeit prüfen

Discovery of Ircinianin Lactones B and C—Two New Cyclic Sesterterpenes from the Marine Sponge Ircinia wistarii

Marine drugs, 2022-08, Vol.20 (8), p.532

2022

Link zum Volltext

Verfügbarkeit prüfen

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

Journal of medicinal chemistry, 2013-02, Vol.56 (4), p.1363-1388

2013

Link zum Volltext

Verfügbarkeit prüfen

Addressing Methionine in Molecular Design through Directed Sulfur–Halogen Bonds

Journal of chemical theory and computation, 2011-07, Vol.7 (7), p.2307-2315

2011

Link zum Volltext

Verfügbarkeit prüfen

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

ACS chemical biology, 2015-12, Vol.10 (12), p.2725-2732

2015

Link zum Volltext

Verfügbarkeit prüfen

Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes

Journal of medicinal chemistry, 2022-11, Vol.65 (21), p.14539-14552

2022

Link zum Volltext

Verfügbarkeit prüfen

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Journal of the American Chemical Society, 2012-04, Vol.134 (15), p.6810-6818

2012

Link zum Volltext

Verfügbarkeit prüfen

Principles and Applications of CF2X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery

Journal of medicinal chemistry, 2023-08, Vol.66 (15), p.10202-10225

2023

Link zum Volltext

Verfügbarkeit prüfen

Principles and Applications of CF 2 X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery

Journal of medicinal chemistry, 2023-08, Vol.66 (15), p.10202-10225

2023

Link zum Volltext

Verfügbarkeit prüfen

Scaffold Effects on Halogen Bonding Strength

Journal of chemical information and modeling, 2019-02, Vol.59 (2), p.885-894

2019

Link zum Volltext

Verfügbarkeit prüfen

Evaluating the Potential of Halogen Bonding in Molecular Design: Automated Scaffold Decoration Using the New Scoring Function XBScore

Journal of chemical information and modeling, 2015-03, Vol.55 (3), p.687-699

2015

Link zum Volltext

Verfügbarkeit prüfen

Using halogen bonds to address the protein backbone: a systematic evaluation

Journal of computer-aided molecular design, 2012-08, Vol.26 (8), p.935-945

2012

Link zum Volltext

Verfügbarkeit prüfen

Targeting the Gatekeeper MET146 of C‑Jun N‑Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond

Journal of the American Chemical Society, 2015-11, Vol.137 (46), p.14640-14652

2015

Link zum Volltext

Verfügbarkeit prüfen

Synthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4

Drug design, development and therapy, 2023-01, Vol.17, p.1247-1274

2023

Link zum Volltext

Verfügbarkeit prüfen

Using Surface Scans for the Evaluation of Halogen Bonds toward the Side Chains of Aspartate, Asparagine, Glutamate, and Glutamine

Journal of chemical information and modeling, 2016-07, Vol.56 (7), p.1373-1383

2016

Link zum Volltext

Verfügbarkeit prüfen

Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C

RSC medicinal chemistry, 2022-12, Vol.13 (12), p.1575-1586

2022

Link zum Volltext

Verfügbarkeit prüfen

Targeting Histidine Side Chains in Molecular Design through Nitrogen–Halogen Bonds

Journal of chemical information and modeling, 2013-12, Vol.53 (12), p.3178-3189

2013

Link zum Volltext

Verfügbarkeit prüfen

Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.961-965

2012

Link zum Volltext

Verfügbarkeit prüfen

Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery

Future medicinal chemistry, 2014-04, Vol.6 (6), p.617-639

2014

Link zum Volltext

Verfügbarkeit prüfen

Intramolecular signaling in tandem-GAF domains from PDE5 and PDE10 studied with a cyanobacterial adenylyl cyclase reporter

Cellular signalling, 2012-03, Vol.24 (3), p.629-634

2012

Link zum Volltext

Verfügbarkeit prüfen

11th German Conference on Chemoinformatics (GCC 2015): Fulda, Germany. 8–10 November 2015

Journal of cheminformatics, 2016-04, Vol.8 (Suppl 1), p.18-18, Article 18

2016

Link zum Volltext

Verfügbarkeit prüfen

11th German Conference on Chemoinformatics

Journal of cheminformatics, 2016-04, Vol.8 (1)

2016

Link zum Volltext

Verfügbarkeit prüfen

Protective role of Arapaima gigas fish scales: Structure and mechanical behavior

Acta biomaterialia, 2014-08, Vol.10 (8), p.3599-3614

2014

Link zum Volltext

Verfügbarkeit prüfen

Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA

Clinical infectious diseases, 2022-03, Vol.74 (5), p.905-908

2022

Link zum Volltext

Verfügbarkeit prüfen

Immune-Response Patterns and Next Generation Sequencing Diagnostics for the Detection of Mycoses in Patients with Septic Shock-Results of a Combined Clinical and Experimental Investigation

International journal of molecular sciences, 2017-08, Vol.18 (8), p.1796

2017

Link zum Volltext

Verfügbarkeit prüfen

Menü

Weitere Dienste

Einstellungen

Quadruple Target Evaluation of Diversity-Optimized Halogen-Enriched Fragments (HEFLibs) Reveals Substantial Ligand Efficiency for AP2-Associated Protein Kinase 1 (AAK1)

Discovery of Ircinianin Lactones B and C—Two New Cyclic Sesterterpenes from the Marine Sponge Ircinia wistarii

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

Addressing Methionine in Molecular Design through Directed Sulfur–Halogen Bonds

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Principles and Applications of CF2X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery

Principles and Applications of CF 2 X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery

Scaffold Effects on Halogen Bonding Strength

Evaluating the Potential of Halogen Bonding in Molecular Design: Automated Scaffold Decoration Using the New Scoring Function XBScore

Using halogen bonds to address the protein backbone: a systematic evaluation

Targeting the Gatekeeper MET146 of C‑Jun N‑Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond

Synthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4

Using Surface Scans for the Evaluation of Halogen Bonds toward the Side Chains of Aspartate, Asparagine, Glutamate, and Glutamine

Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C

Targeting Histidine Side Chains in Molecular Design through Nitrogen–Halogen Bonds

Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases

Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery

Intramolecular signaling in tandem-GAF domains from PDE5 and PDE10 studied with a cyanobacterial adenylyl cyclase reporter

11th German Conference on Chemoinformatics (GCC 2015): Fulda, Germany. 8–10 November 2015

11th German Conference on Chemoinformatics

Protective role of Arapaima gigas fish scales: Structure and mechanical behavior

Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA

Immune-Response Patterns and Next Generation Sequencing Diagnostics for the Detection of Mycoses in Patients with Septic Shock-Results of a Combined Clinical and Experimental Investigation

Suchergebnisse filtern