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The Yin and Yang of nucleic acid-based therapy in the brain

Progress in neurobiology, 2017-08, Vol.155, p.194-211

2017

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Synthetic long non-coding RNAs [SINEUPs] rescue defective gene expression in vivo

Scientific reports, 2016-06, Vol.6 (1), p.27315, Article 27315

2016

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A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer’s disease

PloS one, 2022-08, Vol.17 (8), p.e0273036-e0273036

2022

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Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease

Frontiers in cellular neuroscience, 2015-04, Vol.9, p.114-114

2015

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HMGA2 Antisense Long Non-coding RNAs as New Players in the Regulation of HMGA2 Expression and Pancreatic Cancer Promotion

Frontiers in oncology, 2020-01, Vol.9, p.1526

2020

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Hemoglobin is present as a canonical α2β2 tetramer in dopaminergic neurons

Biochimica et biophysica acta, 2013-09, Vol.1834 (9), p.1939-1943

2013

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Identification of functional features of synthetic SINEUPs, antisense lncRNAs that specifically enhance protein translation

PloS one, 2018-02, Vol.13 (2), p.e0183229-e0183229

2018

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TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains

Human molecular genetics, 2010-10, Vol.19 (19), p.3759-3770

2010

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Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naïve CD4+ T cells

Frontiers in immunology, 2022-09, Vol.13, p.915963-915963

2022

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Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6

PloS one, 2012-04, Vol.7 (4), p.e35051-e35051

2012

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Engineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAs

Computational and structural biotechnology journal, 2016-01, Vol.14 (C), p.404-410

2016

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Bestrophin-2 Is a Candidate Calcium-Activated Chloride Channel Involved in Olfactory Transduction

Proceedings of the National Academy of Sciences - PNAS, 2006-08, Vol.103 (34), p.12929-12934

2006

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Promoter architecture of mouse olfactory receptor genes

Genome research, 2012-03, Vol.22 (3), p.486-497

2012

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Parkinson Disease-associated DJ-1 Is Required for the Expression of the Glial Cell Line-derived Neurotrophic Factor Receptor RET in Human Neuroblastoma Cells

The Journal of biological chemistry, 2010-06, Vol.285 (24), p.18565-18574

2010

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Gut-Ex-Vivo system as a model to study gluten response in celiac disease

Cell death discovery, 2021-03, Vol.7 (1), p.45-10, Article 45

2021

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Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation

FEBS letters, 2020-12, Vol.594 (24), p.4357-4369

2020

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Identification of antisense long noncoding RNAs that function as SINEUPs in human cells

Scientific reports, 2016-09, Vol.6 (1), p.33605-33605, Article 33605

2016

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Conformational ensembles of an RNA hairpin using molecular dynamics and sparse NMR data

Nucleic acids research, 2020-02, Vol.48 (3), p.1164-1174

2020

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Enhancing B- and T-Cell Immune Response to a Hepatitis C Virus E2 DNA Vaccine by Intramuscular Electrical Gene Transfer

Journal of Virology, 2000-12, Vol.74 (24), p.11598-11607

2000

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Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

Nature (London), 2012-11, Vol.491 (7424), p.454-457

2012

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SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson’s Disease

Molecular therapy, 2020-02, Vol.28 (2), p.642-652

2020

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SINEUP non-coding RNAs rescue defective frataxin expression and activity in a cellular model of Friedreich's Ataxia

Nucleic acids research, 2019-11, Vol.47 (20), p.10728-10743

2019

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SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies

Nucleic acids research, 2020-11, Vol.48 (20), p.11626-11644

2020

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The RNA‐binding protein ILF3 binds to transposable element sequences in SINEUP lncRNAs

The FASEB journal, 2019-12, Vol.33 (12), p.13572-13589

2019

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Structural determinants of the SINE B2 element embedded in the long non-coding RNA activator of translation AS Uchl1

Scientific reports, 2018-02, Vol.8 (1), p.3189-13, Article 3189

2018

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The Yin and Yang of nucleic acid-based therapy in the brain

Synthetic long non-coding RNAs [SINEUPs] rescue defective gene expression in vivo

A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer’s disease

Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease

HMGA2 Antisense Long Non-coding RNAs as New Players in the Regulation of HMGA2 Expression and Pancreatic Cancer Promotion

Hemoglobin is present as a canonical α2β2 tetramer in dopaminergic neurons

Identification of functional features of synthetic SINEUPs, antisense lncRNAs that specifically enhance protein translation

TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains

Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naïve CD4+ T cells

Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6

Engineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAs

Bestrophin-2 Is a Candidate Calcium-Activated Chloride Channel Involved in Olfactory Transduction

Promoter architecture of mouse olfactory receptor genes

Parkinson Disease-associated DJ-1 Is Required for the Expression of the Glial Cell Line-derived Neurotrophic Factor Receptor RET in Human Neuroblastoma Cells

Gut-Ex-Vivo system as a model to study gluten response in celiac disease

Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation

Identification of antisense long noncoding RNAs that function as SINEUPs in human cells

Conformational ensembles of an RNA hairpin using molecular dynamics and sparse NMR data

Enhancing B- and T-Cell Immune Response to a Hepatitis C Virus E2 DNA Vaccine by Intramuscular Electrical Gene Transfer

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson’s Disease

SINEUP non-coding RNAs rescue defective frataxin expression and activity in a cellular model of Friedreich's Ataxia

SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies

The RNA‐binding protein ILF3 binds to transposable element sequences in SINEUP lncRNAs

Structural determinants of the SINE B2 element embedded in the long non-coding RNA activator of translation AS Uchl1

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