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Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: Potential prospects for combined targeted therapeutics

International journal of oncology, 2012-08, Vol.41 (2), p.393-406

2012

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Delayed kinetics of DNA double‐strand break processing in normal and pathological aging

Aging cell, 2008-02, Vol.7 (1), p.89-100

2008

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DLC1 Interaction with α-Catenin Stabilizes Adherens Junctions and Enhances DLC1 Antioncogenic Activity

Molecular and Cellular Biology, 2012-06, Vol.32 (11), p.2145-2159

2012

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Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair

Nature Medicine, 2001-08, Vol.7 (8), p.961-966

2001

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Telomerase Contributes to Tumorigenesis by a Telomere Length-Independent Mechanism

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (20), p.12606-12611

2002

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DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity

Oncogene, 2003-01, Vol.22 (3), p.445-450

2003

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DLC1 Interaction with S100A10 Mediates Inhibition of In Vitro Cell Invasion and Tumorigenicity of Lung Cancer Cells through a RhoGAP-Independent Mechanism

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8), p.2916-2925

2011

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POTE paralogs are induced and differentially expressed in many cancers

Cancer research (Chicago, Ill.), 2006, Vol.66 (1), p.52-56

2006

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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

Nature cell biology, 2004-02, Vol.6 (2), p.168-170

2004

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POTE, a Highly Homologous Gene Family Located on Numerous Chromosomes and Expressed in Prostate, Ovary, Testis, Placenta, and Prostate Cancer

Proceedings of the National Academy of Sciences - PNAS, 2002-12, Vol.99 (26), p.16975-16980

2002

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DLC‐1:a Rho GTPase‐activating protein and tumour suppressor

Journal of cellular and molecular medicine, 2007-09, Vol.11 (5), p.1185-1207

2007

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Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity

Cancer research (Chicago, Ill.), 2007-09, Vol.67 (17), p.8131-8138

2007

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

Genes & development, 2001-01, Vol.15 (1), p.50-65

2001

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Amplification and Overexpression of the EMS 1 Oncogene, a Possible Prognostic Marker, in Human Hepatocellular Carcinoma

The Journal of molecular diagnostics : JMD, 2003-02, Vol.5 (1), p.48-53

2003

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In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

BMC cancer, 2013-04, Vol.13 (1), p.198-198, Article 198

2013

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Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13

Oncogene, 1998-02, Vol.16 (6), p.817-824

1998

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claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing

Molecular and Cellular Biology, 2001-11, Vol.21 (21), p.7380-7390

2001

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Nonclassic functions of human topoisomerase I: Genome-wide and pharmacologic analyses

Cancer research (Chicago, Ill.), 2007-09, Vol.67 (18), p.8752-8761

2007

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DLC1 suppresses NF-κB activity in prostate cancer cells due to its stabilizing effect on adherens junctions

SpringerPlus, 2014-01, Vol.3 (1), p.27-12, Article 27

2014

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Human Mitochondrial Topoisomerase I

Proceedings of the National Academy of Sciences - PNAS, 2001-09, Vol.98 (19), p.10608-10613

2001

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High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expression

Blood, 2003-09, Vol.102 (5), p.1857-1865

2003

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Natural melatonin `knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase

Brain research. Molecular brain research., 1998-12, Vol.63 (1), p.189-197

1998

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Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP

Cancer research (Chicago, Ill.), 1998-05, Vol.58 (10), p.2196-2199

1998

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SMAD5 Gene Expression, Rearrangements, Copy Number, Amplification at Fragile Site FRA5C in Human Hepatocellular Carcinoma

Neoplasia (New York, N.Y.), 2003-09, Vol.5 (5), p.390-396

2003

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DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis

International journal of oncology, 2008-06, Vol.32 (6), p.1285-1291

2008

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Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: Potential prospects for combined targeted therapeutics

Delayed kinetics of DNA double‐strand break processing in normal and pathological aging

DLC1 Interaction with α-Catenin Stabilizes Adherens Junctions and Enhances DLC1 Antioncogenic Activity

Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair

Telomerase Contributes to Tumorigenesis by a Telomere Length-Independent Mechanism

DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity

DLC1 Interaction with S100A10 Mediates Inhibition of In Vitro Cell Invasion and Tumorigenicity of Lung Cancer Cells through a RhoGAP-Independent Mechanism

POTE paralogs are induced and differentially expressed in many cancers

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

POTE, a Highly Homologous Gene Family Located on Numerous Chromosomes and Expressed in Prostate, Ovary, Testis, Placenta, and Prostate Cancer

DLC‐1:a Rho GTPase‐activating protein and tumour suppressor

Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

Amplification and Overexpression of the EMS 1 Oncogene, a Possible Prognostic Marker, in Human Hepatocellular Carcinoma

In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13

claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing

Nonclassic functions of human topoisomerase I: Genome-wide and pharmacologic analyses

DLC1 suppresses NF-κB activity in prostate cancer cells due to its stabilizing effect on adherens junctions

Human Mitochondrial Topoisomerase I

High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expression

Natural melatonin `knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase

Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP

SMAD5 Gene Expression, Rearrangements, Copy Number, Amplification at Fragile Site FRA5C in Human Hepatocellular Carcinoma

DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis

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