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Phase 1 study of capmatinib in MET‐positive solid tumor patients: Dose escalation and expansion of selected cohorts

Cancer science, 2020-02, Vol.111 (2), p.536-547

2020

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Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model

Journal of applied toxicology, 2016-02, Vol.36 (2), p.320-329

2016

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New paradigm for expediting drug development in Asia

Drug discovery today, 2020-03, Vol.25 (3), p.491-496

2020

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Phase Ib/II Study of Capmatinib (INC280) Plus Gefitinib After Failure of Epidermal Growth Factor Receptor (EGFR) Inhibitor Therapy in Patients With EGFR-Mutated, MET Factor-Dysregulated Non-Small-Cell Lung Cancer

Journal of clinical oncology, 2018-11, Vol.36 (31), p.3101-3109

2018

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Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite

Drug metabolism and disposition, 2020-10, Vol.48 (10), p.873-885

2020

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RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models

Cancer research (Chicago, Ill.), 2010-07, Vol.70 (13), p.5518-5527

2010

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The first-in-human study of the pan-PIM kinase inhibitor PIM447 in patients with relapsed and/or refractory multiple myeloma

Leukemia, 2019-12, Vol.33 (12), p.2924-2933

2019

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Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation

Journal of medicinal chemistry, 2022-07, Vol.65 (13), p.8713-8734

2022

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Are you laughing with me or at me? Psychopathic traits and the ability to distinguish between affiliation and dominance laughter cues

Journal of personality, 2022-08, Vol.90 (4), p.631-644

2022

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The clinical effects of inclisiran, a first-in-class LDL-C lowering siRNA therapy, on the LDL-C levels in Chinese patients with hypercholesterolemia

Journal of clinical lipidology, 2023-05, Vol.17 (3), p.392-400

2023

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A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma

Journal of neuro-oncology, 2020-01, Vol.146 (1), p.79-89

2020

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A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR monoclonal antibody treatment

Investigational new drugs, 2020-12, Vol.38 (6), p.1774-1783

2020

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Substrate Dependent Inhibition Profiles of Fourteen Drugs on CYP3A4 Activity Measured by A High Throughput LCMS/MS Method with Four Probe Drugs, Midazolam, Testosterone, Nifedipine and Terfenadine

Drug metabolism and pharmacokinetics, 2003, Vol.18 (2), p.128-138

2003

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4 β -Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys

Drug metabolism and disposition, 2014-05, Vol.42 (5), p.839-843

2014

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ACTR-74. A PHASE IB/II, OPEN-LABEL, MULTICENTER STUDY OF CAPMATINIB (INC280) ALONE AND IN COMBINATION WITH BUPARLISIB (BKM120) IN ADULT PATIENTS WITH RECURRENT GLIOBLASTOMA

Neuro-oncology (Charlottesville, Va.), 2017-11, Vol.19 (suppl_6), p.vi16-vi17

2017

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4β-Hydroxycholesterol as an endogenous biomarker of CYP3A activity in cynomolgus monkeys

Drug metabolism and disposition, 2014-05, Vol.42 (5), p.839

2014

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In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401

European journal of drug metabolism and pharmacokinetics, 2019-10, Vol.44 (5), p.669-680

2019

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Safety and efficacy of INC280 in combination with gefitinib (gef) in patients with EGFR -mutated (mut), MET-positive NSCLC: A single-arm phase lb/ll study

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.8017-8017

2014

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Phase I study of the safety and efficacy of INC280 in patients with advanced MET-dependent solid tumors

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.2520-2520

2014

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Long-tailed macaque reliance on anthropogenic food with potential conflicts toward humans in the campus of Universiti Malaysia Sabah

MAMMAL STUDY, 2023-10, Vol.48 (4), p.273-281

2023

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Substrate Dependent Inhibition Profiles of Fourteen Drugs on CYP3A4 Activity Measured by A High Throughput LCMS/MS Method with Four Probe Drugs, Midazolam, Testosterone, Nifedipine and Terfenadine

DRUG METABOLISM AND PHARMACOKINETICS, 2003, Vol.18 (2), p.128-138

2003

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Catecholic iron complexes as cytoprotective superoxide scavengers against hypoxia:reoxygenation injury in isolated hepatocytes

Biochemical pharmacology, 1998-10, Vol.56 (7), p.825-830

1998

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The Prevention of CCl4-Induced Liver Necrosis in Mice by Naturally Occurring Methylenedioxybenzenes

Toxicology and applied pharmacology, 1996-10, Vol.140 (2), p.411-421

1996

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The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants

Chemico-biological interactions, 1997-12, Vol.108 (1), p.107-118

1997

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Chemoprotective properties of naturally occurring methylenedioxybenzenes and catecholic metabolites

Zhao, Ziwei Sylvia

1998

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Phase 1 study of capmatinib in MET‐positive solid tumor patients: Dose escalation and expansion of selected cohorts

Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model

New paradigm for expediting drug development in Asia

Phase Ib/II Study of Capmatinib (INC280) Plus Gefitinib After Failure of Epidermal Growth Factor Receptor (EGFR) Inhibitor Therapy in Patients With EGFR-Mutated, MET Factor-Dysregulated Non-Small-Cell Lung Cancer

Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite

RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models

The first-in-human study of the pan-PIM kinase inhibitor PIM447 in patients with relapsed and/or refractory multiple myeloma

Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation

Are you laughing with me or at me? Psychopathic traits and the ability to distinguish between affiliation and dominance laughter cues

The clinical effects of inclisiran, a first-in-class LDL-C lowering siRNA therapy, on the LDL-C levels in Chinese patients with hypercholesterolemia

A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma

A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR monoclonal antibody treatment

Substrate Dependent Inhibition Profiles of Fourteen Drugs on CYP3A4 Activity Measured by A High Throughput LCMS/MS Method with Four Probe Drugs, Midazolam, Testosterone, Nifedipine and Terfenadine

4 β -Hydroxycholesterol as an Endogenous Biomarker of CYP3A Activity in Cynomolgus Monkeys

ACTR-74. A PHASE IB/II, OPEN-LABEL, MULTICENTER STUDY OF CAPMATINIB (INC280) ALONE AND IN COMBINATION WITH BUPARLISIB (BKM120) IN ADULT PATIENTS WITH RECURRENT GLIOBLASTOMA

4β-Hydroxycholesterol as an endogenous biomarker of CYP3A activity in cynomolgus monkeys

In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401

Safety and efficacy of INC280 in combination with gefitinib (gef) in patients with EGFR -mutated (mut), MET-positive NSCLC: A single-arm phase lb/ll study

Phase I study of the safety and efficacy of INC280 in patients with advanced MET-dependent solid tumors

Long-tailed macaque reliance on anthropogenic food with potential conflicts toward humans in the campus of Universiti Malaysia Sabah

Substrate Dependent Inhibition Profiles of Fourteen Drugs on CYP3A4 Activity Measured by A High Throughput LCMS/MS Method with Four Probe Drugs, Midazolam, Testosterone, Nifedipine and Terfenadine

Catecholic iron complexes as cytoprotective superoxide scavengers against hypoxia:reoxygenation injury in isolated hepatocytes

The Prevention of CCl4-Induced Liver Necrosis in Mice by Naturally Occurring Methylenedioxybenzenes

The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants

Chemoprotective properties of naturally occurring methylenedioxybenzenes and catecholic metabolites

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