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Fabp3 as a Biomarker of Skeletal Muscle Toxicity in the Rat: Comparison with Conventional Biomarkers

Toxicological sciences, 2008-06, Vol.103 (2), p.382-396

2008

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Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Journal of medicinal chemistry, 2003-11, Vol.46 (24), p.5121-5124

2003

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In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461

The Journal of pharmacology and experimental therapeutics, 1997-10, Vol.283 (1), p.157

1997

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Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor

Journal of medicinal chemistry, 2023-12, Vol.66 (23), p.15960-15976

2023

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Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide‑1 Receptor

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3439-3448

2021

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Design and synthesis of novel and potent amide linked PPARγ/δ dual agonists

Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6744-6749

2007

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Tetrahydroisoquinoline PPARγ agonists: Design of novel, highly selective non-TZD antihyperglycemic agents

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (24), p.6293-6297

2006

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Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption

Journal of medicinal chemistry, 1998-03, Vol.41 (6), p.973-980

1998

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Comparative Pharmacokinetics Studies of Immediate- and Modified-Release Formulations of Glipizide in Pigs and Dogs

Journal of pharmaceutical sciences, 2012-11, Vol.101 (11), p.4327-4336

2012

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N-Acyloxymethyl carbamate linked prodrugs of pseudomycins are novel antifungal agents

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (14), p.1875-1879

2001

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Pharmacokinetics of intravenous and oral metformin and r,s-verapamil in Sinclair, Hanford, Yucatan and Göttingen minipigs

International journal of pharmacokinetics, 2017-05, Vol.2 (2), p.81-91

2017

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P4 and P1′ optimization of bicycloproline P2 bearing tetrapeptidyl α-ketoamides as HCV protease inhibitors

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (19), p.5007-5011

2004

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Design and Synthesis of Dual Peroxisome Proliferator-Activated Receptors γ and δ Agonists as Novel Euglycemic Agents with a Reduced Weight Gain Profile

Journal of medicinal chemistry, 2006-09, Vol.49 (19), p.5649-5652

2006

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Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.251-256

2004

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The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios

Pharmaceutical research, 2002-11, Vol.19 (11), p.1606-1621

2002

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Design and synthesis of a novel class of dual PPARγ/δ agonists

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.1052-1055

2007

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P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl α-ketoamide based HCV protease inhibitors

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.257-261

2004

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Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6

Biochemical pharmacology, 1996-01, Vol.51 (2), p.165-172

1996

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Syn and anti bent hydrazine radical cations. Effect of .sigma.,.pi. mixing on spectral properties

Journal of the American Chemical Society, 1985-01, Vol.107 (1), p.143-149

1985

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Fate of free radicals generated during one-electron reductions of 4-alkyl-1,4-peroxyquinols by cytochrome P 450

Chemical research in toxicology, 1988-11, Vol.1 (6), p.385-390

1988

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Design and synthesis of a novel class of dual PPARgamma/delta agonists

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.1052-1055

2007

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Design and synthesis of a novel class of dual PPAR^g/^d agonists

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.1052-1055

2007

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The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)

Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus

Fabp3 as a Biomarker of Skeletal Muscle Toxicity in the Rat: Comparison with Conventional Biomarkers

Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461

Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor

Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide‑1 Receptor

Design and synthesis of novel and potent amide linked PPARγ/δ dual agonists

Tetrahydroisoquinoline PPARγ agonists: Design of novel, highly selective non-TZD antihyperglycemic agents

Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption

Comparative Pharmacokinetics Studies of Immediate- and Modified-Release Formulations of Glipizide in Pigs and Dogs

N-Acyloxymethyl carbamate linked prodrugs of pseudomycins are novel antifungal agents

Pharmacokinetics of intravenous and oral metformin and r,s-verapamil in Sinclair, Hanford, Yucatan and Göttingen minipigs

P4 and P1′ optimization of bicycloproline P2 bearing tetrapeptidyl α-ketoamides as HCV protease inhibitors

Design and Synthesis of Dual Peroxisome Proliferator-Activated Receptors γ and δ Agonists as Novel Euglycemic Agents with a Reduced Weight Gain Profile

Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios

Design and synthesis of a novel class of dual PPARγ/δ agonists

P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl α-ketoamide based HCV protease inhibitors

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6

Syn and anti bent hydrazine radical cations. Effect of .sigma.,.pi. mixing on spectral properties

Fate of free radicals generated during one-electron reductions of 4-alkyl-1,4-peroxyquinols by cytochrome P 450

Design and synthesis of a novel class of dual PPARgamma/delta agonists

Design and synthesis of a novel class of dual PPAR^g/^d agonists

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