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Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1184-1192

2016

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In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461

The Journal of pharmacology and experimental therapeutics, 1997-10, Vol.283 (1), p.157

1997

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The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios

Pharmaceutical research, 2002-11, Vol.19 (11), p.1606-1621

2002

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Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Journal of medicinal chemistry, 2003-11, Vol.46 (24), p.5121-5124

2003

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Mechanistic aspects of cytochrome P-450-hydroperoxide interactions: substituent effects on degradative pathways

Drug metabolism reviews, 1989, Vol.20 (2-4), p.365-378

1989

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Fate of free radicals generated during one-electron reductions of 4-alkyl-1,4-peroxyquinols by cytochrome P 450

Chemical research in toxicology, 1988-11, Vol.1 (6), p.385-390

1988

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Syn and anti bent hydrazine radical cations. Effect of .sigma.,.pi. mixing on spectral properties

Journal of the American Chemical Society, 1985-01, Vol.107 (1), p.143-149

1985

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Conformations of hexahydropyridazine cation radicals

Journal of organic chemistry, 1985-11, Vol.50 (24), p.4749-4753

1985

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Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.251-256

2004

Volltextzugriff (PDF)

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6

Biochemical pharmacology, 1996-01, Vol.51 (2), p.165-172

1996

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Design and synthesis of fluorinated RXR modulators

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3191-3195

2003

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Design and synthesis of novel RXR-selective modulators with improved pharmacological profile

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4071-4075

2003

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Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine

International archives of allergy and immunology, 1995-05, Vol.107 (1-3), p.420

1995

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(−)-SCH 57939: synthesis and pharmacological properties of a potent, metabolically stable cholesterol absorption inhibitor

Bioorganic & medicinal chemistry letters, 1996-09, Vol.6 (17), p.2069-2072

1996

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Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine

Biochemical pharmacology, 1996-01, Vol.51 (2), p.165-172

1996

Volltextzugriff (PDF)

ChemInform Abstract: (-)-SCH 57939: Synthesis and Pharmacological Properties of a Potent, Metabolically Stable Cholesterol Absorption Inhibitor

ChemInform, 1996-12, Vol.27 (52), p.no-no

1996

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Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats

In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461

The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Mechanistic aspects of cytochrome P-450-hydroperoxide interactions: substituent effects on degradative pathways

Fate of free radicals generated during one-electron reductions of 4-alkyl-1,4-peroxyquinols by cytochrome P 450

Syn and anti bent hydrazine radical cations. Effect of .sigma.,.pi. mixing on spectral properties

Conformations of hexahydropyridazine cation radicals

Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus

Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6

Design and synthesis of fluorinated RXR modulators

Design and synthesis of novel RXR-selective modulators with improved pharmacological profile

Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine

(−)-SCH 57939: synthesis and pharmacological properties of a potent, metabolically stable cholesterol absorption inhibitor

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine

ChemInform Abstract: (-)-SCH 57939: Synthesis and Pharmacological Properties of a Potent, Metabolically Stable Cholesterol Absorption Inhibitor

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