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Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

Hepatology (Baltimore, Md.), 2008-11, Vol.48 (5), p.1632-1643

2008

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The G‐Protein‐coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light‐chain enhancer of activated B cells (NF‐κB) in mice

Hepatology (Baltimore, Md.), 2011-10, Vol.54 (4), p.1421-1432

2011

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Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

Hepatology (Baltimore, Md.), 2016-09, Vol.64 (3), p.760-773

2016

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Discovery of novel modulators for the PPARα (peroxisome proliferator activated receptor α): Potential therapies for nonalcoholic fatty liver disease

Bioorganic & medicinal chemistry, 2021-07, Vol.41, p.116193-116193, Article 116193

2021

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Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor

Bioorganic & medicinal chemistry, 2014-06, Vol.22 (11), p.2919-2938

2014

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Novel FXR (farnesoid X receptor) modulators: Potential therapies for cholesterol gallstone disease

Bioorganic & medicinal chemistry, 2016-09, Vol.24 (18), p.3986-3993

2016

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Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery

Bioorganic & medicinal chemistry, 2013-07, Vol.21 (14), p.4266-4278

2013

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GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells

PloS one, 2014-04, Vol.9 (4), p.e93567

2014

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Identification of novel inverse agonists of estrogen-related receptors ERRγ and ERRβ

Bioorganic & medicinal chemistry, 2017-03, Vol.25 (5), p.1585-1599

2017

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Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled Bile acid receptor 1 (GP-BAR1, TGR5) agonists

Bioorganic & medicinal chemistry, 2015-04, Vol.23 (7), p.1613-1628

2015

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Farnesoid X receptor alleviates age‐related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription

Hepatology (Baltimore, Md.), 2010-03, Vol.51 (3), p.953-962

2010

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FXR Protects Lung from Lipopolysaccharide-Induced Acute Injury

Molecular endocrinology (Baltimore, Md.), 2012-01, Vol.26 (1), p.27-36

2012

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An improved synthesis of 6α-ethylchenodeoxycholic acid (6ECDCA), a potent and selective agonist for the Farnesoid X Receptor (FXR)

Steroids, 2012-11, Vol.77 (13), p.1335-1338

2012

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Simple and Efficient Production of (Z)-4-Hydroxytamoxifen, a Potent Estrogen Receptor Modulator

Journal of organic chemistry, 2003-11, Vol.68 (24), p.9489-9491

2003

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Identification of an agonist ligand for estrogen-related receptors ERRβ/γ

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (5), p.1311-1313

2005

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The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-κB Signaling Pathway

Frontiers in pharmacology, 2015-12, Vol.6, p.287-287

2015

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The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling pathways

Oncotarget, 2017-08, Vol.8 (33), p.54378-54387

2017

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The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway

Oncotarget, 2015-10, Vol.6 (33), p.34402-34413

2015

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Deficiency of G‐protein‐coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis

Hepatology (Baltimore, Md.), 2013-02, Vol.57 (2), p.656-666

2013

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The G-protein coupled bile acid receptor Gpbar1 (TGR5) negatively regulates hepatic inflammatory response through antagonizing Nuclear Factor κB

Hepatology (Baltimore, Md.), 2011-08, Vol.54 (4), p.1421-1432

2011

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The G-Protein-Coupled Bile Acid Receptor, Gpbarl (TGR5), Negatively Regulates Hepatic Inflammatory Response Through Antagonizing Nuclear Factor Kappa Light-Chain Enhancer of Activated B Cells (NF-κB) in Mice

Hepatology (Baltimore, Md.), 2011, Vol.54 (4), p.1421-1432

2011

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Tu1862 TGR5 Signaling Protects Against Inflammatory Bowel Diseases Through Antagonizing NF-κB Signaling and Reactive Oxygen Species Generation

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-863-S-863

2012

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Farnesoid X receptor antagonizes NF-κB in hepatic inflammatory response

Hepatology (Baltimore, Md.), 2008-11, Vol.48 (5), p.1632-1643

2008

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Activation of farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers

Hepatology (Baltimore, Md.), 2010-03, Vol.51 (3), p.953-962

2010

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Farnesoid X Receptor Alleviates Age-Related Proliferation Defects in Regenerating Mouse Livers by Activating Forkhead Box mlb Transcription

Hepatology (Baltimore, Md.), 2010, Vol.51 (3), p.953-962

2010

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Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

The G‐Protein‐coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light‐chain enhancer of activated B cells (NF‐κB) in mice

Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

Discovery of novel modulators for the PPARα (peroxisome proliferator activated receptor α): Potential therapies for nonalcoholic fatty liver disease

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor

Novel FXR (farnesoid X receptor) modulators: Potential therapies for cholesterol gallstone disease

Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery

GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells

Identification of novel inverse agonists of estrogen-related receptors ERRγ and ERRβ

Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled Bile acid receptor 1 (GP-BAR1, TGR5) agonists

Farnesoid X receptor alleviates age‐related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription

FXR Protects Lung from Lipopolysaccharide-Induced Acute Injury

An improved synthesis of 6α-ethylchenodeoxycholic acid (6ECDCA), a potent and selective agonist for the Farnesoid X Receptor (FXR)

Simple and Efficient Production of (Z)-4-Hydroxytamoxifen, a Potent Estrogen Receptor Modulator

Identification of an agonist ligand for estrogen-related receptors ERRβ/γ

The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-κB Signaling Pathway

The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling pathways

The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway

Deficiency of G‐protein‐coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis

The G-protein coupled bile acid receptor Gpbar1 (TGR5) negatively regulates hepatic inflammatory response through antagonizing Nuclear Factor κB

The G-Protein-Coupled Bile Acid Receptor, Gpbarl (TGR5), Negatively Regulates Hepatic Inflammatory Response Through Antagonizing Nuclear Factor Kappa Light-Chain Enhancer of Activated B Cells (NF-κB) in Mice

Tu1862 TGR5 Signaling Protects Against Inflammatory Bowel Diseases Through Antagonizing NF-κB Signaling and Reactive Oxygen Species Generation

Farnesoid X receptor antagonizes NF-κB in hepatic inflammatory response

Activation of farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers

Farnesoid X Receptor Alleviates Age-Related Proliferation Defects in Regenerating Mouse Livers by Activating Forkhead Box mlb Transcription

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