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Comparison and optimization of hiPSC forebrain cortical differentiation protocols

PloS one, 2014-08, Vol.9 (8), p.e105807-e105807

2014

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APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly

Cell, 2014-07, Vol.158 (2), p.368-382

2014

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Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

Molecular neurodegeneration, 2023-11, Vol.18 (1), p.1-89, Article 89

2023

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Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia

Annals of neurology, 2018-07, Vol.84 (1), p.78-88

2018

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The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

Human molecular genetics, 2014-07, Vol.23 (13), p.3523-3536

2014

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Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model

Journal of neuroimaging, 2022-07, Vol.32 (4), p.617-628

2022

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Person‐specific differences in ubiquitin‐proteasome mediated proteostasis in human neurons

Alzheimer's & dementia, 2024-04, Vol.20 (4), p.2952-2967

2024

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PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

Acta neuropathologica, 2020-03, Vol.139 (3), p.503-526

2020

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Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

Cell reports (Cambridge), 2015-09, Vol.12 (9), p.1414-1429

2015

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Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain

Journal of extracellular vesicles, 2022-01, Vol.11 (1), p.e12183-n/a

2022

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Somatic mosaicism of sex chromosomes in the blood and brain

Brain research, 2019-10, Vol.1721, p.146345-146345, Article 146345

2019

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INPP5D regulates inflammasome activation in human microglia

Nature communications, 2023-11, Vol.14 (1), p.7552-23, Article 7552

2023

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Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing

Nature communications, 2023-11, Vol.14 (1), p.7575-7575, Article 7575

2023

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Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids

Translational psychiatry, 2018-04, Vol.8 (1), p.77-14, Article 77

2018

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Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

Neural development, 2008-06, Vol.3 (1), p.15-15, Article 15

2008

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Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

Molecular neurodegeneration, 2020-01, Vol.15 (1), p.3-8, Article 3

2020

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Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development

The Journal of neuroscience, 2010-08, Vol.30 (31), p.10431-10440

2010

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Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1

Cell reports (Cambridge), 2023-08, Vol.42 (8), p.112994-112994, Article 112994

2023

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Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer’s disease

Trends in neurosciences (Regular ed.), 2023-06, Vol.46 (6), p.426-444

2023

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Systematic Evaluation of Candidate Ligands Regulating Ectodomain Shedding of Amyloid Precursor Protein

Biochemistry (Easton), 2013-05, Vol.52 (19), p.3264-3277

2013

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A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

Nature neuroscience, 2018-06, Vol.21 (6), p.811-819

2018

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Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity

Molecular neurodegeneration, 2022-09, Vol.17 (1), p.61-23, Article 61

2022

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Mosaic loss of Chromosome Y in aged human microglia

Genome research, 2022-10, Vol.32 (10), p.1795

2022

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Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains

Nature neuroscience, 2019-01, Vol.22 (1), p.37-46

2019

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Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics

Acta neuropathologica communications, 2023-03, Vol.11 (1), p.39-20, Article 39

2023

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Comparison and optimization of hiPSC forebrain cortical differentiation protocols

APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model

Person‐specific differences in ubiquitin‐proteasome mediated proteostasis in human neurons

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain

Somatic mosaicism of sex chromosomes in the blood and brain

INPP5D regulates inflammasome activation in human microglia

Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development

Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1

Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer’s disease

Systematic Evaluation of Candidate Ligands Regulating Ectodomain Shedding of Amyloid Precursor Protein

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity

Mosaic loss of Chromosome Y in aged human microglia

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains

Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics

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