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Leveraging a physiologically-based quantitative translational modeling platform for designing B cell maturation antigen-targeting bispecific T cell engagers for treatment of multiple myeloma

PLoS computational biology, 2022-07, Vol.18 (7), p.e1009715-e1009715

2022

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Advanced translational PBPK model for transferrin receptor-mediated drug delivery to the brain

Journal of controlled release, 2023-05, Vol.357, p.379-393

2023

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Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice

Pharmaceutical research, 2020-08, Vol.37 (8), Article 164

2020

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising TAK-438 (Vonoprazan) Doses in Healthy Male Japanese/non-Japanese Subjects

Clinical and translational gastroenterology, 2015-06, Vol.6 (6), p.e94-e94

2015

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A validated simultaneous quantification method for vonoprazan (TAK-438F) and its 4 metabolites in human plasma by the liquid chromatography-tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016-03, Vol.1015-1016, p.42-49

2016

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A Citrulline‐Based Translational Population System Toxicology Model for Gastrointestinal‐Related Adverse Events Associated With Anticancer Treatments

CPT: pharmacometrics and systems pharmacology, 2019-12, Vol.8 (12), p.951-961

2019

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Chemical reactivity of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242) in vitro

Biopharmaceutics & drug disposition, 2011-10, Vol.32 (7), p.408-425

2011

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In vivo relationship between thalamic nicotinic acetylcholine receptor occupancy rates and antiallodynic effects in a rat model of neuropathic pain: Persistent agonist binding inhibits the expression of antiallodynic effects

Synapse (New York, N.Y.), 2011-01, Vol.65 (1), p.77-83

2011

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Studies on 1-alkylamine adduct formation in electrospray ionization mass spectrometry for quantitative analysis

Journal of pharmaceutical and biomedical analysis, 2008-08, Vol.47 (4), p.962-966

2008

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Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm

Clinical pharmacology and therapeutics, 2021-03, Vol.109 (3), p.605-618

2021

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Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model

Drug metabolism and disposition, 2022-07, Vol.50 (7), p.980-988

2022

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Phase 1a/1b study design of the novel STING agonist, immune-stimulating antibody-conjugate (ISAC) TAK-500, with or without pembrolizumab in patients with advanced solid tumors

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.TPS2690-TPS2690

2022

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Retrospective Data Analysis and Proposal of a Practical Acceptance Criterion for Inter-laboratory Cross-validation of Bioanalytical Methods Using Liquid Chromatography/Tandem Mass Spectrometry

The AAPS journal, 2014-11, Vol.16 (6), p.1226-1236

2014

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Abstract CT249: First-in-human study of TAK-500, a novel STING agonist immune stimulating antibody conjugate (ISAC), alone and in combination with pembrolizumab in patients with select advanced solid tumors

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.CT249-CT249

2022

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Abstract 1841: TAK-500 is a clinical stage immune-cell directed antibody drug conjugate (iADC) inducing STING activation in CCR2-expressing intratumor myeloid cells and favorable immunomodulation

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1841-1841

2023

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Chemical reactivity of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242) in vitro: CHEMICAL REACTIVITY OF TAK-242 IN VITRO

Biopharmaceutics & drug disposition, 2011-10, Vol.32 (7), p.408-425

2011

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Stereocontrolled Total Synthesis of (+)-Isolaurenidificin and (−)-Bromlaurenidificin

Journal of organic chemistry, 2019-12, Vol.84 (23), p.15549-15556

2019

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Madden–Julian Oscillation prediction skill of a new-generation global model demonstrated using a supercomputer

Nature communications, 2014-05, Vol.5 (1), p.3769-3769, Article 3769

2014

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Morphogenesis of the femur at different stages of normal human development

PloS one, 2019-08, Vol.14 (8), p.e0221569-e0221569

2019

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NNSVS: A Neural Network-Based Singing Voice Synthesis Toolkit

ICASSP 2023 - 2023 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2023, p.1-5

2023

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High-Fidelity and Pitch-Controllable Neural Vocoder Based on Unified Source-Filter Networks

IEEE/ACM transactions on audio, speech, and language processing, 2023, Vol.31, p.3717-3729

2023

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Visualization and Performance Evaluation of a Liquid-Ethanol Cylindrical Rotating Detonation Combustor

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, 2023, Vol.66(2), pp.46-58

2023

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Lung carcinogenicity by whole body inhalation exposure to Anatase-type Nano-titanium Dioxide in rats

The Journal of Toxicological Sciences, 2024, Vol.49(8), pp.359-383

2024

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The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus

Journal of Virology, 2005-04, Vol.79 (7), p.4460-4469

2005

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Contact stress and temperature during air-stamp hammer upsetting of a circular cylinder

Journal of manufacturing processes, 2018-04, Vol.32, p.791-801

2018

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Leveraging a physiologically-based quantitative translational modeling platform for designing B cell maturation antigen-targeting bispecific T cell engagers for treatment of multiple myeloma

Advanced translational PBPK model for transferrin receptor-mediated drug delivery to the brain

Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising TAK-438 (Vonoprazan) Doses in Healthy Male Japanese/non-Japanese Subjects

A validated simultaneous quantification method for vonoprazan (TAK-438F) and its 4 metabolites in human plasma by the liquid chromatography-tandem mass spectrometry

A Citrulline‐Based Translational Population System Toxicology Model for Gastrointestinal‐Related Adverse Events Associated With Anticancer Treatments

Chemical reactivity of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242) in vitro

In vivo relationship between thalamic nicotinic acetylcholine receptor occupancy rates and antiallodynic effects in a rat model of neuropathic pain: Persistent agonist binding inhibits the expression of antiallodynic effects

Studies on 1-alkylamine adduct formation in electrospray ionization mass spectrometry for quantitative analysis

Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm

Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model

Phase 1a/1b study design of the novel STING agonist, immune-stimulating antibody-conjugate (ISAC) TAK-500, with or without pembrolizumab in patients with advanced solid tumors

Retrospective Data Analysis and Proposal of a Practical Acceptance Criterion for Inter-laboratory Cross-validation of Bioanalytical Methods Using Liquid Chromatography/Tandem Mass Spectrometry

Abstract CT249: First-in-human study of TAK-500, a novel STING agonist immune stimulating antibody conjugate (ISAC), alone and in combination with pembrolizumab in patients with select advanced solid tumors

Abstract 1841: TAK-500 is a clinical stage immune-cell directed antibody drug conjugate (iADC) inducing STING activation in CCR2-expressing intratumor myeloid cells and favorable immunomodulation

Chemical reactivity of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242) in vitro: CHEMICAL REACTIVITY OF TAK-242 IN VITRO

Stereocontrolled Total Synthesis of (+)-Isolaurenidificin and (−)-Bromlaurenidificin

Madden–Julian Oscillation prediction skill of a new-generation global model demonstrated using a supercomputer

Morphogenesis of the femur at different stages of normal human development

NNSVS: A Neural Network-Based Singing Voice Synthesis Toolkit

High-Fidelity and Pitch-Controllable Neural Vocoder Based on Unified Source-Filter Networks

Visualization and Performance Evaluation of a Liquid-Ethanol Cylindrical Rotating Detonation Combustor

Lung carcinogenicity by whole body inhalation exposure to Anatase-type Nano-titanium Dioxide in rats

The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus

Contact stress and temperature during air-stamp hammer upsetting of a circular cylinder

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