UB Paderborn / Katalog / Suche / in CDI

Reprogramming of serine, glycine and one-carbon metabolism in cancer

Biochimica et biophysica acta. Molecular basis of disease, 2020-10, Vol.1866 (10), p.165841-165841, Article 165841

2020

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Quantitative flux analysis reveals folate-dependent NADPH production

Nature (London), 2014-06, Vol.510 (7504), p.298-302

2014

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p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

Cell reports (Cambridge), 2018-01, Vol.22 (3), p.569-575

2018

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GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

Genes & development, 2015-11, Vol.29 (22), p.2331-2336

2015

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Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (18), p.6904-6909

2012

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The magic bullet: Niclosamide

Frontiers in oncology, 2022-11, Vol.12, p.1004978-1004978

2022

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Serine catabolism regulates mitochondrial redox control during hypoxia

Cancer discovery, 2014-12, Vol.4 (12), p.1406-1417

2014

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ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis

Current molecular medicine, 2009-05, Vol.9 (4), p.411

2009

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The Warburg effect drives dedifferentiation through epigenetic reprogramming

Cancer biology & medicine, 2024-02, Vol.20 (12), p.891-897

2024

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Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia

Cell death & disease, 2020-02, Vol.11 (2), p.102, Article 102

2020

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Induction of sarcomas by mutant IDH2

Genes & development, 2013-09, Vol.27 (18), p.1986-1998

2013

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Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer

British journal of cancer, 2021-02, Vol.124 (3), p.604-615

2021

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Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies

Molecular therapy. Nucleic acids, 2023-06, Vol.32, p.13-27

2023

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Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state

Cell death & disease, 2024-01, Vol.15 (1), p.89-89, Article 89

2024

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Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways

Cancer research (Chicago, Ill.), 2008-11, Vol.68 (22), p.9323-9330

2008

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Modulation of CCAAT/Enhancer Binding Protein Homologous Protein (CHOP)-dependent DR5 Expression by Nelfinavir Sensitizes Glioblastoma Multiforme Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)

The Journal of biological chemistry, 2011-08, Vol.286 (33), p.29408-29416

2011

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Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

PLoS genetics, 2015-06, Vol.11 (6), p.e1005212-e1005212

2015

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The PHGDH enigma: Do cancer cells only need serine or also a redox modulator?

Cancer letters, 2020-04, Vol.476, p.97-105

2020

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Deciphering the Warburg Effect: Metabolic Reprogramming, Epigenetic Remodeling, and Cell Dedifferentiation

Annual review of cancer biology, 2024-06, Vol.8 (1), p.35-58

2024

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Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium

Journal of the American College of Cardiology, 2021-03, Vol.77 (8), p.1073-1088

2021

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NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function

Molecular therapy, 2022-04, Vol.30 (4), p.1421-1431

2022

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ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

Nature cell biology, 2019-07, Vol.21 (7), p.889

2019

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The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

The EMBO journal, 2010-06, Vol.29 (12), p.2082-2096

2010

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Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy

Science translational medicine, 2023-02, Vol.15 (683), p.eabq3558

2023

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PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy

Cell metabolism, 2023-03, Vol.35 (3), p.517-534.e8

2023

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Reprogramming of serine, glycine and one-carbon metabolism in cancer

Quantitative flux analysis reveals folate-dependent NADPH production

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

The magic bullet: Niclosamide

Serine catabolism regulates mitochondrial redox control during hypoxia

ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis

The Warburg effect drives dedifferentiation through epigenetic reprogramming

Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia

Induction of sarcomas by mutant IDH2

Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer

Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies

Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state

Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways

Modulation of CCAAT/Enhancer Binding Protein Homologous Protein (CHOP)-dependent DR5 Expression by Nelfinavir Sensitizes Glioblastoma Multiforme Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

The PHGDH enigma: Do cancer cells only need serine or also a redox modulator?

Deciphering the Warburg Effect: Metabolic Reprogramming, Epigenetic Remodeling, and Cell Dedifferentiation

Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium

NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy

PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy

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