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At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy

Journal of leukocyte biology, 2013-07, Vol.94 (1), p.25-39

2013

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L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

Nature chemical biology, 2017-05, Vol.13 (5), p.494

2017

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Hypoxia Induces Production of L-2-Hydroxyglutarate

Cell metabolism, 2015-08, Vol.22 (2), p.304-311

2015

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Precision therapy for lymphoma--current state and future directions

Nature reviews. Clinical oncology, 2014-10, Vol.11 (10), p.585-596

2014

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Induction of sarcomas by mutant IDH2

Genes & development, 2013-09, Vol.27 (18), p.1986-1998

2013

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Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A

Genes & development, 2009-07, Vol.23 (14), p.1665-1676

2009

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D-2HG comes out of its shell: Metabolic effects on the immune environment

Molecular cell, 2022-12, Vol.82 (23), p.4407-4409

2022

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From empiric to mechanism-based therapy for peripheral T cell lymphoma

International journal of hematology, 2014-03, Vol.99 (3), p.249-262

2014

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T cells critically depend on pyruvate oxidation

Cell metabolism, 2021-09, Vol.33 (9), p.1719-1720

2021

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Metabolic signatures of cancer cells and stem cells

Nature metabolism, 2019-02, Vol.1 (2), p.177-188

2019

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As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

Cell metabolism, 2018-02, Vol.27 (2), p.428-438.e5

2018

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The epigenomics of sarcoma

Nature reviews. Cancer, 2020-10, Vol.20 (10), p.608

2020

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In vivo library screening identifies the metabolic enzyme aldolase A as a promoter of metastatic lung colonization

iScience, 2021-05, Vol.24 (5), p.102425-102425, Article 102425

2021

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Phase II Trial of Pembrolizumab Plus Gemcitabine, Vinorelbine, and Liposomal Doxorubicin as Second-Line Therapy for Relapsed or Refractory Classical Hodgkin Lymphoma

Journal of clinical oncology, 2021-10, Vol.39 (28), p.3109-3117

2021

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Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche

The Journal of immunology (1950), 2010-11, Vol.185 (9), p.4988-4992

2010

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Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

Nature immunology, 2011-05, Vol.12 (7), p.663

2011

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A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

Immunity (Cambridge, Mass.), 2009-08, Vol.31 (2), p.309-320

2009

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Oncogenic Mechanisms and Therapeutic Targeting of Metabolism in Leukemia and Lymphoma

Cold Spring Harbor perspectives in biology, 2021-07, Vol.11 (7), p.a035477

2021

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Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

Nature (London), 2018-07, Vol.559 (7712), p.125-129

2018

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Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting

Blood, 2016-06, Vol.127 (24), p.3004-3014

2016

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Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2 - and TET2 -Mutant Acute Myeloid Leukemia

Cancer discovery, 2017-05, Vol.7 (5), p.494-505

2017

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Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics

Journal of proteome research, 2021-04, Vol.20 (4), p.1835-1848

2021

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FXR mediates T cell-intrinsic responses to reduced feeding during infection

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (52), p.33446-33454

2020

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At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

Hypoxia Induces Production of L-2-Hydroxyglutarate

Precision therapy for lymphoma--current state and future directions

Induction of sarcomas by mutant IDH2

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A

D-2HG comes out of its shell: Metabolic effects on the immune environment

From empiric to mechanism-based therapy for peripheral T cell lymphoma

T cells critically depend on pyruvate oxidation

Metabolic signatures of cancer cells and stem cells

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

The epigenomics of sarcoma

In vivo library screening identifies the metabolic enzyme aldolase A as a promoter of metastatic lung colonization

Phase II Trial of Pembrolizumab Plus Gemcitabine, Vinorelbine, and Liposomal Doxorubicin as Second-Line Therapy for Relapsed or Refractory Classical Hodgkin Lymphoma

Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

Oncogenic Mechanisms and Therapeutic Targeting of Metabolism in Leukemia and Lymphoma

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting

Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2 - and TET2 -Mutant Acute Myeloid Leukemia

Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics

FXR mediates T cell-intrinsic responses to reduced feeding during infection

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