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The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression

Molecular cancer therapeutics, 2018-08, Vol.17 (8), p.1670-1682

2018

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Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity

Clinical cancer research, 2016-10, Vol.22 (20), p.5130-5140

2016

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A meta-analysis of tumour response and relapse kinetics based on 34,881 patients: A question of cancer type, treatment and line of treatment

European journal of cancer (1990), 2021-06, Vol.150, p.42-52

2021

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Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

Cancer chemotherapy and pharmacology, 2016-07, Vol.78 (1), p.131-141

2016

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Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

Journal of pharmacy and pharmacology, 2017-10, Vol.69 (10), p.1275-1283

2017

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Modelling of tumour growth and cytotoxic effect of docetaxel in xenografts

Computer methods and programs in biomedicine, 2014-05, Vol.114 (3), p.e3-e13

2014

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Structural identifiability analysis via symmetries of differential equations

Automatica (Oxford), 2009-11, Vol.45 (11), p.2585-2591

2009

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Oxygen-Driven Tumour Growth Model: A Pathology-Relevant Mathematical Approach: e1004550

PLoS computational biology, 2015-10, Vol.11 (10)

2015

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Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats

Integrative biology, 2013-01, Vol.5 (6), p.877-888

2013

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Determination of the safety and efficacy of therapeutic neutralization of tumor necrosis factor-α (TNF-α) using AZD9773, an anti-TNF-α immune Fab, in murine CLP sepsis

Inflammation research, 2014-02, Vol.63 (2), p.149-160

2014

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Estimating insulin sensitivity from glucose levels only: Use of a non-linear mixed effects approach and maximum a posteriori (MAP) estimation

Computer methods and programs in biomedicine, 2013-02, Vol.109 (2), p.134-143

2013

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Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake

Computer methods and programs in biomedicine, 2014-05, Vol.114 (3), p.e60-e69

2014

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Abstract 4524: A preclinical PKPD modeling & simulation strategy: building a predictive model of dose, schedule and therapeutic index for small molecule targeted anticancer agents

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.4524-4524

2015

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Population pharmacokinetic/pharmacodynamic modelling of the anti-TNF-α polyclonal fragment antibody AZD9773 in patients with severe sepsis

Journal of pharmacokinetics and pharmacodynamics, 2012-12, Vol.39 (6), p.591-599

2012

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An implementation of the Expectation-Maximisation (EM) algorithm for population pharmacokinetic–pharmacodynamic modelling in ACSLXTREME

Computer methods and programs in biomedicine, 2009-10, Vol.96 (1), p.49-62

Yates, James W.T

2009

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Structural identifiability and indistinguishability of compartmental models

Expert opinion on drug metabolism & toxicology, 2009-03, Vol.5 (3), p.295-302

2009

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The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression

Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity

A meta-analysis of tumour response and relapse kinetics based on 34,881 patients: A question of cancer type, treatment and line of treatment

Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

Modelling of tumour growth and cytotoxic effect of docetaxel in xenografts

Structural identifiability analysis via symmetries of differential equations

Oxygen-Driven Tumour Growth Model: A Pathology-Relevant Mathematical Approach: e1004550

Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats

Determination of the safety and efficacy of therapeutic neutralization of tumor necrosis factor-α (TNF-α) using AZD9773, an anti-TNF-α immune Fab, in murine CLP sepsis

Estimating insulin sensitivity from glucose levels only: Use of a non-linear mixed effects approach and maximum a posteriori (MAP) estimation

Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake

Abstract 4524: A preclinical PKPD modeling & simulation strategy: building a predictive model of dose, schedule and therapeutic index for small molecule targeted anticancer agents

Population pharmacokinetic/pharmacodynamic modelling of the anti-TNF-α polyclonal fragment antibody AZD9773 in patients with severe sepsis

An implementation of the Expectation-Maximisation (EM) algorithm for population pharmacokinetic–pharmacodynamic modelling in ACSLXTREME

Structural identifiability and indistinguishability of compartmental models

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