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Free Drug Theory – No Longer Just a Hypothesis?

Pharmaceutical research, 2022-02, Vol.39 (2), p.213-222

2022

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Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.9889-9907

2018

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The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression

Molecular cancer therapeutics, 2018-08, Vol.17 (8), p.1670-1682

2018

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Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity

Clinical cancer research, 2016-10, Vol.22 (20), p.5130-5140

2016

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4090-4110

2011

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Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader

Drug metabolism and disposition, 2018-09, Vol.46 (9), p.1268-1276

2018

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Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

Cancer chemotherapy and pharmacology, 2016-07, Vol.78 (1), p.131-141

2016

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PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4127-4157

2011

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Relationship of Physical Fitness Measures vs. Occupational Physical Ability in Campus Law Enforcement Officers

Journal of strength and conditioning research, 2015-08, Vol.29 (8), p.2340-2350

2015

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Skipping a pillar does not make for strong foundations: Pharmacokinetic‐pharmacodynamic reasoning behind the shape of dose–response relationships in oncology

CPT: pharmacometrics and systems pharmacology, 2023-11, Vol.12 (11), p.1591-1601

2023

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4074-4089

2011

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How translational modeling in oncology needs to get the mechanism just right

Clinical and translational science, 2022-03, Vol.15 (3), p.588-600

2022

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Comparison of classical tumour growth models for patient derived and cell-line derived xenografts using the nonlinear mixed-effects framework

Journal of biological dynamics, 2022-12, Vol.16 (1), p.160-185

2022

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Validation of a predictive modeling approach to demonstrate the relative efficacy of three different schedules of the AKT inhibitor AZD5363

Cancer chemotherapy and pharmacology, 2015-08, Vol.76 (2), p.343-356

2015

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Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

Journal of pharmacy and pharmacology, 2017-10, Vol.69 (10), p.1275-1283

2017

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Osimertinib for Patients With Leptomeningeal Metastases Associated With EGFR T790M-Positive Advanced NSCLC: The AURA Leptomeningeal Metastases Analysis

Journal of thoracic oncology, 2020-04, Vol.15 (4), p.637-648

2020

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Epstein-Barr Virus Reactivation After Paediatric Haematopoietic Stem Cell Transplantation: Risk Factors and Sensitivity Analysis of Mathematical Model

Frontiers in immunology, 2022-07, Vol.13, p.903063

2022

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4111-4126

2011

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Step‐by‐step comparison of ordinary differential equation and agent‐based approaches to pharmacokinetic‐pharmacodynamic models

CPT: pharmacometrics and systems pharmacology, 2022-02, Vol.11 (2), p.133-148

2022

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PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 1: Goals, Properties of the Phrma Dataset, and Comparison with Literature Datasets

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4050-4073

2011

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Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network

CPT: pharmacometrics and systems pharmacology, 2019-05, Vol.8 (5), p.259-272

2019

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Oxygen-Driven Tumour Growth Model: A Pathology-Relevant Mathematical Approach

PLoS computational biology, 2015-10, Vol.11 (10), p.e1004550-e1004550

2015

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The ingredients for an antimicrobial mathematical modelling broth

International journal of antimicrobial agents, 2022-10, Vol.60 (4), p.106641-106641, Article 106641

2022

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Modelling of tumour growth and cytotoxic effect of docetaxel in xenografts

Computer methods and programs in biomedicine, 2014-05, Vol.114 (3), p.e3-e13

2014

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Free Drug Theory – No Longer Just a Hypothesis?

Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression

Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance

Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader

Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Relationship of Physical Fitness Measures vs. Occupational Physical Ability in Campus Law Enforcement Officers

Skipping a pillar does not make for strong foundations: Pharmacokinetic‐pharmacodynamic reasoning behind the shape of dose–response relationships in oncology

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution

How translational modeling in oncology needs to get the mechanism just right

Comparison of classical tumour growth models for patient derived and cell-line derived xenografts using the nonlinear mixed-effects framework

Validation of a predictive modeling approach to demonstrate the relative efficacy of three different schedules of the AKT inhibitor AZD5363

Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

Osimertinib for Patients With Leptomeningeal Metastases Associated With EGFR T790M-Positive Advanced NSCLC: The AURA Leptomeningeal Metastases Analysis

Epstein-Barr Virus Reactivation After Paediatric Haematopoietic Stem Cell Transplantation: Risk Factors and Sensitivity Analysis of Mathematical Model

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach

Step‐by‐step comparison of ordinary differential equation and agent‐based approaches to pharmacokinetic‐pharmacodynamic models

PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 1: Goals, Properties of the Phrma Dataset, and Comparison with Literature Datasets

Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network

Oxygen-Driven Tumour Growth Model: A Pathology-Relevant Mathematical Approach

The ingredients for an antimicrobial mathematical modelling broth

Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs

Modelling of tumour growth and cytotoxic effect of docetaxel in xenografts

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