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Free Drug Theory – No Longer Just a Hypothesis?

Pharmaceutical research, 2022-02, Vol.39 (2), p.213-222

2022

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Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.9889-9907

2018

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Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity

Clinical cancer research, 2016-10, Vol.22 (20), p.5130-5140

2016

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The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression

Molecular cancer therapeutics, 2018-08, Vol.17 (8), p.1670-1682

2018

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Osimertinib for Patients With Leptomeningeal Metastases Associated With EGFR T790M-Positive Advanced NSCLC: The AURA Leptomeningeal Metastases Analysis

Journal of thoracic oncology, 2020-04, Vol.15 (4), p.637-648

2020

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Skipping a pillar does not make for strong foundations: Pharmacokinetic‐pharmacodynamic reasoning behind the shape of dose–response relationships in oncology

CPT: pharmacometrics and systems pharmacology, 2023-11, Vol.12 (11), p.1591-1601

2023

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Ecology, Not Host Phylogeny, Shapes the Oral Microbiome in Closely Related Species

Molecular biology and evolution, 2022-12, Vol.39 (12)

2022

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4090-4110

2011

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A Robust Framework for Microbial Archaeology

Annual review of genomics and human genetics, 2017-08, Vol.18 (1), p.321-356

2017

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PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4127-4157

2011

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The ingredients for an antimicrobial mathematical modelling broth

International journal of antimicrobial agents, 2022-10, Vol.60 (4), p.106641-106641, Article 106641

2022

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AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules

Molecular cancer therapeutics, 2015-11, Vol.14 (11), p.2508-2518

2015

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Differential preservation of endogenous human and microbial DNA in dental calculus and dentin

Scientific reports, 2018-06, Vol.8 (1), p.9822-15, Article 9822

2018

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Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

Cancer chemotherapy and pharmacology, 2016-07, Vol.78 (1), p.131-141

2016

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In situ solid-state nanopore fabrication

Chemical Society reviews, 2021-04, Vol.50 (8), p.4974-4992

2021

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Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader

Drug metabolism and disposition, 2018-09, Vol.46 (9), p.1268-1276

2018

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Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage

Microbiome, 2019-07, Vol.7 (1), p.102-102, Article 102

2019

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Identifying and characterising the impact of excitability in a mathematical model of tumour-immune interactions

Journal of theoretical biology, 2020-09, Vol.501, p.110250-110250, Article 110250

2020

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Quantifying Preexisting Resistant and Persister Populations-Letter

Cancer research (Chicago, Ill.), 2019-10, Vol.79 (19), p.5121-5121

2019

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A meta-analysis of tumour response and relapse kinetics based on 34,881 patients: A question of cancer type, treatment and line of treatment

European journal of cancer (1990), 2021-06, Vol.150, p.42-52

2021

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How translational modeling in oncology needs to get the mechanism just right

Clinical and translational science, 2022-03, Vol.15 (3), p.588-600

2022

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Reproducible, portable, and efficient ancient genome reconstruction with nf-core/eager

PeerJ (San Francisco, CA), 2021-03, Vol.9, p.e10947-e10947, Article e10947

2021

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Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic

Science (American Association for the Advancement of Science), 2023-05, Vol.380 (6645), p.619-624

2023

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4074-4089

2011

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Free Drug Theory – No Longer Just a Hypothesis?

Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity

The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression

Osimertinib for Patients With Leptomeningeal Metastases Associated With EGFR T790M-Positive Advanced NSCLC: The AURA Leptomeningeal Metastases Analysis

Skipping a pillar does not make for strong foundations: Pharmacokinetic‐pharmacodynamic reasoning behind the shape of dose–response relationships in oncology

Ecology, Not Host Phylogeny, Shapes the Oral Microbiome in Closely Related Species

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance

A Robust Framework for Microbial Archaeology

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

The ingredients for an antimicrobial mathematical modelling broth

AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules

Differential preservation of endogenous human and microbial DNA in dental calculus and dentin

Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

In situ solid-state nanopore fabrication

Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader

Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage

Identifying and characterising the impact of excitability in a mathematical model of tumour-immune interactions

Quantifying Preexisting Resistant and Persister Populations-Letter

A meta-analysis of tumour response and relapse kinetics based on 34,881 patients: A question of cancer type, treatment and line of treatment

How translational modeling in oncology needs to get the mechanism just right

Reproducible, portable, and efficient ancient genome reconstruction with nf-core/eager

Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution

Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs

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