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PyClone: statistical inference of clonal population structure in cancer

Nature methods, 2014-04, Vol.11 (4), p.396-398

2014

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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

Blood, 2011-02, Vol.117 (8), p.2451-2459

2011

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Clonal genotype and population structure inference from single-cell tumor sequencing

Nature methods, 2016-07, Vol.13 (7), p.573-576

2016

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Mll5 is required for normal spermatogenesis

PloS one, 2011-11, Vol.6 (11), p.e27127-e27127

2011

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The Oncogenic Roles of DICER1 RNase IIIb Domain Mutations in Ovarian Sertoli-Leydig Cell Tumors

Neoplasia (New York, N.Y.), 2015-08, Vol.17 (8), p.650-660

2015

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Accurate determination of CRISPR-mediated gene fitness in transplantable tumours

Nature communications, 2022-08, Vol.13 (1), p.4534-4534, Article 4534

2022

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Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro

Human mutation, 2016-03, Vol.37 (3), p.301-307

2016

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A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

Blood, 2014-06, Vol.123 (25), p.3914-3924

2014

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Solution NMR structure and histone binding of the PHD domain of human MLL5

PloS one, 2013-10, Vol.8 (10), p.e77020-e77020

2013

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Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia

Haematologica (Roma), 2014-09, Vol.99 (9), p.1456-1464

2014

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Mutation at Ser392 specifically sensitizes mutant p53H175 to mdm2-mediated degradation

Cell cycle (Georgetown, Tex.), 2010-04, Vol.9 (7), p.1390-1398

2010

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Atrophin controls developmental signaling pathways via interactions with Trithorax-like

eLife, 2017-03, Vol.6, p.1

2017

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mdm2 : a bridge over the two tumour suppressors, p53 and Rb: p53

Oncogene, 1999-12, Vol.18 (53), p.7681-7689

1999

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Novel Function of the Cyclin A Binding Site of E2F in Regulating p53-Induced Apoptosis in Response to DNA Damage

Molecular and Cellular Biology, 2002-01, Vol.22 (1), p.78-93

2002

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The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

BMC genomics, 2011-04, Vol.12 (1), p.209-209, Article 209

2011

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TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

Genome research, 2014-11, Vol.24 (11), p.1881-1893

2014

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The clonal and mutational evolution spectrum of primary triple―negative breast cancers

Nature (London), 2012-06, Vol.486 (7403), p.395-399

2012

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Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation

Blood, 2009-02, Vol.113 (7), p.1432-1443

2009

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Single-cell genomic variation induced by mutational processes in cancer

Nature (London), 2022-12, Vol.612 (7938), p.106-115

2022

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The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type

The Journal of pathology, 2017-07, Vol.242 (3), p.371-383

2017

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Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies

Nature communications, 2022-06, Vol.13 (1), p.3607-3607, Article 3607

2022

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Ser392 phosphorylation regulates the oncogenic function of mutant p53

Cancer research (Chicago, Ill.), 2004-07, Vol.64 (14), p.4749-4754

2004

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Does age influence the intrinsic biology of breast cancer?

Journal of clinical oncology, 2015-05, Vol.33 (15_suppl), p.11044-11044

2015

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PyClone: statistical inference of clonal population structure in cancer

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

Clonal genotype and population structure inference from single-cell tumor sequencing

Mll5 is required for normal spermatogenesis

The Oncogenic Roles of DICER1 RNase IIIb Domain Mutations in Ovarian Sertoli-Leydig Cell Tumors

Accurate determination of CRISPR-mediated gene fitness in transplantable tumours

Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

Solution NMR structure and histone binding of the PHD domain of human MLL5

Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia

Mutation at Ser392 specifically sensitizes mutant p53H175 to mdm2-mediated degradation

Atrophin controls developmental signaling pathways via interactions with Trithorax-like

mdm2 : a bridge over the two tumour suppressors, p53 and Rb: p53

Novel Function of the Cyclin A Binding Site of E2F in Regulating p53-Induced Apoptosis in Response to DNA Damage

The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

The clonal and mutational evolution spectrum of primary triple―negative breast cancers

Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation

Single-cell genomic variation induced by mutational processes in cancer

The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type

Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies

Ser392 phosphorylation regulates the oncogenic function of mutant p53

Does age influence the intrinsic biology of breast cancer?

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

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