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Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome

Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (28), p.14154-14163

2019

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A quinazoline‐based bromodomain inhibitor, CN210, ameliorates indomethacin‐induced ileitis in mice by inhibiting inflammatory cytokine expression

Drug development research, 2021-12, Vol.82 (8), p.1235-1246

2021

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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

Journal of medicinal chemistry, 2017-11, Vol.60 (22), p.9184-9204

2017

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CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia

Biochemical and biophysical research communications, 2022-01, Vol.590, p.49-54

2022

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A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase

Scientific reports, 2018-06, Vol.8 (1), p.9472-16, Article 9472

2018

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Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

eLife, 2018-11, Vol.7 (11, 2018)

2018

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A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

PloS one, 2017-01, Vol.12 (1), p.e0170937-e0170937

2017

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Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases

Bioorganic & medicinal chemistry letters, 2019-05, Vol.29 (10), p.1220-1226

2019

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Discovery and lead identification of quinazoline-based BRD4 inhibitors

Bioorganic & medicinal chemistry letters, 2018-11, Vol.28 (21), p.3483-3488

2018

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Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4

Molecular cancer therapeutics, 2019-02, Vol.18 (2), p.421-436

2019

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ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression

NPJ precision oncology, 2023-07, Vol.7 (1), p.66-66, Article 66

2023

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Total Synthesis of (+)-Brasilenyne. Application of an Intramolecular Silicon-Assisted Cross-Coupling Reaction

Journal of the American Chemical Society, 2004-10, Vol.126 (39), p.12432-12440

2004

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A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

PloS one, 2016-08, Vol.11 (8), p.e0161486-e0161486

2016

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Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity

Journal of medicinal chemistry, 2018-06, Vol.61 (11), p.4883-4903

2018

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Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma

Brain (London, England : 1878), 2023-04, Vol.146 (4), p.1697-1713

2023

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Retro Drug Design: From Target Properties to Molecular Structures

Journal of chemical information and modeling, 2022-06, Vol.62 (11), p.2659-2669

2022

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Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.5967-5978

2015

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Intramolecular Silicon-Assisted Cross-Coupling: Total Synthesis of (+)-Brasilenyne

Journal of the American Chemical Society, 2002-12, Vol.124 (51), p.15196-15197

2002

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Intramolecular Silicon-Assisted Cross-Coupling Reactions: General Synthesis of Medium-Sized Rings Containing a 1,3-cis-cis Diene Unit

Journal of the American Chemical Society, 2002-03, Vol.124 (10), p.2102-2103

2002

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Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.10984-11011

2020

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DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1

Cell death & disease, 2018-05, Vol.9 (5), p.561-15, Article 561

2018

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Sequential Ring-Closing Metathesis and Silicon-Assisted Cross-Coupling Reactions: Stereocontrolled Synthesis of Highly Substituted Unsaturated Alcohols

Organic letters, 2001-05, Vol.3 (11), p.1749-1752

2001

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A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome

Cell reports (Cambridge), 2021-04, Vol.35 (4), p.109040-109040, Article 109040

2021

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A Genome-Edited ERα-HiBiT Fusion Reporter Cell Line for the Identification of ERα Modulators Via High-Throughput Screening and CETSA

Assay and drug development technologies, 2021-12, Vol.19 (8), p.539-549

2021

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Synthesis of β‑Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones

Journal of organic chemistry, 2016-04, Vol.81 (8), p.3464-3469

2016

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Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome

A quinazoline‐based bromodomain inhibitor, CN210, ameliorates indomethacin‐induced ileitis in mice by inhibiting inflammatory cytokine expression

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases

Discovery and lead identification of quinazoline-based BRD4 inhibitors

Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4

ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression

Total Synthesis of (+)-Brasilenyne. Application of an Intramolecular Silicon-Assisted Cross-Coupling Reaction

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity

Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma

Retro Drug Design: From Target Properties to Molecular Structures

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

Intramolecular Silicon-Assisted Cross-Coupling: Total Synthesis of (+)-Brasilenyne

Intramolecular Silicon-Assisted Cross-Coupling Reactions: General Synthesis of Medium-Sized Rings Containing a 1,3-cis-cis Diene Unit

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1

Sequential Ring-Closing Metathesis and Silicon-Assisted Cross-Coupling Reactions: Stereocontrolled Synthesis of Highly Substituted Unsaturated Alcohols

A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome

A Genome-Edited ERα-HiBiT Fusion Reporter Cell Line for the Identification of ERα Modulators Via High-Throughput Screening and CETSA

Synthesis of β‑Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones

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