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Design of Selective, ATP-Competitive Inhibitors of Akt

Journal of medicinal chemistry, 2010-06, Vol.53 (12), p.4615-4622

2010

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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.650-665

2018

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Preparation of enantiomerically pure protected 4-oxo .alpha.-amino acids and 3-aryl .alpha.-amino acids from serine

Journal of organic chemistry, 1992-06, Vol.57 (12), p.3397-3404

1992

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Synthesis of Macrocyclic, Potential Protease Inhibitors Using a Generic Scaffold

Journal of organic chemistry, 2002-07, Vol.67 (14), p.4882-4892

2002

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A New Approach to the Synthesis of .beta.-Hydroxy-.alpha.-amino Acids Using (Arylthio)nitrooxiranes

Journal of organic chemistry, 1995-10, Vol.60 (20), p.6431-6440

1995

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Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.7669-7683

2019

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Abstract 1160: SAM competitive PRMT5 inhibitor PF06939999 demonstrates antitumor activity in splicing dysregulated NSCLC with decreased liability of drug resistance

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1160-1160

2021

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Abstract 3518: Growth inhibition of SCLC cell lines by treatment with LSD1 inhibitors is associated with modulation of neuroendocrine pathways

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.3518-3518

2015

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Abstract 4857: Discovery of PF-06855800, a SAM competitive PRMT5 inhibitor with potent antitumor activity

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4857-4857

2018

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Abstract 4863: PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4863-4863

2016

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Corrections to Design of Selective, ATP-Competitive Inhibitors of Akt

Journal of medicinal chemistry, 2010-08, Vol.53 (15), p.5895-5895

2010

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2-(6-Bromo-3-pyridyl)-8-methylimidazo[1,2- a ]pyrazine

Acta crystallographica. Section E, Structure reports online, 2010-07, Vol.66 (7), p.o1723-o1723

2010

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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)‑5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)‑one (PF-06821497)

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.650-665

2018

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An improved synthesis of the unique anti-migraine agent CP-122,288: A bromine atom passenger in an intramolecular Heck reaction

Tetrahedron letters, 1996-06, Vol.37 (25), p.4289-4292

1996

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A new direct method for the synthesis of enantiomerically pure protected α-amino acids

Journal of the Chemical Society. Chemical communications, 1989 (10), p.644-645

1989

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Synthesis of enantiomerically pure protected β-aryl alanines

Tetrahedron letters, 1989, Vol.30 (43), p.5941-5944

1989

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Preparation of a Serine-Derived Organozinc Reagent in Tetrahydrofuran: Synthesis of Novel, Enantiomerically Pure Allenic, Acetylenic and Heteroaryl Amino Acids

Synlett, 1993-07, Vol.1993 (7), p.499-500

1993

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An Approach to the Synthesis of Enantiomerically Pure Hydroxylated α-Amino Acids Using Zinc Homoenolate Chemistry

Synlett, 1990-12, Vol.1990 (12), p.735-736

1990

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Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Design of Selective, ATP-Competitive Inhibitors of Akt

Preparation of enantiomerically pure protected 4-oxo .alpha.-amino acids and 3-aryl .alpha.-amino acids from serine

Synthesis of Macrocyclic, Potential Protease Inhibitors Using a Generic Scaffold

SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance

A New Approach to the Synthesis of .beta.-Hydroxy-.alpha.-amino Acids Using (Arylthio)nitrooxiranes

Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase

Abstract 1160: SAM competitive PRMT5 inhibitor PF06939999 demonstrates antitumor activity in splicing dysregulated NSCLC with decreased liability of drug resistance

Abstract 3518: Growth inhibition of SCLC cell lines by treatment with LSD1 inhibitors is associated with modulation of neuroendocrine pathways

Abstract 4857: Discovery of PF-06855800, a SAM competitive PRMT5 inhibitor with potent antitumor activity

Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Abstract 4863: PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors

Corrections to Design of Selective, ATP-Competitive Inhibitors of Akt

2-(6-Bromo-3-pyridyl)-8-methylimidazo[1,2- a ]pyrazine

An improved synthesis of the unique anti-migraine agent CP-122,288: A bromine atom passenger in an intramolecular Heck reaction

A new direct method for the synthesis of enantiomerically pure protected α-amino acids

Synthesis of enantiomerically pure protected β-aryl alanines

Preparation of a Serine-Derived Organozinc Reagent in Tetrahydrofuran: Synthesis of Novel, Enantiomerically Pure Allenic, Acetylenic and Heteroaryl Amino Acids

An Approach to the Synthesis of Enantiomerically Pure Hydroxylated α-Amino Acids Using Zinc Homoenolate Chemistry

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