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MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery

Journal of medicinal chemistry, 2024-02, Vol.67 (3), p.2118-2128

2024

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Safety screening in early drug discovery: An optimized assay panel

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106609-106609, Article 106609

2019

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Correction to “MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery”

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.5111-5112

2024

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Integrated and automated high-throughput purification of libraries on microscale

SLAS technology, 2022-12, Vol.27 (6), p.350-360

2022

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Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease

The Journal of pharmacology and experimental therapeutics, 2017-09, Vol.362 (3), p.413-423

2017

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"Der Leistungsgedanke steht im Vordergrund" : Gespräch mit ddem Sportlerschulleiter René Wyler

Appenzellische Jahrbücher, 2019, Vol.146, p.117

Wyler, René

2019

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Lead Generation: Sowing the Seeds for Future Success

Chimia, 2004-09, Vol.58 (9), p.588

2004

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Synthesis of a Phosphonic Acid Analogue of N-Acetyl-2,3-didehydro-2-deoxyneuraminic Acid, an Inhibitor of Vibrio cholerae Sialidase

Helvetica chimica acta, 1991-03, Vol.74 (2), p.451-463

1991

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Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease

Alzheimer's & dementia, 2013-07, Vol.9 (4), p.P818-P818

2013

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P4–312: Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease

Alzheimer's & dementia, 2013-07, Vol.9 (4S_Part_21), p.P818-P818

2013

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1-Benzyloxy-4,5-dihydro- 1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3155-3159

2003

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2-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (5), p.829-832

2003

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4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

Bioorganic & medicinal chemistry letters, 2002-09, Vol.12 (18), p.2615-2619

2002

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4-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1 H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (10), p.1759-1762

2003

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Reversal of a Vigilance Decrement in the Aged Rat by Subtype-Selective Nicotinic Ligands

Neuropsychopharmacology, 2003-05, Vol.28 (5), p.880-887

2003

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A Synthetic Cavity Assembles Through Self-Complementary Hydrogen Bonds

Angewandte Chemie (International ed.), 1993-12, Vol.32 (12), p.1699-1701

1993

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Discovery of ( R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist

Bioorganic & medicinal chemistry letters, 2001-08, Vol.11 (16), p.2173-2176

2001

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Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease

The Journal of pharmacology and experimental therapeutics, 2017-09, Vol.362 (3), p.413

2017

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2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists

Chimia, 2004-01, Vol.58 (9), p.630

2004

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Bildung eines Hohlraums durch Dimerisierung selbstkomplementärer Moleküle über Wasserstoffbrückenbindungen

Angewandte Chemie, 1993-12, Vol.105 (12), p.1820-1821

1993

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Synthesis of the 6-C-Methyl and 6-C-(Hydroxymethyl) Analogues of N-Acetylneuraminic Acid and of N-Acetyl-2,3-didehydro-2-deoxyneuraminic Acid

Helvetica chimica acta, 1990-09, Vol.73 (6), p.1742-1763

1990

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A synthesis of N-acetylneuraminic acid and [6- 2H]- N-acetyl-neuraminic acid from N-acetyl- d-glucosamine

Carbohydrate research, 1987-07, Vol.164, p.415-432

1987

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Synthesis and Rearrangement of 6H-Imidazo[1,2-c]quinazolin-5-ones

Heterocycles, 1996, Vol.43 (12), p.2607

1996

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Replication and assembly

Pure and applied chemistry, 1993-01, Vol.65 (11), p.2313-2318

1993

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Bildung eines Hohlraums durch Dimerisierung selbstkomplementärer Moleküle über Wasserstoffbrückenbindungen

Angewandte Chemie, 1993, Vol.105 (12), p.1820-1821

1993

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MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery

Safety screening in early drug discovery: An optimized assay panel

Correction to “MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery”

Integrated and automated high-throughput purification of libraries on microscale

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease

"Der Leistungsgedanke steht im Vordergrund" : Gespräch mit ddem Sportlerschulleiter René Wyler

Lead Generation: Sowing the Seeds for Future Success

Synthesis of a Phosphonic Acid Analogue of N-Acetyl-2,3-didehydro-2-deoxyneuraminic Acid, an Inhibitor of Vibrio cholerae Sialidase

Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease

P4–312: Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease

1-Benzyloxy-4,5-dihydro- 1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

2-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

4-(3,4-Dihydro-1 H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1 H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists

Reversal of a Vigilance Decrement in the Aged Rat by Subtype-Selective Nicotinic Ligands

A Synthetic Cavity Assembles Through Self-Complementary Hydrogen Bonds

Discovery of ( R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease

2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists

Bildung eines Hohlraums durch Dimerisierung selbstkomplementärer Moleküle über Wasserstoffbrückenbindungen

Synthesis of the 6-C-Methyl and 6-C-(Hydroxymethyl) Analogues of N-Acetylneuraminic Acid and of N-Acetyl-2,3-didehydro-2-deoxyneuraminic Acid

A synthesis of N-acetylneuraminic acid and [6- 2H]- N-acetyl-neuraminic acid from N-acetyl- d-glucosamine

Synthesis and Rearrangement of 6H-Imidazo[1,2-c]quinazolin-5-ones

Replication and assembly

Bildung eines Hohlraums durch Dimerisierung selbstkomplementärer Moleküle über Wasserstoffbrückenbindungen

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