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Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention

PLoS pathogens, 2015-10, Vol.11 (10), p.e1005220-e1005220

2015

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Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses

Journal of virology, 2014-07, Vol.88 (13), p.7294-7306

2014

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Compound FC-10696 Inhibits Egress of Marburg Virus

Antimicrobial agents and chemotherapy, 2021-06, Vol.65 (7), p.e0008621-e0008621

2021

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Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

Journal of medicinal chemistry, 2008-03, Vol.51 (6), p.1861-1873

2008

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Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (15), p.3429-3435

2016

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Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor

Viruses, 2022-09, Vol.14 (9), p.2025

2022

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In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation

Molecular pharmacology, 2011-07, Vol.80 (1), p.124-135

2011

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A method for C2 acylation of 1,3-indandiones

Tetrahedron, 2018-05, Vol.74 (22), p.2762-2768

2018

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Tight-Binding Hydroxypyrazole HIV‑1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC‑I Downregulation

ACS infectious diseases, 2020-02, Vol.6 (2), p.302-312

2020

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Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists

Bioorganic & medicinal chemistry letters, 2016-03, Vol.26 (5), p.1480-1484

2016

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Dipeptide Prodrugs of the Glutamate Modulator Riluzole

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.752-756

2018

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LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse[S]

Journal of lipid research, 2009-12, Vol.50 (12), p.2358-2370

2009

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Intramolecular rearrangement of α-amino acid amide derivatives of 2-aminobenzothiazoles

Tetrahedron letters, 2014-07, Vol.55 (30), p.4193-4195

2014

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Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.378-383

2015

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Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1774-1787

2010

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Identification of Phenylsulfone-Substituted Quinoxaline (WYE-672) as a Tissue Selective Liver X-receptor (LXR) Agonist

Journal of medicinal chemistry, 2010-04, Vol.53 (8), p.3296-3304

2010

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Riluzole prodrugs for melanoma and ALS: Design, synthesis, and in vitro metabolic profiling

Bioorganic & medicinal chemistry, 2012-09, Vol.20 (18), p.5642-5648

2012

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Synthesis and Structure−Activity Relationship of Novel 6-Aryl-1,4- dihydrobenzo[d][1,3]oxazine-2-thiones as Progesterone Receptor Modulators Leading to the Potent and Selective Nonsteroidal Progesterone Receptor Agonist Tanaproget

Journal of medicinal chemistry, 2005-08, Vol.48 (16), p.5092-5095

2005

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Molecular and Pharmacological Properties of a Potent and Selective Novel Nonsteroidal Progesterone Receptor Agonist Tanaproget

The Journal of biological chemistry, 2005-08, Vol.280 (31), p.28468-28475

2005

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(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A Wingless β-Catenin Agonist That Increases Bone Formation Rate

Journal of medicinal chemistry, 2009-11, Vol.52 (22), p.6962-6965

2009

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Discovery of Phenyl Acetic Acid Substituted Quinolines as Novel Liver X Receptor Agonists for the Treatment of Atherosclerosis

Journal of medicinal chemistry, 2006-10, Vol.49 (21), p.6151-6154

2006

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Pyrrole[2,3- d]azepino compounds as agonists of the farnesoid X receptor (FXR)

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5289-5292

2009

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SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[ d][1,3]oxazin-2-ones as progesterone receptor antagonists

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.189-192

2007

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Novel 6-aryl-1,4-dihydrobenzo[ d] [1,3]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1313-1316

2003

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PTP1B Inhibition and Antihyperglycemic Activity in the ob/ob Mouse Model of Novel 11-Arylbenzo[b]naphtho[2,3-d]furans and 11-Arylbenzo[b]naphtho[2,3-d]thiophenes

Journal of medicinal chemistry, 1999-08, Vol.42 (17), p.3199-3202

1999

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Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention

Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses

Compound FC-10696 Inhibits Egress of Marburg Virus

Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress

Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor

In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation

A method for C2 acylation of 1,3-indandiones

Tight-Binding Hydroxypyrazole HIV‑1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC‑I Downregulation

Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists

Dipeptide Prodrugs of the Glutamate Modulator Riluzole

LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse[S]

Intramolecular rearrangement of α-amino acid amide derivatives of 2-aminobenzothiazoles

Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents

Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates

Identification of Phenylsulfone-Substituted Quinoxaline (WYE-672) as a Tissue Selective Liver X-receptor (LXR) Agonist

Riluzole prodrugs for melanoma and ALS: Design, synthesis, and in vitro metabolic profiling

Synthesis and Structure−Activity Relationship of Novel 6-Aryl-1,4- dihydrobenzo[d][1,3]oxazine-2-thiones as Progesterone Receptor Modulators Leading to the Potent and Selective Nonsteroidal Progesterone Receptor Agonist Tanaproget

Molecular and Pharmacological Properties of a Potent and Selective Novel Nonsteroidal Progesterone Receptor Agonist Tanaproget

(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A Wingless β-Catenin Agonist That Increases Bone Formation Rate

Discovery of Phenyl Acetic Acid Substituted Quinolines as Novel Liver X Receptor Agonists for the Treatment of Atherosclerosis

Pyrrole[2,3- d]azepino compounds as agonists of the farnesoid X receptor (FXR)

SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[ d][1,3]oxazin-2-ones as progesterone receptor antagonists

Novel 6-aryl-1,4-dihydrobenzo[ d] [1,3]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists

PTP1B Inhibition and Antihyperglycemic Activity in the ob/ob Mouse Model of Novel 11-Arylbenzo[b]naphtho[2,3-d]furans and 11-Arylbenzo[b]naphtho[2,3-d]thiophenes

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